General movements and magnetic resonance imaging in the prediction of neuromotor outcome in children born extremely preterm

Skiöld, Béatrice; Eriksson, Christina; Eliasson, Ann‐Christin; Ådén, Ulrika; Vollmer, Brigitte

doi:10.1016/j.earlhumdev.2013.03.014

Cited by 57 publications

(50 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…41,42 A combination of TEA MR imaging findings and 3-month CA general movement assessment demonstrates improved predictive validity over TEA MR imaging alone, [43][44][45] so evaluation of the relationships between this early MR imaging scoring system and concurrent clinical measures and the combination of early MR imaging and clinical measures to predict later outcomes is warranted.…”

Section: Discussionmentioning

confidence: 99%

Validation of an MRI Brain Injury and Growth Scoring System in Very Preterm Infants Scanned at 29- to 35-Week Postmenstrual Age

George¹,

Fiori

Fripp

et al. 2017

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Validation of an MRI Brain Injury and Growth Scoring System in Very Preterm Infants Scanned at 29- to 35-Week Postmenstrual Age

George¹,

Fiori

Fripp

et al. 2017

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…28 Others have revealed that MRI may provide additive information to predict neuromotor outcomes, 29 complementary to specific findings such as periventricular echodensities by CUS, 30 or neurologic examination. 31,32 Our results suggest that some type of near-term imaging (late CUS or brain MRI) adds value over perinatal/neonatal factors and early CUS alone. Predictive capability as measured by AUC of the ROC was best in models with all neuroimaging, but improvement with the addition of MRI was marginal.…”

Section: Discussionmentioning

confidence: 85%

Neuroimaging and Neurodevelopmental Outcome in Extremely Preterm Infants

et al. 2015

View full text Add to dashboard Cite

BACKGROUND: Extremely preterm infants are at risk for neurodevelopmental impairment (NDI). Early cranial ultrasound (CUS) is usual practice, but near-term brain MRI has been reported to better predict outcomes. We prospectively evaluated MRI white matter abnormality (WMA) and cerebellar lesions, and serial CUS adverse findings as predictors of outcomes at 18 to 22 months' corrected age.METHODS: Early and late CUS, and brain MRI were read by masked central readers, in a large cohort (n = 480) of infants ,28 weeks' gestation surviving to near term in the Neonatal Research Network. Outcomes included NDI or death after neuroimaging, and significant gross motor impairment or death, with NDI defined as cognitive composite score ,70, significant gross motor impairment, and severe hearing or visual impairment. Multivariable models evaluated the relative predictive value of neuroimaging while controlling for other factors.RESULTS: Of 480 infants, 15 died and 20 were lost. Increasing severity of WMA and significant cerebellar lesions on MRI were associated with adverse outcomes. Cerebellar lesions were rarely identified by CUS. In full multivariable models, both late CUS and MRI, but not early CUS, remained independently associated with NDI or death (MRI cerebellar lesions: odds ratio, 3.0 [95% confidence interval: 1.3-6.8]; late CUS: odds ratio, 9.8 [95% confidence interval: 2.8-35]), and significant gross motor impairment or death. In models that did not include late CUS, MRI moderate-severe WMA was independently associated with adverse outcomes.CONCLUSIONS: Both late CUS and near-term MRI abnormalities were associated with outcomes, independent of early CUS and other factors, underscoring the relative prognostic value of near-term neuroimaging.WHAT'S KNOWN ON THIS SUBJECT: White matter abnormality (WMA) on neuroimaging is considered a crucial link with adverse neurodevelopmental outcome in preterm infants. Brain MRI is more sensitive in detecting WMA than cranial ultrasound (CUS), but questions remain about timing and prognostic value of modalities.WHAT THIS STUDY ADDS: Near-term CUS and MRI abnormalities were associated with adverse 18-to 22-month outcomes, independent of early CUS and other factors, underscoring the relative prognostic value of later neuroimaging in this large, extremely preterm cohort surviving to near-term. Trained research staff at each center collected maternal, demographic, perinatal, and neonatal data by using common definitions that were developed by NICHD NRN investigators and described in previous publications. [13][14][15][16] Data were transmitted to the NRN Data Coordinating Center at RTI International, which stored, managed, and analyzed all data. Neuroimaging: CUS and Brain MRI Cranial UltrasoundAn "early" CUS at 4 to 14 days, and a "late" CUS at 35 to 42 weeks' postmenstrual age (PMA) were obtained for NEURO study participants. CUS imaging was per local center clinical protocol. Mastoid, posterior fossa, or cine views were not specifically required. Central reader interpretat...

show abstract

“…Prognostic models based on gestational age, neonatal morbidities and therapeutic interventions like the use of steroids in the neonatal period (4), as well as neurological assessment tools (5,6), magnetic resonance imaging (MRI) (7) or a combination of these (8,9), may be used to predict outcomes in high-risk infants. A common finding is that accuracy of neurologic assessment increases with age on assessment, delaying interventions beyond the time when brain plasticity is assumed to be at its highest (10,11).…”

Section: Introductionmentioning

confidence: 99%

Computer-based video analysis identifies infants with absence of fidgety movements

et al. 2017

View full text Add to dashboard Cite

show abstract

General movements and magnetic resonance imaging in the prediction of neuromotor outcome in children born extremely preterm

Cited by 57 publications

References 28 publications

Validation of an MRI Brain Injury and Growth Scoring System in Very Preterm Infants Scanned at 29- to 35-Week Postmenstrual Age

Validation of an MRI Brain Injury and Growth Scoring System in Very Preterm Infants Scanned at 29- to 35-Week Postmenstrual Age

Neuroimaging and Neurodevelopmental Outcome in Extremely Preterm Infants

Computer-based video analysis identifies infants with absence of fidgety movements

Contact Info

Product

Resources

About