Brachytherapy versus radical hysterectomy after external beam chemoradiation with gemcitabine plus cisplatin: a randomized, phase III study in IB2–IIB cervical cancer patients

Abstract

This study failed to demonstrate that RH after EBRT-CT is superior to standard BCT.

Clinical trials in low and middle-income countries — Successes and challenges

“…Radical hysterectomy may be considered after RT or chemoradiation to a dose of 50 Gy. This recommendation was based on the result of a randomized clinical trial conducted in Mexico (Cetina et al, 2013). The survival and progression-free survival of patients with stage IB2 to IIB disease were equivalent between traditional chemoradiation therapy and chemoradiation to 50 Gy followed by radical hysterectomy.…”

Clinical outcome of recurrent locally advanced cervical cancer (LACC) submitted to primary multimodality therapies

“…In this context, investigational approaches employing completion surgery after CTRT have been explored in order to allow, with respect to brachytherapy, the evaluation of pathologic response and the surgical removal of possible radiochemoresistant tumor foci thus improving local control and potentially survival. This trimodality approach indeed, resulted in disease-free and overall survival rates at least comparable to exclusive chemoradiation, with a different long-term toxicity profile [3][4][5]: in particular, chronic toxic effects (e.g. proctitis, cystitis, hydronephrosis) resulted lower compared to exclusive CTRT probably because of replacement of utero-vaginal brachytherapy with completion surgery [4].…”

“…proctitis, cystitis, hydronephrosis) resulted lower compared to exclusive CTRT probably because of replacement of utero-vaginal brachytherapy with completion surgery [4]. Among major criticisms raised against CTRT followed by radical surgery are the potential higher risk of long-term complications together with the potential depletion of all available treatment modalities for the recurrent disease [4][5][6]. Indeed, the treatment choice for recurrent disease is primarily dependent on previous therapy and secondarily on the site of the recurrent tumor together with the patient's performance status [7,8].…”

Patterns of cervical cancer care in Argentina: Applying ASCO recommendations adjusted by local resources

“…If residual disease persists 2 months after radiotherapy, extrafascial hysterectomy can be a valid option. (Chuang et al, 2016, Nagase et al, 2010, Cetina et al, 2013, Kokka et al, 2015, Censo Nacional de Población, 2010). …”