Hypolipidemic Activity of Okra is Mediated Through Inhibition of Lipogenesis and Upregulation of Cholesterol Degradation

Wang, Hong; Li, Zhuoshi; Ren, Dandan; Yang, Shang‐Tian

doi:10.1002/ptr.4998

Cited by 29 publications

(17 citation statements)

References 35 publications

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“…Our findings stand in line with results obtained by Wang et al, who demonstrated that okra intake decreased serum and hepatic total cholesterol and triglyceride levels, and enhanced fecal excretion of bile acids in mice [46]. In other study, Kahlon et al showed that okra polysaccharides have strong bile acid binding properties [47].…”

Section: Discussionsupporting

confidence: 92%

Double-Blind, Randomized, Three-Armed, Placebo-Controlled, Clinical Investigation to Evaluate the Benefit and Tolerability of Two Dosages of IQP-AE-103 in Reducing Body Weight in Overweight and Moderately Obese Subjects

et al. 2019

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Objective. This study was performed to determine the efficacy and tolerability/safety of IQP-AE-103 on body weight reduction in overweight to moderately obese adults. Methods. A double-blind, randomized, placebo-controlled trial involved one hundred and eight subjects (BMI between 25 and 35 kg/m2) that were randomly assigned to either the low-dose or the high-dose IQP-AE-103 group, or the placebo group. Following a 2-week run-in period, subjects received two capsules of investigational product after three daily main meals for 12 weeks. Subjects were instructed to maintain a nutritionally balanced hypocaloric diet according to the individual’s energy requirement. Body weight, body fat, and waist and hip circumference were measured at baseline, and after 2, 4, 8, and 12 weeks. Subjects also rated their feelings of hunger and fullness using visual analogue scales, and food craving on a 5-point scale at the same time intervals. Blood samplings for safety laboratory parameters were taken before and at the end of the study. Results. After 12 weeks of intake, the high-dose IQP-AE-103 group had a significantly greater weight loss compared with the placebo (5.03 ± 2.50 kg vs. 0.98 ± 2.06 kg, respectively; p<0.001) and the low-dose group (3.01 ± 2.19 kg; p=0.001). The high-dose group experienced a decrease in body fat of 3.15 ± 2.41 kg compared with a decrease of 0.23 ± 2.74 kg for the placebo group (p<0.001). High-dose IQP-AE-103 also decreased the feeling of hunger in 66% subjects. A beneficial effect of IQP-AE-103 on the lipid metabolism was also demonstrated in the subgroup of subjects with baseline total cholesterol levels above 6.2 mmol/L. No side effects related to the intake of IQP-AE-103 were reported. Conclusions. These findings indicate that IQP-AE-103 could be an effective and safe weight loss intervention. This trial is registered with NCT03058367.

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Section: Discussionsupporting

confidence: 92%

Double-Blind, Randomized, Three-Armed, Placebo-Controlled, Clinical Investigation to Evaluate the Benefit and Tolerability of Two Dosages of IQP-AE-103 in Reducing Body Weight in Overweight and Moderately Obese Subjects

et al. 2019

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“…Moreover, okra upregulated cholesterol degradation through CYP7A1. The high amounts of okra fibers are able to bind to bile acids which led to decrease TC through interfering with bile acids reabsorption (H. Wang, Chen, Ren, & Yang, 2014). Furthermore, in the model of induction of hyperlipidemia through intake of sucrose-rich diet, the hydroalcoholic extract of okra (400 mg/kg) reduced TAG more than nicotinic acid (González Madariaga, Castillo Alfonso, Santiesteban Muñoz, Mena Linares, & Blanco Machado, 2015).…”

