The effect of homogenization method on the properties of carbamazepine microparticles prepared by spray congealing

Abstract

The aim of this study was to investigate the influence of ultrasound and high-shear mixing on the properties of microparticles obtained by spray congealing. Dispersions containing 10% carbamazepine and 90% carrier Gelucire® 50/13 (w/w) were prepared using magnetic stirring, high-shear mixing, or ultrasound. Each preparation was made using hot-melt mixing spray congealing to obtain the microparticles. All microparticles presented a spherical shape with high encapsulation efficiency (>99%). High-shear mixing and ultrasound promoted a decrease in the size of microparticles (D90) to 62.8 ± 4.1 μm and 64.9 ± 3.3 μm, respectively, while magnetic stirring produced microparticles with a size of 84.1 ± 1.4 µm. The use of ultrasound led to microparticles with increased moisture content as identified through sorption isotherm studies. In addition, rheograms showed distinct rheological behaviour among different dispersion preparations. Therefore, the technique used to prepare dispersions for spray congealing can affect specific characteristics of the microparticles and should be controlled during the preparation.

A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen

“…However, the sharp melting peak of IBU was not observed in the DSC curve of the corresponding physical mixtures either. This suggests that IBU had dissolved in the molten GB, similar to what has been reported in other studies 13,27,42,44 .…”

Spray congealing as innovative technique for enzyme encapsulation

“…A suspension or emulsion of a melted carrier and the compound that needs to be immobilized, is atomized through a nozzle followed by re‐solidifying based on temperature decrease (Scheme ). Thereby microparticles with a narrow size particle distribution and spherical shape are obtained …”

“…Thereby microparticles with a narrow size particle distribution and spherical shape are obtained. 7,8 Spray congealing presents an environmentally friendly encapsulation technique, due to no need for additional organic solvents, use of non-toxic matrices like lipids and only low-polluted exhaust gas. This innovative immobilization technique with low carrier costs allows easy up-scaling and presents a highly interesting immobilization method for industry.…”

“…This innovative immobilization technique with low carrier costs allows easy up-scaling and presents a highly interesting immobilization method for industry. 7,[9][10][11][12] Various studies based on spray congealing exist, whereby most of the applications are related to release of pharmaceutical products. For example, the working group of Passerini developed different systems for controlled release of pharmaceuticals, like verapamil hydrochloride, or for enhancing drug release.…”

Efeito da encapsulação de licopeno na sua estabilidade e biodisponibilidade

“…A produção de micropartículas por spray-chilling vem ganhando um grande interesse por utilizar-se de baixas temperaturas e por ser uma técnica ecológica, pois dispensa a utilização de solventes, tais como a água, durante a atomização. Em relação à terminologia da técnica de microencapsulação por spray-chilling, não há uma concordância na literatura, por isso muitas vezes os termos spray-cooling (GOUIN, 2004) e spray-congealing (ALBERTINI et al, 2008;ILIC et al, 2009;MARTINS et al, 2013) Zenebon et al, 2008), utilizando os fatores de correção de resposta do detector de ionização de chama e de conversão de ésteres metílicos de ácidos graxos para ácido graxo.…”