The EKZ/AMC childhood cancer survivor cohort: methodology, clinical characteristics, and data availability

Sieswerda, Elske; Mulder, Renée L.; Dijk, Irma W.E.M. van; Dalen, Elvira C. van; Knijnenburg, Sebastiaan L.; Pal, Helena J.H. van der; Mud, Minke S.; Heinen, Richard C.; Caron, Huib N.; Kremer, Leontien C. M.

doi:10.1007/s11764-013-0283-9

Cited by 21 publications

(15 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Emma Children’s Hospital/Academic Medical Center (EKZ/AMC) childhood cancer survivor cohort is a single-center cohort study of CCS who survived at least five years since primary cancer diagnosis. Details of this study have been described previously [ 7 , 29 ]. Eligibility criteria were a primary childhood cancer diagnosis between 1966 and 1999 before age 18, survival at least five years since diagnosis and being alive at Jan 1 st 1995 (N = 1564).…”

Section: Methodsmentioning

confidence: 99%

High Hospitalization Rates in Survivors of Childhood Cancer: A Longitudinal Follow-Up Study Using Medical Record Linkage

et al. 2016

View full text Add to dashboard Cite

Hospitalization rates over time of childhood cancer survivors (CCS) provide insight into the burden of unfavorable health conditions on CCS and health care resources. The objective of our study was to examine trends in hospitalizations of CCS and risk factors in comparison with the general population. We performed a medical record linkage study of a cohort of 1564 ≥five-year CCS with national registers. We obtained a random sample of the general population matched on year of birth, gender and calendar year per CCS retrieved. We quantified and compared hospitalization rates of CCS and reference persons from 1995 until 2005, and we analyzed risk factors for hospitalization within the CCS cohort with multivariable Poisson models. We retrieved hospitalization information from 1382 CCS and 25583 reference persons. The overall relative hospitalization rate (RHR) was 2.2 (95%CI:1.9–2.5) for CCS compared to reference persons. CCS with central nervous system and solid tumors had highest RHRs. Hospitalization rates in CCS were increased compared to reference persons up to at least 30 years after primary diagnosis, with highest rates 5–10 and 20–30 years after primary cancer. RHRs were highest for hospitalizations due to neoplasms (10.7; 95%CI:7.1–16.3) and endocrine/nutritional/metabolic disorders (7.3; 95%CI:4.6–11.7). Female gender (P<0.001), radiotherapy to head and/or neck (P<0.001) or thorax and/or abdomen (P = 0.03) and surgery (P = 0.01) were associated with higher hospitalization rates in CCS. In conclusion, CCS have increased hospitalization rates compared to the general population, up to at least 30 years after primary cancer treatment. These findings imply a high and long-term burden of unfavorable health conditions after childhood cancer on survivors and health care resources.

show abstract

Section: Methodsmentioning

confidence: 99%

High Hospitalization Rates in Survivors of Childhood Cancer: A Longitudinal Follow-Up Study Using Medical Record Linkage

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In total, 1362 of 2596 patients survived their primary malignancy for 5 years or more. This cohort has been described previously …”

Section: Methodsmentioning

confidence: 99%

Changes in body mass index in long‐term childhood cancer survivors

Santen

Geskus

Raemaekers

et al. 2015

Cancer

View full text Add to dashboard Cite

BACKGROUND Previous studies have reported changes in the body mass index (BMI) with time in childhood cancer survivors (CCSs) during follow‐up. The limitations of these studies include that they described only a subgroup of survivors or used questionnaires with self‐reported heights and weights. The goal of this study was to examine BMI in a large cohort of long‐term CCSs and relate this to the BMI at diagnosis, age, sex, tumor type, treatment, and endocrine defects. METHODS All patients treated for childhood cancer at the Emma Children's Hospital/Academic Medical Center between 1966 and 1996 who had survived for at least 5 years were eligible for inclusion. For 893 CCSs with a mean follow‐up of 14.9 years, the BMI at the late effects outpatient clinic was compared with the BMI for the general Dutch population. RESULTS For girls, an increased prevalence of obesity was found. Risk factors for developing a high BMI at follow‐up were a younger age and a high BMI at diagnosis and treatment with cranial radiotherapy. A significantly increased prevalence of severe underweight was found in all adult subgroups except for females aged 26 to 45 years. An association was found between a low BMI at diagnosis and a low BMI at follow‐up. No treatment‐related variables could be related to changes in BMI. CONCLUSIONS The BMI at diagnosis is one of the most important predictors for the BMI at follow‐up, and this suggests an important genetic or environmental cause. Adult CCSs are at high risk for developing severe underweight at follow‐up. Future studies should focus on the causes and clinical consequences of underweight. Cancer 2015;121:4197–4204. © 2015 American Cancer Society.

show abstract

“…The main purpose of the outpatient clinic is to actively screen for health problems in the population of CCSs using standardized evidence-based follow-up guidelines. [10,11,[14][15][16] Health problems are defined as total burden of adverse health outcomes (clinical and subclinical disorders), including possible events that sometimes may not be related to the childhood cancer or its treatment.…”

Section: Health Problemsmentioning

confidence: 99%

Neuroblastoma With Intraspinal Extension: Health Problems in Long‐Term Survivors

Kraal

Blom

Tytgat

et al. 2016

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

The EKZ/AMC childhood cancer survivor cohort: methodology, clinical characteristics, and data availability

Cited by 21 publications

References 48 publications

High Hospitalization Rates in Survivors of Childhood Cancer: A Longitudinal Follow-Up Study Using Medical Record Linkage

High Hospitalization Rates in Survivors of Childhood Cancer: A Longitudinal Follow-Up Study Using Medical Record Linkage

Changes in body mass index in long‐term childhood cancer survivors

Neuroblastoma With Intraspinal Extension: Health Problems in Long‐Term Survivors

Contact Info

Product

Resources

About