Section: Effect Of Okra On Dyslipidemiamentioning

confidence: 99%

Effect of Abelmoschus esculentus (okra) on metabolic syndrome: A review

Esmaeilzadeh

Razavi

Hosseinzadeh

2020

Phytotherapy Research

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Metabolic syndrome is a disorder characterized by dyslipidemia, insulin resistance, abdominal fat, high blood pressure, hypertriglyceridemia, and diminished high density lipoprotein cholesterol. Okra (Abelmoschus esculentus L.), routinely called lady's finger, has belonged to the Malvaceae family. Okra is considered as a valuable crop due to the multiple functions of its leaves, buds, flowers, pods, stems, and seeds in traditional and modern medicines. Several bioactive components are presented in different parts of okra including polyphenolic compounds especially oligomeric catechins and flavonol derivatives such as quercetin. The antioxidant, anti‐inflammatory, anticancer, immunomodulatory, gastroprotective, neuroprotective, lipid lowering, and antidiabetic effects of okra have been established. Although different in vivo and in vitro studies revealed that okra has an ability to overcome metabolic syndrome symptoms, the lack of clinical studies is notable. So, further clinical trials should be accomplished to confirm the role of okra in metabolic syndrome. The aims of this review are to gather different studies regarding the potential efficacy of okra in metabolic syndrome.

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“…Mice liver total RNA was extracted using the RNeasy mini kit Primers for mouse LDLR were F: 5'-GCG TAT CTG TGG CTG ACA CC-3' and R: 5'-TGT CCA CAC CAT TCA AAC CC-3', mouse SREBF2 were F: 5'-GGC CTC TCC TTT AAC CCC TT-3' and R: 5'-CAC CAT TTA CCA GCC ACA GG-3', mouse HMGCR were F: 5'-GTG GCA GAA AGA GGG AAA GG-3' and R: 5'-CGC CTT TGT TTT CTG GTT GA-3' [2], and mouse β-actin were F: 5'-TGT CCA CCT TCC AGC AGA TGT-3' and R: 5'-AGC TCA GTA ACA GTC CGC CTA GA-3' [50]. Relative gene expression levels were calculated as previously described [37] using β-actin gene as the internal control and were expressed as the fold-change relative to the HCD-control group.…”

Section: Expression Analysis Of Cholesterol Metabolism-related Genes mentioning

confidence: 99%

Functional Probiotic Characterization and In Vivo Cholesterol-Lowering Activity of Lactobacillus helveticus Isolated from Fermented Cow Milk

Damodharan¹,

Palaniyandi²,

Yang³

et al. 2016

Journal of Microbiology and Biotechnology

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We characterized the probiotic properties of strains KII13 and KHI1 isolated from fermented cow milk by in vitro and in vivo studies. The strains exhibited tolerance to simulated orogastrointestinal condition, adherence to Caco-2 cells, and antimicrobial activity. Both strains produced bioactive tripeptides, isoleucylprolyl-proline and valyl-prolyl-proline, during fermentation of milk. KII13 showed higher in vitro cholesterol-lowering activity (47%) compared with KHI1 (28%) and ATCC 15009 (22%), and hence, it was selected for in vivo study of cholesterol-lowering activity in atherogenic diet-fed hypercholesterolemic mice. For the study, mice were divided into four groups (., normal diet control group, atherogenic diet control group (HCD), KII13- atherogenic diet group (HCD-KII13), and ATCC 43121-atherogenic diet group (HCD-) as positive control). The serum total cholesterol level was significantly decreased by 8.6% and 7.78% in the HCD-KII13 and HCD- groups ( < 0.05), respectively, compared with the HCD group. Low-density lipoprotein cholesterol levels in both HCD-KII13 and HCD- groups were decreased by 13% and 11%, respectively, compared with the HCD group (both, < 0.05). Analysis of cholesterol metabolism-related gene expression in mice liver showed increased expression of and genes in mice fed with KII13. By comparing all the results, we conclude that KII13 could be used as a potential probiotic strain to produce antihypertensive peptides and reduce serum cholesterol.

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Hypolipidemic Activity of Okra is Mediated Through Inhibition of Lipogenesis and Upregulation of Cholesterol Degradation

Cited by 29 publications

References 35 publications

Double-Blind, Randomized, Three-Armed, Placebo-Controlled, Clinical Investigation to Evaluate the Benefit and Tolerability of Two Dosages of IQP-AE-103 in Reducing Body Weight in Overweight and Moderately Obese Subjects

Double-Blind, Randomized, Three-Armed, Placebo-Controlled, Clinical Investigation to Evaluate the Benefit and Tolerability of Two Dosages of IQP-AE-103 in Reducing Body Weight in Overweight and Moderately Obese Subjects

Effect of Abelmoschus esculentus (okra) on metabolic syndrome: A review

Functional Probiotic Characterization and In Vivo Cholesterol-Lowering Activity of Lactobacillus helveticus Isolated from Fermented Cow Milk

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