Fractionated 5-aminolevulinic acid photodynamic therapy after partial debulking versus surgical excision for nodular basal cell carcinoma: A randomized controlled trial with at least 5-year follow-up

Roozeboom, Marieke H.; Aardoom, M; Nelemans, Patty J.; Thissen, M. R. T. M.; Kelleners‐Smeets, Nicole W.J.; Kuijpers, Daniëlle; Mosterd, Klara

doi:10.1016/j.jaad.2013.02.014

Cited by 87 publications

(82 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…87 In a similar study, 2 PDT illuminations were performed with ALA-PDT after debulking of nodular BCC, with a cumulative recurrence rate of 31% after 5 years and best response in small BCC less than 0.7 mm thick. 38 Other data with ALA-PDT are similar, with complete response rates of at least 60% to 70% and improved response when light irradiation was fractionated into 2 periods of illumination. 82 Studies directly comparing ALA-PDT and MAL-PDT have reported similar effectiveness for treatment of BCC with these therapies.…”

Section: Photodynamic Therapymentioning

confidence: 77%

“…3 Multiple RCTs comparing standard surgical excision of BCC with topical medical therapy, C&E, photodynamic therapy (PDT), cryotherapy, radiation therapy, and MMS have been published. 32,[34][35][36][37][38][39] All the studies consistently reported low recurrence rates after standard excision of BCC with predominantly nonaggressive histologic growth patterns. Excision of nodular or superficial BCC with 3-to 4-mm margins in low-risk anatomic locations was associated with 2% to 4% recurrence rates after 3 to 5 years.…”

Section: Standard Excisionmentioning

confidence: 94%

“…Excision of nodular or superficial BCC with 3-to 4-mm margins in low-risk anatomic locations was associated with 2% to 4% recurrence rates after 3 to 5 years. 35,[38][39][40] In a study comparing standard excision with C&E followed by cryosurgery for nonaggressive BCC on the head and neck, the 5-year recurrence rates were 8.2% and 17.6%, respectively. 36 Recurrence rates following surgical excision were uniformly significantly lower than those following treatment with topical therapy, radiation therapy, or destructive modalities.…”

Section: Standard Excisionmentioning

confidence: 99%

“…35,38,64,74,76,77,[80][81][82]86,87,99 Application of the photosensitizer is often preceded by light curettage of BCCs. 99 Usually a single treatment cycle is performed, but treatments may be repeated.…”

Section: Photodynamic Therapymentioning

confidence: 99%

“…35,38,99 Cure rates after surgical excision are 10% to 20% higher than those for topical therapies, including PDT, with excision associated with recurrence rates of less than 5%. Surgical excision may also be less painful and better tolerated.…”

Section: Comparative Effectiveness Of Topical Therapiesmentioning

confidence: 99%

See 4 more Smart Citations

Guidelines of care for the management of basal cell carcinoma

Baum¹,

Bordeaux²,

Brown³

et al. 2018

Journal of the American Academy of Dermatology

310

219

View full text Add to dashboard Cite

Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. We discuss biopsy techniques for a clinically suspicious lesion and offer recommendations for the histopathologic interpretation of BCC. In the absence of a formal staging system, the best available stratification based on risk for recurrence is reviewed. With regard to treatment, we provide recommendations on treatment modalities along a broad therapeutic spectrum, ranging from topical agents and superficially destructive modalities to surgical techniques and systemic therapy. Finally, we review the available literature and provide recommendations on prevention and the most appropriate follow-up for patients in whom BCC has been diagnosed. ( J Am Acad Dermatol

show abstract

Section: Photodynamic Therapymentioning

confidence: 77%

Section: Standard Excisionmentioning

confidence: 94%

Section: Standard Excisionmentioning

confidence: 99%

Section: Photodynamic Therapymentioning

confidence: 99%

Section: Comparative Effectiveness Of Topical Therapiesmentioning

confidence: 99%

See 3 more Smart Citations

Guidelines of care for the management of basal cell carcinoma

Baum¹,

Bordeaux²,

Brown³

et al. 2018

Journal of the American Academy of Dermatology

310

219

View full text Add to dashboard Cite

show abstract

Interventions for basal cell carcinoma of the skin

Thomson

Hogan

Leonardi‐Bee

et al. 2020

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

Surgical excision, Mohs micrographic surgery, external‐beam radiotherapy, or brachytherapy for indolent skin cancer: An international meta‐analysis of 58 studies with 21,000 patients

Lee

Lehrer

Aphale

et al. 2019

Cancer

View full text Add to dashboard Cite

BACKGROUND:The objective of this study was to compare the cosmesis and recurrence rates of conventional excision (CE), Mohs micrographic surgery (MMS), external-beam radiation therapy (EBRT), or brachytherapy (BT), for basal cell carcinoma and squamous cell carcinoma of the skin. METHODS: Population, Intervention, Control, Outcome, Study Design (PICOS), Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and Meta-Analyses of Observational Studies in Epidemiology (MOOSE) methods were used to identify studies on PubMed (from 1985 to 2018), including patients with American Joint Committee on Cancer (AJCC) T1-T2N0 basal cell carcinomas and squamous cell carcinomas and ≥10 months follow-up who received CE, MMS, EBRT, or BT. The primary endpoint was cosmesis, classified as "good," "fair," or "poor." The secondary endpoint was 1-year recurrence. Fixed-effects and random-effects meta-analyses were performed to evaluate primary and secondary outcomes with respect to treatment modality. RESULTS: In total, 18,095 studies met initial search criteria. There were 24 CE, 13 MMS, 19 EBRT, and 7 BT studies included with a total of 21,371 patients. The summary effect size for "good" cosmesis was 81% (95% CI, 70.6%-89.6%), 74.6% (95% CI, 63%-84.6%), and 97.6% (95% CI, 91.3%-100%) for CE, EBRT, and BT, respectively. Good cosmesis was 96.0% in the only MMS study that reported cosmesis. BT had improved "good" cosmesis over EBRT (P = .0025) and was similar to CE and MMS. No significant differences were seen for "fair" or "poor" cosmesis. One-year recurrence rates were low throughout at 0.8% (95% CI, 0.3%-1.6%), 0.2% (95% CI, 0%-0.6%), 2% (95% CI, 1.3%-2.7%), and 0% (95% CI, 0%-0.5%) for CE, MMS, EBRT, and BT, respectively. CONCLUSIONS: For T1-T2N0 skin cancers, BT and MMS have improved cosmesis over EBRT and CE. It is unclear whether this is because of treatment superiority or selection and reporting bias. Local control is similar among all modalities at 1 year. Cancer 2019;125:3582-3594.

show abstract

Fractionated 5-aminolevulinic acid photodynamic therapy after partial debulking versus surgical excision for nodular basal cell carcinoma: A randomized controlled trial with at least 5-year follow-up

Cited by 87 publications

References 38 publications

Guidelines of care for the management of basal cell carcinoma

Guidelines of care for the management of basal cell carcinoma

Interventions for basal cell carcinoma of the skin

Surgical excision, Mohs micrographic surgery, external‐beam radiotherapy, or brachytherapy for indolent skin cancer: An international meta‐analysis of 58 studies with 21,000 patients

Contact Info

Product

Resources

About