Identification and antifungal susceptibility of fungi isolated from dermatomycoses

Abstract

Yeasts, particularly C. parapsilosis, play an important role as causative agents of dermatomycosis in our region. Our results suggest that the antifungal susceptibility testing coupled with proper identification of the fungi may be useful to assist clinicians in determining the appropriate therapy for dermatomycoses.

Study of Pattern of Emerging Antifungal Resistance in A Zonal Hospital in North-East India.

“…13,14 Voriconazole and Itraconazole were the most effective antifungals in our study across all species. This is in line with previous studies 15 . Many earlier studies have quoted a resistance rate of 1.7% to 6% to Itraconazole.…”

Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples

“…Similarly, FLC resistance in C. metapsilosis and C. parapsilosis sensu stricto has been observed by Chen et al (40) Moreover, Gomez-Lopez et al (41) found an MIC of greater than 4µg/mL FLC for these species, while Silva et al (6) found an MIC of 16µg/mL FLC for one C. parapsilosis sensu stricto isolate. According to Van Asbeck et al (42) , the differences in FLC susceptibility may also refl ect the different affi nities of azoles for the key ergosterol-synthesizing enzyme 14-α-demethylase or for other enzymes in this pathway.…”

“…In contrast, similar to our results, Ge et al (19) have found that C. parapsilosis sensu stricto and C. metapsilosis are the agents responsible for onychomycosis. Among C. parapsilosis complex species, the two species newly identifi ed as C. orthopsilosis and C. metapsilosis have been less frequently isolated from patients with onychomycosis (6) (36) .…”

“…Candida parapsilosis is a common yeast species found in cases of onychomycosis and candidemia associated with infected intravascular devices (3) (4) (5) (6) . In State of Goiás, Brazil, C. parapsilosis was found in 52.5% of nail samples and was the second most commonly isolated species (24.2%) from blood cultures (4) (7) .…”

Antifungal Activity of Dihydrobenzofuran Neolignans

“…[4][5][6] The responsible for the dermatomycoses is pointed out as dermatophytes, non-dermatophytic filamentous and yeasts forms of fungi, but in most of the cases, the etiologic agents are the dermatophytes. 7 Furthermore, the species causative of dermatomycoses demonstrate considerable variation depending on the geographical location, economic situations as well as population migrations and weather conditions, and can affect the treatment of such fungal infections. 1,6,8 Besides the dermatomycoses have been increased over the years, the known treatment available for these diseases is still based on the use of triazoles (fluconazole, itraconazole, voriconazole), imidazoles (ketoconazole), allylamines (terbinafine) and griseofulvin.…”