Application of comprehensive two-dimensional gas chromatography with mass spectrometric detection for the analysis of selected drug residues in wastewater and surface water

Lacina, Petr; Mravcová, Ludmila; Vávrová, Milada

doi:10.1016/s1001-0742(12)60006-0

Cited by 49 publications

(26 citation statements)

References 39 publications

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“…pets, cattle…) and humans that can also be exposed in some geographical areas to relatively high levels of drugs by way of contaminated foodstuff and water. Interestingly, concentrations as high as 0.01 and 0.1 mg/L have been found in different studies in wastewater, or in surface water (Daughton and Ternes, ; Gomez et al, ; Lin et al, ; Terzic et al, ; Lacina et al, ). In these investigations, numerous types of drugs were detected such as analgesics and nonsteroidal anti‐inflammatory drugs (e.g., acetaminophen, salicylic acid, ibuprofen, diclofenac), antibiotics (e.g., lincomycin, cefazolin, sulfamethoxazole), X‐ray contrast agents (e.g., diatrizoate and iopamidol) and caffeine.…”

Section: Introductionmentioning

confidence: 98%

Chronic and low exposure to a pharmaceutical cocktail induces mitochondrial dysfunction in liver and hyperglycemia: Differential responses between lean and obese mice

Buron

Porceddu

Roussel

et al. 2016

Environmental Toxicology

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Pharmaceuticals are found in the environment but the impact of this contamination on human and animal health is poorly known. The liver could be particularly targeted since a significant number of these drugs are hepatotoxic, in particular via oxidative stress and mitochondrial dysfunction. Notably, the latter events can also be observed in liver diseases linked to obesity, so that the obese liver might be more sensitive to drug toxicity. In this study, we determined the effects of a chronic exposure to low doses of pharmaceuticals in wild-type and obese mice, with a particular focus on mitochondrial function. To this end, wild-type and ob/ob mice were exposed for 4 months to a cocktail of 11 pharmaceuticals provided in drinking water containing 0.01, 0.1, or 1 mg/L of each drug. At the end of the treatment, liver mitochondria were isolated and different parameters were measured. Chronic exposure to the pharmaceuticals reduced mitochondrial respiration driven by succinate and palmitoyl-l-carnitine in wild-type mice and increased antimycin-induced ROS production in ob/ob mice. Hyperglycemia and hepatic histological abnormalities were also observed in treated ob/ob mice. Investigations were also carried out in isolated liver mitochondria incubated with the mixture, or with each individual drug. The mitochondrial effects of the mixture were different from those observed in treated mice and could not be predicted from the results obtained with each drug. Because some of the 11 drugs included in our cocktail can be found in water at relatively high concentrations, our data could be relevant in environmental toxicology. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1375-1389, 2017.

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Section: Introductionmentioning

confidence: 98%

Chronic and low exposure to a pharmaceutical cocktail induces mitochondrial dysfunction in liver and hyperglycemia: Differential responses between lean and obese mice

Buron

Porceddu

Roussel

et al. 2016

Environmental Toxicology

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“…In groundwater environment, the septic system failure could be the main source of pollution with pharmaceuticals [6]. The residue of caffeine in surface water usually traced at low level concentrations within the range of ng/L to µg/L [7,8]. Nevertheless, it is still threatening to aquatic ecosystem especially living organism likes coral, which is highly sensitive to caffeine [9].…”

Section: Introductionmentioning

confidence: 99%

“…Analysis of caffeine residue in natural waters have been carried in many countries by using various instruments mainly by liquid chromatography [3,5,17] and gas chromatography [7,18,19]. However, information of caffeine residue present in Malaysian environment is still limited and unclear.…”

Section: Introductionmentioning

confidence: 99%

Determination of Caffeine in Surface Water Using Solid Phase Extraction and High Performance Liquid Chromatography

