Lipid-Associated Rheumatologic Syndromes

Kedar, Eyal; Gardner, Gregory

doi:10.1016/j.rdc.2013.02.014

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…Richette and Bardin (2010) identified five clusters of gouty comorbidity by using cluster analysis: low morbidity, obesity with a high prevalence of hypertension, a high prevalence of type 2 DM, cholesterol abnormality and CVD with chronic kidney failure and frequent use of diuretics . The possible explanation for the differences in results is that gout induces endothelial impairment and dysfunction of nitric oxide syntheses, causing abnormal lipid metabolism and vascular constriction, and further leading to atherosclerosis and hypertension . The comorbidities caused by vascular damage would formulate a comorbidity cluster of gout; therefore, adopting an appropriate strategy for the management and prevention of vascular disease in female and male populations with gout is of clinical relevance.…”

Section: Discussionmentioning

confidence: 99%

“…10 The possible explanation for the differences in results is that gout induces endothelial impairment and dysfunction of nitric oxide syntheses, causing abnormal lipid metabolism and vascular constriction, and further leading to atherosclerosis and hypertension. 27,28 The comorbidities caused by vascular damage would formulate a comorbidity cluster of gout; therefore, adopting an appropriate strategy for the management and prevention of vascular disease in female and male populations with gout is of clinical relevance.…”

Section: Discussionmentioning

confidence: 99%

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Differential risk group of developing stroke among older women with gouty arthritis: A latent transition analysis

Huang

Chiang

Hsu

et al. 2019

Eur J Clin Investigation

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Objective Gout‐related comorbidities are intricate and its clinical features may demonstrate sex difference; however, few studies have evaluated the links between comorbidities and gout in a female population. The objectives of this study were to compare the aggregation and transitive trajectories of comorbidities of gout, and their consequences in female and male gout populations. Methods A prospective cohort study was conducted using data from the Taiwan National Health Insurance Research Database. A female and male gout population were followed up from 2000 to 2009 to identify the comorbidities of cardiovascular disease, hyperlipidemia, hypertension, diabetes mellitus (DM) and chronic kidney disease. The cumulative incidence of stroke from 2000 to 2010 was examined. A latent trajectory analysis was used to determine the transitive trajectories of the comorbidities of gout. Results Both female and male patients with gout had five risk cluster transition (CT) phenotypes of comorbidities within 10‐year follow‐up: CT1 and CT2, with various persistent comorbidities; CT3, with few persistent comorbidities; and CT4 and CT5, with transfer to cluster 1 from other clusters. The female participants in CT2 predominantly experienced DM and were associated with significantly increased risk of developing stroke. Conclusion Diabetes is a notable risk factor for the development of stroke in female patients with gout. Early assessment and management for the comorbidities of gout, particularly in DM, would effectively reduce future stroke risk in female gout population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Differential risk group of developing stroke among older women with gouty arthritis: A latent transition analysis

Huang

Chiang

Hsu

et al. 2019

Eur J Clin Investigation

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“…In high-cholesterol environments, such as familial hyperlipidemia, lipids accumulate within the extracellular matrix of the tendon, which have been demonstrated to affect several tendon mechanical properties, including stiffness and modulus. 1,7,16,18 Mechanisms to explain these cholesterol-related changes are multiple and include alterations in tenocyte gene and protein expression, matrix turnover, tissue vascularity, and cytokine production. 5,25,27 Much of the pathophysiology of lipid-related tendon disorders remains incompletely understood.…”

Section: Discussionmentioning

confidence: 99%

“…In high-cholesterol environments, such as familial hyperlipidemia, lipids accumulate within the extracellular matrix of the tendon, which have been demonstrated to affect several tendon mechanical properties, including stiffness and modulus. 1,16,18 Hyperlipidemia has been clearly found to be an independent risk factor for the development of rotator cuff disease in recent studies. 2,21,28 Recent animal studies have also demonstrated that hyperlipidemia is associated with poor tendon-bone healing after rotator cuff repair; however, these findings have not been substantiated in human studies.…”

mentioning

confidence: 99%

Perioperative Serum Lipid Status and Statin Use Affect the Revision Surgery Rate After Arthroscopic Rotator Cuff Repair

et al. 2017

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The present study found a significant association between moderate and high perioperative total cholesterol and LDL levels and the rate of revision surgery after primary arthroscopic rotator cuff repair. Furthermore, the use of statin agents appeared to mitigate the need for revision rotator cuff repair. Further prospective studies are necessary to validate these preliminary findings and determine if better perioperative lipid control can improve clinical outcomes after arthroscopic rotator cuff repair.

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“…Sehr selten ist eine akut auftretende Arthritis im Bereich großer Gelenke in Assoziation mit flüssigen Lipidkristallen beschrieben, die spontan oder unter NSAR-Therapie innerhalb weniger Tage wieder verschwindet. Bei der mikroskopischen Untersuchung der Synovialflüssigkeit kommen die Lipideinlagerungen als positiv doppel brechende rundliche Gebilde mit Malteserkreuzartefakten zur Darstellung [57].…”

Section: Lipid-/cholesterin-arthropathieunclassified

Kristallarthropathien und andere Gelenkerkrankungen durch Ablagerungen

Frohne¹,

Dechant²,

Sander³

2020

Arthritis und Rheuma

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ZUSAMMENFASSUNGDurch Kristalle und andere Ablagerungen ausgelöste Arthropathien können sich als Zufallsbefund ohne Symptome, aber auch als akute immobilisierende Arthritis eines oder mehrerer Gelenke manifestieren. Sie treten auch koinzident mit anderen Arthropathien und Arthritiden auf. Typisch sind symptomfreie Intervalle. Aber auch chronisch progrediente Erkrankungsverläufe sind bekannt. Die häufigsten Erkrankungen sind durch CPP- und Urat-Kristalle ausgelöst, andere seltenere Ursachen sind die Hämochromatose, Oxalatarthropathie, Ochronose, Lipid- oder Amyloidoseablagerung. Die durch Ablagerungen ausgelösten Arthropathien können damit auch immer ein Indikator für eine Allgemeinerkrankung sein, welche dann einer ganzheitlichen internistischen Betrachtung bedarf. Die Erkrankungswahrscheinlichkeiten nehmen mit dem Alter zu. Neben der typischen Anamnese und Klinik sind die Bildgebung, hier vor allem Ultraschall und die Dual Energy Computertomografie (DECT), die Labordiagnostik inklusive der Synoviaanalyse essenzielle Bausteine der Diagnostik. Die Therapie ist im akuten Schub symptomatisch, sofern möglich sollte eine gezielte Prophylaxe weiterer Ablagerungen erfolgen.

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Lipid-Associated Rheumatologic Syndromes

Cited by 6 publications

References 45 publications

Differential risk group of developing stroke among older women with gouty arthritis: A latent transition analysis

Differential risk group of developing stroke among older women with gouty arthritis: A latent transition analysis

Perioperative Serum Lipid Status and Statin Use Affect the Revision Surgery Rate After Arthroscopic Rotator Cuff Repair

Kristallarthropathien und andere Gelenkerkrankungen durch Ablagerungen

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