The “DGPPN-Cohort”: a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients

Anderson‐Schmidt, Heike; Adler, Lothar; Aly, Chadiga; Anghelescu, Ion; Bauer, Michael; Baumgärtner, Jessica; Becker, Joachim; Bianco, Roswitha; Becker, Thomas; Bitter, Cosima; Bönsch, Dominikus; Buckow, Karoline; Budde, Monika; Bührig, Martin; Deckert, Jürgen; Demiroglu, Sara Y.; Dietrich, Detlef E.; Dümpelmann, Michael; Engelhardt, Uta; Fallgatter, Andreas J.; Feldhaus, Daniel; Figge, Christian; Folkerts, Here; Franz, Michael; Gade, Katrin; Gäebel, Wolfgang; Grabe, Hans J.; Gruber, Oliver; Gullatz, V.; Gusky, Linda; Heilbronner, Urs; Helbing, Krister; Hegerl, Ulrich; Heinz, Andreas; Hensch, Tilman; Hiemke, Christoph; Jäger, Markus; Jahn-Brodmann, Anke; Juckel, Georg; Kandulski, Franz; Kaschka, Wolfgang P.; Kircher, Tilo; Köller, Manfred; Konrad, Carsten; Kornhuber, Johannes; Krause, Marina; Krug, Axel; Lee, Mahsa; Leweke, F. Markus; Lieb, Klaus; Mammes, Mechthild; Meyer‐Lindenberg, Andreas; Mühlbacher, Moritz; Müller, Matthias J.; Nieratschker, Vanessa; Nierste, Barbara; Ohle, Jacqueline; Pfennig, Andrea; Pieper, Marlenna; Quade, Matthias; Reich‐Erkelenz, Daniela; Reif, Andreas; Reitt, Markus; Reininghaus, Bernd; Reininghaus, Eva; Riemenschneider, Matthias; Rienhoff, Otto; Roser, Patrik; Rujescu, Dan; Schennach, Rebecca; Scherk, Harald; Schmauß, Max; Schneider, Frank; Schosser, Alexandra; Schott, Björn H.; Schwab, S.G.; Schwanke, J.; Skrowny, Daniela; Spitzer, Carsten; Stierl, Sebastian; Stöckel, Judith; Stübner, Susanne; Thiel, Andreas; Volz, Hans Peter; Hagen, Martin von; Walter, Henrik; Witt, Stephanie H.; Wobrock, Thomas; Zielasek, Jürgen; Zimmermann, Jörg; Zitzelsberger, Antje; Maier, Wolfgang; Falkai, Peter; Rietschel, Marcella; Schulze, Thomas G.

doi:10.1007/s00406-013-0401-8

Cited by 20 publications

(14 citation statements)

References 14 publications

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“…These centers are clinical collaborators of an ongoing study on genotype-phenotype relationships and the neurobiology of the longitudinal course of major psychiatric disorders (www.kfo241.de and www.PsyCourse.de). This study combines comprehensive longitudinal deep phenotyping, longitudinal sampling of various types of biomaterial, and state-of-the art proband management and biobanking, as well as advanced data protection, governed by stringent standard operating procedures for a multicenter study framework like ours (52)(53)(54)(55). Blood was collected in Pax gene tubes and incubated for 2 h at room temperature.…”

Section: Materials/subjects and Methodsmentioning

confidence: 99%

HDAC1 links early life stress to schizophrenia-like phenotypes

Bahari‐Javan

Varbanov

Halder

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Schizophrenia is a devastating disease that arises on the background of genetic predisposition and environmental risk factors, such as early life stress (ELS). In this study, we show that ELS-induced schizophrenia-like phenotypes in mice correlate with a widespread increase of histone-deacetylase 1 (Hdac1) expression that is linked to altered DNA methylation. Hdac1 overexpression in neurons of the medial prefrontal cortex, but not in the dorsal or ventral hippocampus, mimics schizophrenia-like phenotypes induced by ELS. Systemic administration of an HDAC inhibitor rescues the detrimental effects of ELS when applied after the manifestation of disease phenotypes. In addition to the hippocampus and prefrontal cortex, mice subjected to ELS exhibit increased Hdac1 expression in blood. Moreover, Hdac1 levels are increased in blood samples from patients with schizophrenia who had encountered ELS, compared with patients without ELS experience. Our data suggest that HDAC1 inhibition should be considered as a therapeutic approach to treat schizophrenia.