Al-Qaim

Jusof

Abdullah³

et al. 2017

MJAS

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A new analytical method development based on solid phase extraction (SPE) combined with high performance liquid chromatography (HPLC) was carried out. The optimum working conditions were obtained based on selection of 250 mL sample loading, 0.25 µL methanol as reconstitution solvent, 100% methanol as mobile phase and 270 nm as the optimum wavelength. Good linearity was obtained in the range of 0.015 -400 mg/L and the regression coefficient, R 2 , was 0.995. Limit of detection and quantification were calculated at LOD = 0.06 µg/L and LOQ = 0.2 µg/L respectively. Repeatability and robustness has showed good performance with low relative standard deviation less than 3.29% and 3.50% respectively. Time-of-flight mass spectrometry (TOF/MS) instrument was used to confirm that caffeine is definitely present in surface water with level of concentration ranged from 31.7 to 50.1 µg/L. All results were analyzed statistically using one-way ANOVA, Tukey with interval confidence 95% and P-value 0.05.Keywords: caffeine, stimulant, emerging pollutant, water quality, time of flight/mass spectrometry Abstrak Pembangunan kaedah analisis baru berasaskan pengekstrakan fasa pepejal bersama kromatografi cecair prestasi tinggi (KPCT) telah dijalankan. Kaedah optimum diperolehi berdasarkan tetapan iaitu 250 mL muatan sampel, 0.25 µL metanol sebagai pelarut, 100% methanol sebagai fasa bergerak dan 270 nm panjang gelombang yang optimum. Nilai kelinearan baik diperolehi pada julat kepekatan 0.015 -400 mg/L dan nilai pekali regresi, R 2 ialah 0.995. Had pengesanan dan kuantifikasi dihitung masing -masing pada LOD = 0.06 µg/L and LOQ = 0.2 µg/L. Kebolehulangan dan keteguhan kaedah menunjukkan prestasi baik dengan nilai sisihan piawai relatif yang rendah iaitu masing -masing kurang daripada 3.29% dan 3.50%. Spektrometri jisim masa penerbangan (TOF/MS) digunakan untuk mengesahkan kehadiran kafein di permukaan air dengan aras kepekatan antara julat 31.7 hingga 50.1 µg/L. Keputusan dianalisa mengunakan pendekatan statistik seperti ANOVA satu hala, Tukey dengan aras keyakinan 95% and nilai p 0.05.Kata kunci: kafein, perangsang, pencemar baru, kualiti air, spektrometri jisim/masa penerbangan

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“…La presencia de los productos farmacéuticos en el medio ambiente se observó por primera vez en la década de 1980, algunos residuos farmacéuticos se detectaron en afluentes y efluentes de plantas de tratamiento de aguas residuales domésticas y en aguas superficiales (Lacina et al, 2013). De igual manera, se han detectado concentraciones medibles de hormonas y antibióticos en el suelo y las aguas subterráneas y superficiales que reciben el escurrimiento de los campos fertilizados con estiércol y aguas abajo de las operaciones con animales de granja, generados por el uso excesivo de antibióticos en la industria ganadera y el cambio espectacular en los últimos años a concentrados alimenticios para animales, lo que conlleva al aumento concomitante en el volumen de los desechos animales por unidad de superficie (Lee et al, 2009;Cai et al, 2012).…”

Section: Introductionunclassified

Regulación ambiental sobre los productos farmacéuticos residuales en ambientes acuáticos

Rubio

Delgado

2015

Entornos

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Los productos farmacéuticos activos representan un grupo de contaminantes, que aunque en pequeñas cantidades en el medio ambiente, son motivo de preocupación ya que están diseñados para ser intrínseca y biológicamente activos y potencialmente estables en virtud de los procesos metabólicos. Hoy en día, se reconoce por la comunidad científica que laexposición continua de dosis bajas de productos farmacéuticos puede producir efectos a largo plazo sobre el medio ambiente como consecuencia de posibles daños irreversibles del ecosistema y la salud humana (Silva et al; 2012. Rahman et al; 2009a). Debido a la alta polaridad y baja volatilidad, la mayoría de los productos farmacéuticos tienden a ser fácilmente transportados y descargados en los cuerpos de agua (Zhang et al, 2014).

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Application of comprehensive two-dimensional gas chromatography with mass spectrometric detection for the analysis of selected drug residues in wastewater and surface water

Cited by 49 publications

References 39 publications

Chronic and low exposure to a pharmaceutical cocktail induces mitochondrial dysfunction in liver and hyperglycemia: Differential responses between lean and obese mice

Chronic and low exposure to a pharmaceutical cocktail induces mitochondrial dysfunction in liver and hyperglycemia: Differential responses between lean and obese mice

Determination of Caffeine in Surface Water Using Solid Phase Extraction and High Performance Liquid Chromatography

Regulación ambiental sobre los productos farmacéuticos residuales en ambientes acuáticos

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