Conventional and Advanced MRI Features of Pediatric Intracranial Tumors: Posterior Fossa and Suprasellar Tumors

Plaza, Michael J.; Borja, Maria J.; Altman, Nolan; Saigal, Gaurav

doi:10.2214/ajr.12.9725

Cited by 83 publications

(74 citation statements)

References 43 publications

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“…Beside the initial diagnosis, other goals of brain MRI for pediatric brain tumors should include differentiation of specific tumor types, grading tumors, distinguishing viable tumor from necrotic tissue, guiding stereotactic biopsy, and determining treatment responses (23). As conventional anatomic brain MRI is often limited in achieving these goals, advanced MRI techniques, such as diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), functional MRI, perfusion imaging, MR spectroscopy (MRS), and susceptibility-weighted imaging (SWI), are commonly included in the MRI protocol (23456789). The recently introduced chemical exchange saturation transfer (CEST) imaging is at the early stage of clinical investigations (10).…”

Section: Introductionmentioning

confidence: 99%

Advanced MRI for Pediatric Brain Tumors with Emphasis on Clinical Benefits

Goo

2017

Korean J Radiol

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Conventional anatomic brain MRI is often limited in evaluating pediatric brain tumors, the most common solid tumors and a leading cause of death in children. Advanced brain MRI techniques have great potential to improve diagnostic performance in children with brain tumors and overcome diagnostic pitfalls resulting from diverse tumor pathologies as well as nonspecific or overlapped imaging findings. Advanced MRI techniques used for evaluating pediatric brain tumors include diffusion-weighted imaging, diffusion tensor imaging, functional MRI, perfusion imaging, spectroscopy, susceptibility-weighted imaging, and chemical exchange saturation transfer imaging. Because pediatric brain tumors differ from adult counterparts in various aspects, MRI protocols should be designed to achieve maximal clinical benefits in pediatric brain tumors. In this study, we review advanced MRI techniques and interpretation algorithms for pediatric brain tumors.

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Section: Introductionmentioning

confidence: 99%

Advanced MRI for Pediatric Brain Tumors with Emphasis on Clinical Benefits

Goo

2017

Korean J Radiol

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“…On T2WI, tubular flow voids can be found since they have large feeding and draining vessels in the periphery and within the solid component (10). This feature is not present in our case and hemangioblastomas are extremely rare in children younger than 18 years old with an incidence of less than 1 per one million, so the possibility of hemangioblastoma is low.…”

Section: Jksronlineorgmentioning

confidence: 48%

Cerebellar Clear Cell Ependymoma in a 10-Year-Old Girl

Thinzar

Park

Moon

et al. 2016

J Korean Soc Radiol

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“…Head CT is used to determine whether there is an initial intracranial space and MRI shows the characteristics and properties of a glioma better than CT. Consequently, MRI has become the preferred method for evaluating gliomas. However, preoperative grading of a glioma often relies only on conventional MRI, which is frequently insufficient [26]. The degree of malignancy of a tumor is closely related to the microvessel structure and tumor cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, their use is limited in patients with severe renal insufficiency or allergies to contrast medium, and in those who cannot co-operate with the examination. High-pressure syringes and contrast medium are expensive and repeated examinations can be an economic burden for patients [29]. …”

Section: Discussionmentioning

confidence: 99%

Clinical utility of arterial spin labeling for preoperative grading of glioma

Wang

et al. 2018

Bioscience Reports

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There were obvious differences in biological behavior and prognosis between low- and high-grade gliomas, it is of great importance for clinicians to make a right judgement for preoperative grading. We conducted a comprehensive meta-analysis to evaluate the clinical utility of arterial spin labeling for preoperative grading. We searched the PubMed, Embase, China National Knowledge Infrastructure, and Weipu electronic databases for articles published through 10 November 2017 and used ‘arterial spin-labeling’ or ‘ASL perfusion, grading’ or ‘differentiation, glioma’ or ‘glial tumor, diagnostic test’ as the search terms. A manual search of relevant original and review articles was performed to identify additional studies. The meta-analysis included nine studies. No obvious heterogeneity was found in the data in a fixed-effect model. The pooled sensitivity and specificity were 90% (95% confidence interval (CI): 0.84–0.94) and 91% (95% CI: 0.83–0.96), respectively, and the pooled positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 10.40 (95% CI: 2.21–20.77) and 0.11 (95% CI: 0.07–0.18). The diagnostic odds ratio (DOR) was 92.47 (95% CI: 39.61–215.92). The diagnostic score was 4.53 (95% CI: 3.68–5.38). The area under the curve (AUC) was 0.94 (95% CI: 0.91–0.96). Subgroup analyses did not change the pooled results. No publication bias was found (P=0.102). The normalized maximal tumor blood flow/normal white matter ratio obtained with the arterial spin labeling technique was relatively accurate for distinguishing high/low-grade glioma. As a non-invasive procedure with favorable repeatability, this index may be useful for clinical diagnostics.

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Conventional and Advanced MRI Features of Pediatric Intracranial Tumors: Posterior Fossa and Suprasellar Tumors

Cited by 83 publications

References 43 publications

Advanced MRI for Pediatric Brain Tumors with Emphasis on Clinical Benefits

Advanced MRI for Pediatric Brain Tumors with Emphasis on Clinical Benefits

Cerebellar Clear Cell Ependymoma in a 10-Year-Old Girl

Clinical utility of arterial spin labeling for preoperative grading of glioma

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