Recent advances in adrenocortical carcinoma in adults

Bourdeau, Isabelle; Mackenzie-Feder, Jessica; Lacroix, André

doi:10.1097/med.0b013e3283602274

Cited by 45 publications

(41 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adrenocortical carcinoma typically metastasizes to the lung, liver, peritoneum and pleura, lymph nodes, and bones (22). Prognosis is considerably poor, and the 5-year overall survival rate of advanced adrenocortical carcinoma is <30% (23). Even with favorably performed radical resections, the majority of patients succumb to local recurrence or de novo metastases (2,8,21).…”

Section: Discussionmentioning

confidence: 99%

Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature

Zhu¹,

Zheng²,

Mao³

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. Adrenal sarcomatoid carcinoma is a rare adrenal carcinoma. To the best of our knowledge, only 11 cases have been reported since 1987. Adrenal sarcomatoid carcinoma presents a diagnostic challenge due to its atypical symptoms and histological patterns. At the time of diagnosis, a large percentage of patients are already at the metastatic stage and succumb within a few months. The present study reports a case of a 59-year-old man presenting with asthenia and weight loss with adrenal sarcomatoid carcinoma metastatic to the lung. A computed tomography (CT) scan and ultrasonography of the patient's abdomen suggested a large homogeneous mass in the right adrenal gland, and a CT scan of his chest suggested lung metastasis. Right adrenalectomy was performed. Histological examination revealed that the tumor was composed of sarcomatous and carcinomatous differentiation elements. Immunohistochemical examination revealed tumor cell positivity for vimentin and cytokeratin. At the 6-month follow-up the patient exhibited no disease progression and refused further proposed treatment. The patient was alive at the time of writing the current report. The present case report additionally reviews the literature, for the purpose of raising awareness of these rare lesions and assisting in achieving accurate diagnoses and effective treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature

Zhu¹,

Zheng²,

Mao³

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…Tali livelli sono anche predittivi di sopravvivenza prolungata (53). Oltre al suo effetto antitumorale, il mitotane è anche un potente inibitore della steroidogenesi surrenalica e ha un'indicazione in pazienti con ipersecrezione endocrina, anche se il suo successo nel controllo della secrezione ormonale non è ancora ben noto (2,3). La lunga latenza che il mitotane dimostra nel raggiungere i livelli terapeutici lo rende un farmaco adatto in monoterapia solo nei pazienti con neoplasie indolenti e poco aggressive.…”

Section: Chemioterapia E Mitotane Per Il Ccs Metastaticounclassified

“…I pazienti dovrebbero quindi essere gestiti da un team multidisciplinare in centri con strutture adeguate (1)(2)(3)(6)(7)(8).…”

Section: Introduzioneunclassified

Diagnosi e terapia del carcinoma corticosurrenalico

et al. 2014

View full text Add to dashboard Cite

RIASSUNTOIl carcinoma corticosurrenalico (CCS) è un tumore raro e molto aggressivo. Al momento attuale non sono stati individuati approcci terapeutici personalizzati, ad esclusione della terapia con mitotane guidata dal dosaggio plasmatico del farmaco.L'intervento chirurgico radicale è l'unico approccio potenzialmente curativo.Obiettivo del presente articolo è rivedere le conoscenze attuali relative alla diagnosi, alla gestione dei pazienti dopo chirurga radicale e alla gestione delle forme di malattia avanzata.

show abstract

“…Among pathologic parameters, the disease stage at initial diagnosis and a margin-free resection have been consid-ered the most important and validated prognostic factors [56][57][58][59] because it still represents the only curative treat-ment for ACC [60,61]. Stage at diagnosis is a key prognos-tic factor also because feasibility of radical surgery depends heavily on disease extent.…”

Section: Pathologic Prognostic Parametersmentioning

confidence: 99%