Gliadin Does Not Induce Mucosal Inflammation or Basophil Activation in Patients With Nonceliac Gluten Sensitivity

Bucci, Cristina; Zingone, Fabiana; Russo, Ilaria; Morra, Ivonne; Tortora, Raffaella; Pogna, N. E.; Scalia, Giulia; Iovino, Paola; Ciacci, Carolina

doi:10.1016/j.cgh.2013.04.022

Cited by 67 publications

(46 citation statements)

References 21 publications

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“…Our results showed that the new BAT CD63-based detection on whole blood samples is not useful in FH and NCWS diag nosis. Furthermore, data from Ciacci et al do not confi rm the usefulness of BAT in NCWS diagnosis ( 39 ).…”

Section: The Usefulness Of Basophil Activation Assay In Ncws Diagnosismentioning

confidence: 98%

Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review

Carroccio

Mansueto

D’Alcamo

et al. 2013

American Journal of Gastroenterology

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OBJECTIVES:Non-celiac wheat sensitivity (NCWS) is a newly described clinical entity characterized by symptoms, which can involve the gastrointestinal tract, the nervous system, the skin, and other organs. There is little data on the pathogenesis of NCWS and it is probable that different pathogenic mechanisms are involved in the different clinical manifestations of the disease. The only common denominator of NCWS " syndrome " is wheat consumption: the symptoms disappear on exclusion of wheat from the diet, and reappear on wheat consumption. The objective of this study was to review our prior data regarding NCWS and to review relevant medical literature regarding NCWS, with particular attention to the hypothesis that NCWS patients could suffer from non-immunoglobulin E (IgE)-mediated wheat allergy. METHODS:We reviewed our data on 276 patients diagnosed with NCWS by means of double-blind placebocontrolled (DBPC) wheat challenge. The data indicating a possible wheat allergy diagnosis were examined and other data in the literature were reviewed; we review the role of serum immunoglobulin G antibodies and the basophil activation assay in food allergy, and the histology fi ndings in the food allergy diagnosis. RESULTS:The comparison between patients suffering from NCWS and presenting with irritable bowel syndrome (IBS) and controls with IBS not due to NCWS showed that NCWS was characterized by: a personal history of food allergy in the pediatric age (0.01), coexistent atopic diseases (0.0001), positive serum anti-gliadin (0.0001) and anti-betalactoglobulin (0.001) antibodies, positive cytofl uorimetric assay revealing in vitro basophil activation by food antigens (0.0001), and a presence of eosinophils in the intestinal mucosa biopsies (0.0001).CONCLUSIONS: Patients with NCWS and multiple food sensitivity show several clinical, laboratory, and histological characteristics that suggest they might be suffering from non-IgE-mediated food allergy. However, other pathogenic mechanisms need to be considered.

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Section: The Usefulness Of Basophil Activation Assay In Ncws Diagnosismentioning

confidence: 98%

Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review

Carroccio

Mansueto

D’Alcamo

et al. 2013

American Journal of Gastroenterology

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“…Moreover, the trigger/s of mucosal events leading to NCGS may not be necessarily represented by the same array of gluten peptides responsible for the CD development. In NCGS patients, gliadin fractions do not provoke a clear picture of inflammation upon contact with the duodenal mucosa or with peripheral basophils [20]. In vitro studies suggest that wheat ATIs could play a major role as triggers of the innate immune response in GS [21].…”

Section: Pathogenesismentioning

confidence: 99%

Gluten Sensitivity in Pediatrics: A Clinical Conundrum

et al. 2014

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“…Nevertheless, translation into human studies has shown varying pathology, immunology and conflicting mucosal immunological events. [27][28][29][30] Interpreting and drawing definitive conclusions from the few clinical trials that focus on NCGS is difficult because of weaknesses in the study design or execution, for example inconsistent definition of NCGS and inclusion criteria, small number of participants, inclusion of participants with elevated markers of coeliac disease (intraepithelial lymphocytosis in the duodenum and evidence of immunological activation), or the non-distinction between gluten and other wheat components.…”

Section: The Current Evidence For Ncgsmentioning

confidence: 99%

Non‐coeliac gluten sensitivity: piecing the puzzle together

Biesiekierski

Iven

2015

UEG Journal

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The avoidance of wheat-and gluten-containing products is a worldwide phenomenon. While coeliac disease is wellestablished, much remains unknown about whether gluten can be a trigger of gastrointestinal and/or extra-intestinal symptoms in patients without coeliac disease. In this article, we discuss the latest scientific evidence and our current understanding for the possible mechanisms of this largely ambiguous group, termed 'non-coeliac gluten sensitive' (NCGS). We can conclude that NCGS should be regarded as an independent disease outside of coeliac disease and wheat allergy, and that the number of patients affected is likely to be limited. Many questions remain unanswered and it needs to be verified whether the elimination of dietary gluten alone is sufficient for the control of symptoms, and to understand the overlap with other components of wheat.

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Gliadin Does Not Induce Mucosal Inflammation or Basophil Activation in Patients With Nonceliac Gluten Sensitivity

Cited by 67 publications

References 21 publications

Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review

Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review

Gluten Sensitivity in Pediatrics: A Clinical Conundrum

Non‐coeliac gluten sensitivity: piecing the puzzle together

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