Meta-analysis demonstrates lack of a relationship between XRCC1-399 gene polymorphisms and susceptibility to hepatocellular carcinoma

The XRCC1 Arg399Gln Genetic Polymorphism Contributes to Hepatocellular Carcinoma Susceptibility: An Updated Meta-analysis

“…Regarding to HCC, the correlations between XRCC1 polymorphisms and HCC susceptibility were also conflicting. Three previous meta-analyses found no association of XRCC1 Arg399Gln polymorphism with HCC susceptibility Xie et al, 2012;Zeng et al, 2013) while other two studies got the inverse results that XRCC1 Arg399Gln polymorphism had significant contributions to HCC risk (Zhang et al, 2010;Li et al, 2013). However, there were some common problems in these previous meta-analyses such as data duplicates, data missing and inclusion of studies with unsatisfied HWE of the controls.…”

“…Based on these studies, five metaanalyses were performed in last five years. However, the conclusions are unconvincing because of data duplications or data missing Xie et al, 2012;Li et al, 2013), different original studies (Zhang et al, 2010;Liu et al, 2011;Xie et al, 2012;Li et al, 2013;Zeng et al, 2013) and different inclusion criteria Li et al, 2013). Furthermore, new emerging articles on this association need to be included for reevaluation.…”

“…To investigate this relationship, five metaanalyses articles have been published in the last five years (Zhang et al, 2010;Liu et al, 2011;Xie et al, 2012;Li et al, 2013;Zeng et al, 2013). But the conclusions are paradoxical because of data duplicates, data missing, different original studies and different inclusion criteria.…”

“…Among these, five papers (Zhang et al, 2010;Liu et al, 2011;Xie et al, 2012;Li et al, 2013;Zeng et al, 2013) which were meta-analysis papers, four studies which were conducted (Yu et al, 2003;Han et al, 2004;Long , 2004;Han et al, 2012) on the same population, four (Long et al, 2008;Ding et al, 2012;Jung et al, 2012) papers not providing adequate data for calculation of OR and 95% CI, and four Su et al, 2008;Guo et al, 2012;Bose et al, 2013) studies not in accordance with HWE were excluded. A flow diagram summarizing the process of study selection was illustrated in Figure 1.…”

An Updated Meta-analysis on the Association of X-Ray Repair Cross Complementing Group 1 Codon 399 Polymorphism with Hepatocellular Carcinoma Risk

“…Although, in recent year, several meta-analyses on XRCC1 Arg399Gln polymorphism related to HCC risk have been reported, conclusions drawn from them were not consistent. Four published meta-analyses failed to observe any positive association between XRCC1 Arg399Gln polymorphism and HCC risk Liu et al, 2011;Xie et al, 2012;Zeng et al, 2013). Two articles (Chen et al, 2011;Pan et al, 2013) reported that XRCC1 Arg399Gln polymorphism was associated with the susceptibility to HCC in total population, but several papers published before 2011 were not included in Chen et al's study; In Pan et al's paper, one overlapping paper was not excluded and Long et al's paper (Long et al, 2006) with controls being not in accordance with Hardy-Weinberg equilibrium (HWE) was mistakenly included in Pan et al's paper.…”