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Section: Materials/subjects and Methodsmentioning

confidence: 99%

HDAC1 links early life stress to schizophrenia-like phenotypes

Bahari‐Javan

Varbanov

Halder

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…The sample has been described elsewhere [16] and is part of the so-called 'DGPPN Cohort', a national collaboration initiative of the German Association for Psychiatry, Psychotherapy and Psychosomatics (DGPPN) to establish a large-scale cohort of psychiatric patients [24] . In short, the sample comprised 43 women and 57 men with a mean age of 39.8 years.…”

Section: Samplingmentioning

confidence: 99%

Psychopathological Course Typology in Schizophrenia Spectrum Disorders: A Heuristic Approach in a Sample of 100 Patients

Wigand

Lang²,

Becker³

et al. 2016

Psychopathology

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Background: Despite several previous attempts at subtyping schizophrenia, a typology that reflects neurobiological knowledge and reliably predicts course and outcome is lacking. We applied the system-specific concept of the Bern Psychopathology Scale (BPS) to generate a course typology based on three domains: language, affectivity, and motor behaviour. Sampling and Methods: A cohort of 100 patients with schizophrenia or schizoaffective disorders according to DSM-IV criteria underwent psychopathological assessment, and all their available medical records were retrospectively analysed on the basis of the BPS. Results: Overall, 39% of the patients showed dominant abnormalities in only one domain, 37% in two domains, and 24% in all three domains. The motor domain was affected in the majority of patients (76%), followed by affectivity (63%) and language (46%). Eighty-six percent of patients showed a bipolar course pattern in at least one domain. Conclusions: In a retrospective analysis of 100 patient records we described system-specific course patterns of schizophrenia by using a neurobiologically informed psychopathological assessment. The results showed a surprisingly high proportion of bipolar courses and a pattern of pure and mixed subtypes, which speaks for an overlap of domains with regards to psychopathological symptoms. A limitation of this heuristic and retrospective approach is that it was largely based on clinical judgement. Prospective studies with more rigorous threshold definitions are needed to clarify the neurobiological and clinical implications of the proposed reorganization of psychotic disorders.

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“…We recruited 100 inpatients (43 women and 57 men) at the Department of Psychiatry II, Ulm University, Germany, between August 2013 and November 2014 as part of the large-scale “DGPPN Cohort,” a national initiative of the German Association for Psychiatry, Psychotherapy and Psychosomatics (DGPPN) [17]. Consecutively admitted patients were asked to participate.…”

Section: Methodsmentioning

confidence: 99%

Psychosis Is Mutable over Time: A Longitudinal Psychopathology Study

et al. 2018

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Background: A neurobiologically informed, system-specific psychopathological approach has been suggested for use in schizophrenia. However, to our knowledge, such an approach has not been used to prospectively describe the course of schizophrenia. Sampling and Methods: We assessed psychopathology in a well-described sample of 100 patients with schizophrenia or schizoaffective disorder with the Bern Psychopathology Scale (BPS) at 6-month intervals for up to 18 months. The BPS groups symptoms into the 3 domains language, affectivity and motor behaviour; each domain is rated as being normal, inhibited or disinhibited. In addition, we collected qualitative psychopathological data in the form of case reports. Results: Forty-eight patients completed at least 2 assessments over the course of at least 1 year. Of these, 16 patients (33.3%) showed a bipolar course pattern (i.e., a switch from inhibited to disinhibited or vice versa) in 1 domain and 6 patients (12.5%) in more than 1 domain. Shifts from 1 dominant domain to another were seen frequently (n = 20, 41.7%), but shifts between 1 dominant domain and a combination of dominant domains were more common (n = 33, 68.8%). Conclusions: The course of schizophrenia is heterogeneous and shows frequent changes in psychopathology. This should be taken into account in the communication with patients and in the research on underlying illness mechanisms and treatment. A major limitation of this study is the small sample size.

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The “DGPPN-Cohort”: a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients

Cited by 20 publications

References 14 publications

HDAC1 links early life stress to schizophrenia-like phenotypes

HDAC1 links early life stress to schizophrenia-like phenotypes

Psychopathological Course Typology in Schizophrenia Spectrum Disorders: A Heuristic Approach in a Sample of 100 Patients

Psychosis Is Mutable over Time: A Longitudinal Psychopathology Study

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