Bridging the gap between basic and applied biology: towards preclinical translation

Cagan, Ross; Justice, Monica J.; Tidmarsh, George F.

doi:10.1242/dmm.012450

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…More importantly, we were able to measure these similarities and differences. The gap between basic science and medicine vocabulary has already been identified by several authors ( 5 - 7 ). We quantified this gap and showed that not only was it huge by 1975, but the gap had widened over the last 50 years.…”

Section: Discussionmentioning

confidence: 99%

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Do medicine and cell biology talk to each other? A study of vocabulary similarities between fields

Azevedo

Seixas

Jurberg

et al. 2021

Braz J Med Biol Res

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A close interaction between basic science and applied medicine is to be expected. Therefore, it is important to measure how far apart the field of cell biology and medicine are. Our approach to estimating the distance between these fields was to compare their vocabularies and to quantify the difference in word repertoire. We compared the vocabulary of the title and abstract of articles available in PubMed in two selected high-impact journals in each field: cell biology, medicine, and translational science.Although each journal has its own editorial policy, we showed that within each field there is a small vocabulary difference between the two journals. We developed a word similarity index that can measure how much journals share a common vocabulary. We found a high similarity index between each cell biology (91%), medical (71-74%), and translational journal (65%). In contrast, the comparison between medicine and biology journals produced low correlation values (22-36%), suggesting that their vocabularies are quite dissimilar. Translational medicine journals had medium similarity values when compared to cell biology journals (52-70%) and medicine journals (27-59%). This approach was also performed in 10-year periods to evaluate the evolution of each field. Using the ''onomics'' strategy presented here, we observed that differences in vocabulary of basic science and medicine have been increasing over time. Since translational medicine has an intermediate vocabulary, we confirmed that translational medicine is an efficient approach to bridge this gap.

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Section: Discussionmentioning

confidence: 99%

“…It is therefore plausible to expect that the more these two fields exchange information, the greater the benefits for both sides will be. Although this interaction should be intimate, a great divergence has developed between them over the years, and attempts to resolve this have led to the emergence of translational medicine (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Do medicine and cell biology talk to each other? A study of vocabulary similarities between fields

Azevedo

Seixas

Jurberg

et al. 2021

Braz J Med Biol Res

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“…Ross, Monica and George are just the right team to guide the next phase of the journal’s growth. They describe their vision for the journal – a vision that I fully support – in their introductory Editorial (Cagan et al, 2013). …”

Section: Launching Dmm and Letting It Gomentioning

confidence: 99%

Provoking progress: a new chapter

Siegel

2013

Disease Models &Amp; Mechanisms

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SummaryJournals do more than publish collections of research articles and reviews; they also create community, influence standards for community behavior and ‘provoke progress’ in a particular field. In this Editorial, founding Editor-in-Chief Vivian Siegel compares launching a journal to raising a child, and reflects on the choices and successes of her tenure at DMM as she passes the leadership of the journal to new editors.

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“…The academic editors of DMM, currently led by Editor-in-Chief Monica Justice and Senior Editor Ross Cagan, work closely with the editorial team in Cambridge, UK, to ensure that DMM serves its community of readers, authors and reviewers as effectively as possible within this ecosystem (Cagan et al, 2013). …”

mentioning

confidence: 99%