Obesity may increase the occurrence of spontaneous periodontal disease in Wistar rats

Cavagni, Juliano; Wagner, Tassiane Panta; Gaio, Eduardo José; Rêgo, Rodrigo Otávio; Torres, Iraci Lucena da Silva; Rösing, Cassiano Kuchenbecker

doi:10.1016/j.archoralbio.2013.03.006

Cited by 39 publications

(45 citation statements)

References 31 publications

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“…A difference of approximately 24% in body weight was observed between PF rats and CO rats. This body weight difference has been assumed in the literature as inferring obesity [26]. Except for body weight, the Lee Index in PF rats displayed a statistically significant difference compared with rats of CO and PO.…”

Section: Discussionmentioning

confidence: 59%

The Characterization of Obese Polycystic Ovary Syndrome Rat Model Suitable for Exercise Intervention

Feng

Qiu

et al. 2014

PLoS ONE

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ObjectiveTo develop a new polycystic ovary syndrome (PCOS) rat model suitable for exercise intervention.MethodThirty six rats were randomly divided into three experimental groups: PCOS rats with high-fat diet (PF, n = 24), PCOS rats with ordinary diet (PO, n = 6), and control rats with ordinary diet (CO, n = 6). Two kinds of PCOS rat model were made by adjustment diet structure and testosterone injection for 28 days. After a successful animal model, PF model rats were randomly assigned to three groups: exercise with a continuation of high-fat diet (PF-EF, n = 6), sedentary with a continuation of high-fat diet (PF-SF, n = 6), exercise with an ordinary diet (PF-EO, n = 6). Fasting blood glucose (FBG) and insulin (FINS), estrogen (E2), progesterone (P), and testosterone (T) in serum were determined by RIA, and ovarian morphology was evaluated by Image-Pro plus 6.0.ResultsBody weight, Lee index, FINS increased significantly in PF rat model. Serum levels of E2 and T were significantly higher in PF and PO than in CO. Ovary organ index and ovarian areas were significant lower in PF than in CO. After intervention for 2 weeks, the levels of 1 h postprandial blood glucose (PBG1), 2 h postprandial blood glucose (PBG2), FINS and the serum levels of T decreased significantly in PF-EF rats and PF-EO rats. The ratio of FBG/FINS was significant higher in PF-EO rats than in PF-SF rats. Ovarian morphology showed that the numbers of preantral follicles and atretic follicles decreased significantly, and the numbers of antral follicles and corpora lutea increased significantly in the rats of PF-EF and PF-EO.ConclusionBy combination of high-fat diet and testosterone injection, the obese PCOS rat model is conformable with the lifestyle habits of fatty foods and insufficient exercise, and has metabolic and reproductive characteristics of human PCOS. This model can be applied to study exercise intervention.

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Section: Discussionmentioning

confidence: 59%

The Characterization of Obese Polycystic Ovary Syndrome Rat Model Suitable for Exercise Intervention

Feng

Qiu

et al. 2014

PLoS ONE

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“…Furthermore, periodontal diseases themselves could be modulated by alteration of gut microbiota-induced systemic inflammation. In support of this hypothesis, it has been reported that high-fat diet-induced obesity increased alveolar bone resorption, a characteristic feature of periodontitis4445.…”

Section: Discussionmentioning

confidence: 79%

Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota

Arimatsu

Yamada

Miyazawa

et al. 2014

Sci Rep

437

447

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Periodontitis has been implicated as a risk factor for metabolic disorders such as type 2 diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty liver disease. Although bacteremias from dental plaque and/or elevated circulating inflammatory cytokines emanating from the inflamed gingiva are suspected mechanisms linking periodontitis and these diseases, direct evidence is lacking. We hypothesize that disturbances of the gut microbiota by swallowed bacteria induce a metabolic endotoxemia leading metabolic disorders. To investigate this hypothesis, changes in the gut microbiota, insulin and glucose intolerance, and levels of tissue inflammation were analysed in mice after oral administration of Porphyromonas gingivalis, a representative periodontopathogens. Pyrosequencing revealed that the population belonging to Bacteroidales was significantly elevated in P. gingivalis-administered mice which coincided with increases in insulin resistance and systemic inflammation. In P. gingivalis-administered mice blood endotoxin levels tended to be higher, whereas gene expression of tight junction proteins in the ileum was significantly decreased. These results provide a new paradigm for the interrelationship between periodontitis and systemic diseases.

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“…This is related to the fact that most studies that evaluated etiopathogenic processes of periodontal diseases in rodents used different disease induction models, 31 which may be, in some cases, more extreme than the natural occurrence of periodontitis. Therefore, these experimental models have recently been criticized and investigated, especially by taking into consideration the possibility of observing periodontal breakdown without any “external” challenge 3 , 4 . The present results indicate that some CC lines showed a significant “spontaneous” bone loss in response to an HFD consumption despite the absence of classic periodontal disease induction such as ligatures, bacteria, etc.…”

Section: Discussionmentioning

confidence: 79%

“…Periodontitis is considered to be one of the most common inflammatory diseases in humans, resulting in destruction of tooth‐supporting tissues and irreversible alveolar bone loss (ABL) and leading, in some cases, to tooth loss 1 . Today, it is evident that susceptibility to periodontitis is attributed to interplay of both host genetic background 2 and environmental factors, including lifestyle, obesity, and high‐fat diet (HFD) 3 , 4 . Type 2 diabetes mellitus (t2DM) is a complex metabolic disease that is characterized by hyperglycemia resulting from insulin resistance.…”

mentioning

confidence: 99%

Collaborative Cross Mouse Population for Studying Alveolar Bone Changes and Impaired Glucose Tolerance Comorbidity After High‐Fat Diet Consumption

Nashef

Atamni

Buchnik

et al. 2017

Journal of Periodontology

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Obesity may increase the occurrence of spontaneous periodontal disease in Wistar rats

Cited by 39 publications

References 31 publications

The Characterization of Obese Polycystic Ovary Syndrome Rat Model Suitable for Exercise Intervention

The Characterization of Obese Polycystic Ovary Syndrome Rat Model Suitable for Exercise Intervention

Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota

Collaborative Cross Mouse Population for Studying Alveolar Bone Changes and Impaired Glucose Tolerance Comorbidity After High‐Fat Diet Consumption

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