Correlation Between Serum Magnesium Levels and Hepatic Encephalopathy in Immediate Post Liver Transplantation Period

Lopes, Paula Juliano; Mei, M.F.T.; Guardia, A.C.; Stucchi, R.S.B.; Udo, E.Y.; Warwar, Maria Isabel; Boin, I.F.S.F.

doi:10.1016/j.transproceed.2013.02.011

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…Association of post‐LT hypomagnesemia and development of NE remains controversial. Some studies identified it as a risk factor for NE, especially seizures , whereas other series found no association . In this cohort, low magnesium levels were an independent variable for NE development and were more specifically related to visual disturbances or slurred speech.…”

Section: Discussionmentioning

confidence: 49%

Neurological events after liver transplantation: a single-center experience

et al. 2014

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SummaryThe aim of this study was to identify potential risk factors linked to neurologic events (NE) occurring after liver transplantation (LT) and use them to construct a model to predict such events. From odds ratios (OR) of risk factors, a scoring system was assessed using multivariate regression analysis. Forty-one of 307 LT patients presented NE (13.3%), with prolonged hospital stay and decreased post-LT survival. On multivariate analysis, factors associated with NE included: severe pre-LT ascites OR 3.9 (1.80-8.41; P = 0.001), delta sodium ≥12 mEq/l OR 3.5 (1.36-8.67; P = 0.01), and post-LT hypomagnesemia OR 2.9 (1.37-5.98; P = 0.005). Points were assigned depending on ORs as follows: ascites 4 points, and hypomagnesemia and delta sodium ≥12 mEq/l, 3 points each (score range = 0-10 points). ROC curve analysis suggested good discriminative power for the model, with a c-statistic of 0.72 (CI 0.62-0.81; P < 0.0001), best performance for a cutoff value >3 points (71% sensitivity, 60% specificity). NE risk increased progressively from 6.4%, to 10.3%, 12.8%, 31.5% and 71.0% as scores rose from 0 to 3, 4, 6-7 and 10 cumulative points, respectively. The score described helps to identify patients potentially at risk for neurologic events, and its prevention would decrease morbidity and mortality after LT.

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Section: Discussionmentioning

confidence: 49%

Neurological events after liver transplantation: a single-center experience

et al. 2014

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“…Raj et al (30) observed that 59.3% of patients who had undergone liver transplantation showed Mg deficiency for at least 20 days after surgery. Lopes et al (21) evaluated 83 patients who underwent liver transplantation and the Mg level in patients without encephalopathy was 1.6±0.3 mEq/L. In this study it was observed that 100% of patients on a liver transplant waiting list had Mg deficiency with a mean of 0.9±0.2 mg/dL, which may be associated with alterations in intestinal absorption and/or increased renal excretion.…”

Section: Discussionmentioning

confidence: 83%