A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Comparing the Efficacy of Systemic Enzyme Therapy for Edema Control in Orthognathic Surgery Using Ultrasound Scan to Measure Facial Swelling

Shetty, Vikram; Mohan, Akhilesh

doi:10.1016/j.joms.2013.01.008

Cited by 35 publications

(19 citation statements)

References 21 publications

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“…Thus, a direct correlation was observed between the use of Venoplant Ò and the decrease in postoperative swelling. In literature the edema of midface is lower than the edema of the mandibular region after orthognathic surgery [11].…”

Section: Discussionmentioning

confidence: 93%

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A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Comparing the Efficacy of Anti-edema Drugs for Edema Control in Orthognathic Surgery Using Digitizer 3-D to Measure Facial Swelling

Tozzi¹,

Santillo

Tartaro

et al. 2014

J. Maxillofac. Oral Surg.

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Introduction Orthognathic surgery involves making several osteotomies. Any osteotomies leads to varying degrees of post-operative swelling. The aim of this study was to evaluate the effectiveness of anti-edema drugs for the control of edema, using Digitizer 3D TM for measuring softtissue thickness, in patients who underwent bimaxillaryorthognathic surgery. Materials and Methods In this double-blinded, randomized, control trial, 24 patients (study group: 12 patients, control group: 12 patients) in whom bimaxillary orthognathic surgery was indicated, were included in this study. All swelling measurements were expressed as total 3-D area of the landmarks (cm 2 ) in T0 pre-operative, T1 first day after surgery, T2 fourth day after surgery, T3 4 months after surgery. For each patient we compared, by adding left and right area, the increase of swelling between T1-T0, T2-T0 and T1-T3. Results The differences T0-T1 are highly significant (p \ 0.01) between group 1 or study group (treated with Venoplant Ò ) and group 2 (control group); the differences T0-T2 are significant (p \ 0.05) between group 1 (treated with Venoplant Ò ) and group 2 (control group). The differences T1-T3 are significant (p \ 0.05) between group 1 (treated with Venoplant Ò ) and group 2 (control group). Discussion The present study suggests that Venoplant Ò significantly decreases postoperative edema in orthognathic surgery, thus precluding long-term corticosteroid use.

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Section: Discussionmentioning

confidence: 93%

“…Medical management of swelling in orthognathic surgery is confined mainly to the use of steroids or non-steroidal anti-inflammatory drugs. The use of systemic enzyme therapy (SET) for edema control in orthognathic surgery is not well established in the literature [11].…”

Section: Introductionmentioning

confidence: 99%

A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Comparing the Efficacy of Anti-edema Drugs for Edema Control in Orthognathic Surgery Using Digitizer 3-D to Measure Facial Swelling

Tozzi¹,

Santillo

Tartaro

et al. 2014

J. Maxillofac. Oral Surg.

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“…In addressing the causal effect between steroid use and studied outcomes, future endeavors should also consider the multifactorial parameters that can confound the degree soft tissue edema such as the duration of tissue manipulation, extent of dissection, whether the scalp is reflected during surgery, amount of blood loss, routine dexamethasone use as an antiemetic protocol, and total volume of infused fluids. 12,30,31 These were not addressed in our identified studies.…”

Section: Limitationsmentioning

confidence: 96%

Does Perioperative Steroid Use Improve Clinical Outcomes in Open Repair of Craniosynostosis?

Wei¹,

Madsen²,

Al-Sheemy³

et al. 2015

Journal of Craniofacial Surgery

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“…Five studies reported improvement of ecchymosis and/or edema after use of bromelain post procedure. [36][37][38][39][40] Two studies revealed no improvement for use of bromelain post procedure. 41,42 Analysis and Recommendation Three RCTs noted significant improvement of ecchymosis and edema post facial procedures, and 2 RCTs demonstrated similar positive findings post dental procedures.…”

Section: Clinical Trials Of Bromelain For Prevention Of Post-procedurmentioning

confidence: 99%

Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature

Jagdeo

Waldorf

2016

Dermatologic Surgery

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A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Comparing the Efficacy of Systemic Enzyme Therapy for Edema Control in Orthognathic Surgery Using Ultrasound Scan to Measure Facial Swelling

Cited by 35 publications

References 21 publications

A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Comparing the Efficacy of Anti-edema Drugs for Edema Control in Orthognathic Surgery Using Digitizer 3-D to Measure Facial Swelling

A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Comparing the Efficacy of Anti-edema Drugs for Edema Control in Orthognathic Surgery Using Digitizer 3-D to Measure Facial Swelling

Does Perioperative Steroid Use Improve Clinical Outcomes in Open Repair of Craniosynostosis?

Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature

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