Carbon Dioxide Laser Treatment in Hailey-Hailey Disease: A Series of 8 Patients

Pretel, Maider; Lera-Imbuluzqueta, J.M.; España-Alonso, A.

doi:10.1016/j.adengl.2013.03.004

Cited by 10 publications

(31 citation statements)

References 32 publications

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“…Treatment of HHD with a continuous CO 2 laser in defocused mode offers several advantages over the most widely used treatment modalities for HHD. The CO 2 laser can selectively vapourize tissue at a superficial level (0.08–0.15 mm) . Therefore, a large surface area can be treated in a short period of time.…”

Section: Discussionmentioning

confidence: 99%

“…After healing, histopathology shows normal epithelium with some scarring in the upper dermis. It is believed that the eccrine glands with patent acrosyringium are responsible for epidermal reepithelialization and granulation …”

Section: Discussionmentioning

confidence: 99%

“…Treatment parameters for CO 2 lasers depend on the thickness of the skin to be treated. To minimize collateral tissue damage, pulse duration should be shorter than thermal relaxation time, which is 200–600 ms for skin . When this is taken into consideration, the depth of ablation would be 80–100 μm with two passes and 150 μm with three passes .…”

Section: Discussionmentioning

confidence: 99%

“…suggested that treatment should extend beyond clinically visible disease . Although these areas may improve with time, they can be alternatively treated in additional sessions . The main limitation of laser treatments was pain, which was avoided with appropriate anaesthesia.…”

Section: Discussionmentioning

confidence: 99%

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Laser therapy for the treatment of Hailey–Hailey disease: a systematic review with focus on carbon dioxide laser resurfacing

Falto‐Aizpurua

Griffith

Abyaneh

et al. 2014

Acad Dermatol Venereol

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Benign familial chronic pemphigus, or Hailey-Hailey disease (HHD), is a recurrent bullous dermatitis that tends to have a chronic course with frequent relapses. Long-term treatment options include surgery with skin grafting or dermabrasion. Both are highly invasive and carry significant risks and complications. More recently, 'laser-abrasion' has been described as a less invasive option with a better side-effect profile. In this article, we systematically review the safety and efficacy of carbon dioxide laser therapy as a long-term treatment option for HHD, as well as provide a review of other lasers that have been reported with this goal. A total of 23 patients who had been treated with a carbon dioxide laser were identified. After treatment, 10 patients (43%) had had no recurrence, 10 (43%) had greater than 50% improvement, 2 (8%) had less than 50% improvement and 1 (4%) patient had no improvement at all (follow-up period ranged from 4 to 144 months). Laser parameter variability was wide and adverse effects were minimal, including dyspigmentation and scarring. Reviewed evidence indicates this therapy offers a safe, effective treatment alternative for HHD with minimal risk of side-effects. Larger, well-designed studies are necessary to determine the optimal treatment parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Laser therapy for the treatment of Hailey–Hailey disease: a systematic review with focus on carbon dioxide laser resurfacing

Falto‐Aizpurua

Griffith

Abyaneh

et al. 2014

Acad Dermatol Venereol

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show abstract

“…These can be carbon dioxide laser ablation, cryotherapy, dermabrasion, electrosurgery, excision and grafting. 4,35 There are reports in the literature of successful treatments with Er:YAG laser, argon plasma coagulation, electron beam radiotherapy, cold atmospheric plasma, melanocortin analogue called afamelanotide and topical calcitriol, tacalcitol and fluorouracil (Table 1). 36,37,38,39,40,41,42,43 Prognosis…”

Section: Differential Diagnosismentioning

confidence: 98%