Dual-coil magnetomotive optical coherence tomography for contrast enhancement in liquids

Kim, Jongsik; Ahmad, Adeel; Boppart, Stephen A.

doi:10.1364/oe.21.007139

Cited by 12 publications

(11 citation statements)

References 20 publications

(38 reference statements)

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“…Since biological tissues are inherently conductive, this method makes possible a wide range of investigations using biocurrent and tissue conductivity to study not only biomechanical properties, but also electrophysiological properties. A related alternative, extensively investigated by the Boppart group, is the use of magnetic nanoparticles, incorporated into tissues placed in an external magnetic field, as internal transducers for magnetomotive vibration [125][126][127][128][129][130][131][132][133][134][135][136][137][138][139]. Thus, loading is highly localized, to individual or aggregations of nanoparticles, but distributed throughout the tissue, and dynamic, in the alternating-current magnetic field.…”

Section: Loading Methodsmentioning

confidence: 99%

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Larin

Sampson

2017

Biomed. Opt. Express

364

258

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Abstract:Optical coherence elastography (OCE), as the use of OCT to perform elastography has come to be known, began in 1998, around ten years after the rest of the field of elastography -the use of imaging to deduce mechanical properties of tissues. After a slow start, the maturation of OCT technology in the early to mid 2000s has underpinned a recent acceleration in the field. With more than 20 papers published in 2015, and more than 25 in 2016, OCE is growing fast, but still small compared to the companion fields of cell mechanics research methods, and medical elastography. In this review, we describe the early developments in OCE, and the factors that led to the current acceleration. Much of our attention is on the key recent advances, with a strong emphasis on future prospects, which are exceptionally bright.

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Section: Loading Methodsmentioning

confidence: 99%

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Larin

Sampson

2017

Biomed. Opt. Express

364

258

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“…It should be noted that there are a variety methods for performing MMOCT that are not necessarily subject to all of the discussion above, such as a two-coil system for MNP contrast in fluids [33], and the use of pulsed, rather than sinusoidal, B-fields [34]. Also, related platforms for imaging, including optical Doppler tomography (ODT), optical coherence elastography (OCE), and optical coherence microscopy (OCM) have been employed with magnetomotive contrast.…”

Section: Magnetomotive Oct: Theory and Practicementioning

confidence: 99%

“…To address this need, Kim et al (2013) developed the dual-coil MMOCT system displayed in Fig. 3 [33]. In this configuration, the coils are used to apply opposing forces in sequence, in order to initially displace then restore MIOs in solution.…”

Section: Magnetomotive Oct Experimentsmentioning

confidence: 99%

Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography

Oldenburg

Blackmon

Sierchio

2016

IEEE J. Select. Topics Quantum Electron.

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Optical coherence tomography (OCT) has gained widespread application for many biomedical applications, yet the traditional array of contrast agents used in incoherent imaging modalities do not provide contrast in OCT. Owing to the high biocompatibility of iron oxides and noble metals, magnetic and plasmonic nanoparticles, respectively, have been developed as OCT contrast agents to enable a range of biological and pre-clinical studies. Here we provide a review of these developments within the past decade, including an overview of the physical contrast mechanisms and classes of OCT system hardware addons needed for magnetic and plasmonic nanoparticle contrast. A comparison of the wide variety of nanoparticle systems is also presented, where the figures of merit depend strongly upon the choice of biological application.

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“…With new improvements in next-generation OCT technology, such as spectral and Fourier domain OCT, recent advances in dynamic OCE have been introduced that circumvent the need for traditional cross-correlation-based speckle tracking. 116 In dynamic OCE, acoustic radiative forces 117,118 or oscillating magnetic fields 119 are applied to drive mechanical perturbations and the local elasticity of tissue is assessed from the detected phase-resolved signals. 120 These methods, however, have not yet been demonstrated in arterial tissue, and further development is needed prior to intracoronary investigation to include simultaneous delivery of acoustic pulses, magnetic field excitation, or magnetic nanoparticles in vivo.…”

Section: Intravascular Optical Coherence Elastographymentioning

confidence: 99%

Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture

Nadkarni

2013

J. Biomed. Opt

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Abstract. During the pathogenesis of coronary atherosclerosis, from lesion initiation to rupture, arterial mechanical properties are altered by a number of cellular, molecular, and hemodynamic processes. There is growing recognition that mechanical factors may actively drive vascular cell signaling and regulate atherosclerosis disease progression. In advanced plaques, the mechanical properties of the atheroma influence stress distributions in the fibrous cap and mediate plaque rupture resulting in acute coronary events. This review paper explores current optical technologies that provide information on the mechanical properties of arterial tissue to advance our understanding of the mechanical factors involved in atherosclerosis development leading to plaque rupture. The optical approaches discussed include optical microrheology and traction force microscopy that probe the mechanical behavior of single cell and extracellular matrix components, and intravascular imaging modalities including laser speckle rheology, optical coherence elastography, and polarization-sensitive optical coherence tomography to measure the mechanical properties of advanced coronary lesions. Given the wealth of information that these techniques can provide, optical imaging modalities are poised to play an increasingly significant role in elucidating the mechanical aspects of coronary atherosclerosis in the future.

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Dual-coil magnetomotive optical coherence tomography for contrast enhancement in liquids

Cited by 12 publications

References 20 publications

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography

Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture

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