Neural correlates of visual integration in Williams syndrome: Gamma oscillation patterns in a model of impaired coherence

Bernardino, Inês; Castelhano, João; Farivar, Reza; Silva, Eduardo D.

doi:10.1016/j.neuropsychologia.2013.03.020

Cited by 15 publications

(26 citation statements)

References 52 publications

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“…50 The documented dorsal stream vulnerability and impaired 3D visual integration in patients with WBS is associated with distinct neural correlates and cognitive strategies to reach visual coherence. 51,52 The information from facial features and finegrained details might be critical not only for accurate processing of facial expressions, 46 but also for the rapid detection of threat-related signals, such as fearful faces. 53,54 Deficient input from visual areas may also have contributed to the absence of an amygdala response to threat-related faces observed in our study.…”

Section: J Psychiatry Neurosci 2016;41(3)mentioning

confidence: 99%

Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study

Binelli

Muñiz

Subirà

et al. 2016

jpn

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Section: J Psychiatry Neurosci 2016;41(3)mentioning

confidence: 99%

Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study

Binelli

Muñiz

Subirà

et al. 2016

jpn

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“…We found that a distinct neural network is recruited in WS, namely, a parallel medial dorsal pathway, in response to the performance-matched 3-D SFM task as compared with the control group in the presence of a relatively lower degree of activation in the ventral stream regions. Under such conditions, we could establish the neural substrates of reorganization hypothesis that was suggested by our previous EEG study (Bernardino et al, 2013). Accordingly, WS participants showed very different lateral versus medial dorsal activation patterns as compared with controls.…”

Section: Discussionmentioning

confidence: 56%

“…The WS participants were identified from a large sample of participants who had previously participated in our studies (Bernardino et al, 2012(Bernardino et al, , 2013. The selection was based on the age (≥15 years) and on the ability to cooperate in the fMRI acquisition.…”

Section: Methods Participantsmentioning

confidence: 99%

“…Importantly, object and depth perception from motion cues was also reported as being affected in this condition (CasteloBranco et al, 2007;Mendes et al, 2005) with WS participants exhibiting impairments in 3-D SFM perception into a larger extent than those found in 2-D motion tasks (Mendes et al, 2005). The electrophysiological neural underpinnings of such impairments in 3-D coherent perception were investigated in a previous EEG study (Bernardino, Castelhano, Farivar, Silva, & Castelo-Branco, 2013), where we identified atypical neural responses to 3-D SFM conditions as revealed by distinct ERP waveform components. To investigate the cortical generators of these distinct neural responses, source localization analyses demonstrated more posterior (occipital) SFM-related sources in the WS group as compared with controls, who showed more parietal sources.…”

Section: Introductionmentioning

confidence: 90%

“…An experimental task using videos of SFM-defined faces and chairs with the duration of 980 msec (for further details, see Bernardino et al, 2013;Graewe, De Weerd, Farivar, & Castelo-Branco, 2012;Farivar, Blanke, & Chaudhuri, 2009) was conducted to localize the regions that responded to SFM stimulus in both groups Figure 1A. Face stimuli consisted of 3-D laser-scanned heads from the Max-Planck Face Database, and chair stimuli were selected from a chair model database.…”

Section: Sfm Feature Localizer Task: Stimuli and Designmentioning

confidence: 99%

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Functional Reorganization of the Visual Dorsal Stream as Probed by 3-D Visual Coherence in Williams Syndrome

Bernardino

Rebola

Farivar

et al. 2014

Journal of Cognitive Neuroscience

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Object and depth perception from motion cues involves the recruitment of visual dorsal stream brain areas. In 3-D structure-from-motion (SFM) perception, motion and depth information are first extracted in this visual stream to allow object categorization, which is in turn mediated by the ventral visual stream. Such interplay justifies the use of SFM paradigms to understand dorsal-ventral integration of visual information. The nature of such processing is particularly interesting to be investigated in a neurological model of cognitive dissociation between dorsal (impaired) and ventral stream (relatively preserved) processing, Williams syndrome (WS). In the current fMRI study, we assessed dorsal versus ventral stream processing by using a performance-matched 3-D SFM object categorization task. We found evidence for substantial reorganization of the dorsal stream in WS as assessed by whole-brain ANOVA random effects analysis, with subtle differences in ventral activation. Dorsal reorganization was expressed by larger medial recruitment in WS (cuneus, precuneus, and retrosplenial cortex) in contrast with controls, which showed the expected dorsolateral pattern (caudal intraparietal sulcus and lateral occipital cortex). In summary, we found a substantial reorganization of dorsal stream regions in WS in response to simple visual categories and 3-D SFM perception, with less affected ventral stream. Our results corroborate the existence of a medial dorsal pathway that provides the substrate for information rerouting and reorganization in the presence of lateral dorsal stream vulnerability. This interpretation is consistent with recent findings suggesting parallel routing of information in medial and lateral parts of dorsal stream.

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The dual facet of gamma oscillations: Separate visual and decision making circuits as revealed by simultaneous EEG/fMRI

Castelhano

Duarte

Wibral

et al. 2014

Human Brain Mapping

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It remains an outstanding question whether gamma-band oscillations reflect unitary cognitive processes within the same task. EEG/MEG studies do lack the resolution or coverage to address the highly debated question whether single gamma activity patterns are linked with multiple cognitive modules or alternatively each pattern associates with a specific cognitive module, within the same coherent perceptual task. One way to disentangle these issues would be to provide direct identification of their sources, by combining different techniques. Here, we directly examined these questions by performing simultaneous EEG/fMRI using an ambiguous perception paradigm requiring holistic integration. We found that distinct gamma frequency sub-bands reflect different neural substrates and cognitive mechanisms when comparing object perception states vs. no categorical perception. A low gamma sub-band (near 40 Hz) activity was tightly related to the decision making network, and in particular the anterior insula. A high gamma sub-band (∼60 Hz) could be linked to early visual processing regions. The demonstration of a clear functional topography for distinct gamma sub-bands within the same task shows that distinct gamma-band modulations underlie sensory processing and perceptual decision mechanisms.

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Neural correlates of visual integration in Williams syndrome: Gamma oscillation patterns in a model of impaired coherence

Cited by 15 publications

References 52 publications

Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study

Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study

Functional Reorganization of the Visual Dorsal Stream as Probed by 3-D Visual Coherence in Williams Syndrome

The dual facet of gamma oscillations: Separate visual and decision making circuits as revealed by simultaneous EEG/fMRI

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