Increased IL-6 detection in adult and pediatric lymphoid tissue harboring Parvovirus B19

Polcz, Monica; Adamson, Laura; Lu, Xingrong; Chang, Myron; Fowler, Larry J.; Hobbs, Jacqueline A.

doi:10.1016/j.jcv.2013.02.022

Cited by 14 publications

(10 citation statements)

References 36 publications

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“…That study supported an earlier clinical observation in which B19 was associated with lung cancer in a Japanese patient [40]. Moreover, as mentioned in the introduction, parvovirus B19 was suspected to be a causative agent of other cancers and may induce chronic inflammatory processes in an infected tissue [19–24]. Similar mechanisms may play a role in HBoV infected tissues; future studies should thus focus on the inflammatory processes associated with HBoV.…”

Section: Discussionsupporting

confidence: 86%

“…Given that other parvoviruses are able to integrate into the host genome [18], and the first known pathogenic human parvovirus, parvovirus B19, is associated with several cancers, including lymphomas [19], testicular tumors [20], papillary and anaplastic thyroid carcinomas [21,22], and chronic inflammatory diseases such as Hashimoto’s thyroiditis [23], cardiomyopathy and myocarditis [24], a similar mechanism for HBoV-associated pathogenesis appears possible.…”

Section: Introductionmentioning

confidence: 99%

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The Human Bocavirus Is Associated with Some Lung and Colorectal Cancers and Persists in Solid Tumors

et al. 2013

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Human bocavirus is the second autonomous human parvovirus with assumed pathogenic potential. Other parvoviruses are known to persist and even integrate into the host genome, eventually contributing to the multi-step development of cancer. Human bocavirus also persists in an unknown percentage of clinically asymptomatic patients in addition to those with primary infection. The aim of the present study was to analyze the role of Human bocavirus in lung and colorectal cancers. Therefore, formalin-fixed, paraffin-embedded, archived tumor samples were screened for Human bocavirus DNA by PCR, Southern blotting, and sequencing. Positive tissues were further subjected to fluorescence in situ hybridization analysis to specifically detect human bocavirus DNA in the infected cells. In total, 11 of the 60 (18.3%) lung and 9 of the 44 (20.5%) colorectal tumors tested positive for human bocavirus DNA by PCR and were confirmed by sequencing and fluorescence in situ hybridization analysis. Thus, human bocavirus DNA is present in the nuclei of infected cells, in either single or multiple copies, and appears to form concatemers. The occurrence of these human bocavirus DNA structures supports the existence of the postulated σ- or rolling-hairpin replication mechanism. Moreover, the fluorescence in situ hybridization patterns inspired the hypothesis that human bocavirus DNA either persists as cccDNA or is integrated into the host genome. This finding suggests that this virus may indirectly contribute to the development of some colorectal and lung cancers, as do other DNA viruses, such as the human hepatitis B virus, or may play an active role in cancer by interacting with the host genome.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

The Human Bocavirus Is Associated with Some Lung and Colorectal Cancers and Persists in Solid Tumors

et al. 2013

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“…Other than the skin, the list of healthy and diseased tissues allegedly harbouring B19V DNA or VP2 protein includes, in alphabetical order, bone marrow, brain, colon, heart, kidney, liver, lung, lymphoid tissue, small intestine, stomach, synovium, testis and thyroid . This has led to claims of involvement of the virus in acute myocarditis and dilated cardiomyopathy; Kikuchi–Fujimoto disease; malignant lymphomas; nonocclusive gangrene of stomach and bowel; colon carcinoma; testicular neoplasia; and thyroid disorders . The initial enthusiasm in the cardiology literature has somewhat subsided, in view of the evidence for lifelong persistence of B19V DNA in the myocardium .…”

Section: Discussionmentioning

confidence: 99%

Detection of human parvovirus B19 DNA in 22% of 1815 cutaneous biopsies of a wide variety of dermatological conditions suggests viral persistence after primary infection and casts doubts on its pathogenic significance

et al. 2017

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“…Following staining, slides were scanned into the Aperio Scanscope CS system (Aperio Technologies, Vista, CA, USA) at a magnification of 20× and staining was quantified using the Aperio Imagescope software. The scanned slides were analyzed using the appropriate algorithms as described previously (14, 29, 30). The Aperio Imagescope software positive pixel counts for diaminobenzidine (DAB) staining in the color deconvolution algorithm was completed for HGF, pAKT, and pS6, and membrane IHC algorithm for c-Met quantification (14, 29, 30).…”

Section: Methodsmentioning

confidence: 99%

“…The scanned slides were analyzed using the appropriate algorithms as described previously (14, 29, 30). The Aperio Imagescope software positive pixel counts for diaminobenzidine (DAB) staining in the color deconvolution algorithm was completed for HGF, pAKT, and pS6, and membrane IHC algorithm for c-Met quantification (14, 29, 30). Aperio digital analysis of DAB allows for no subjective bias in quantification.…”

Section: Methodsmentioning

confidence: 99%

Weight Loss Reversed Obesity-Induced HGF/c-Met Pathway and Basal-Like Breast Cancer Progression

Sundaram

Essaid

et al. 2014

Front. Oncol.

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Epidemiologic studies demonstrate that obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). Using the C3(1)-TAg murine model of BBC, we previously demonstrated that mice displayed an early onset of tumors when fed obesogenic diets in the adult window of susceptibility. Obesity was also shown to elevate mammary gland expression and activation of hepatocyte growth factor (HGF)/c-Met compared to lean controls, a pro-tumorigenic pathway associated with BBC in patients. Epidemiologic studies estimate that weight loss could prevent a large proportion of BBC. We sought to investigate whether weight loss in adulthood prior to tumor onset would protect mice from accelerated tumorigenesis observed in obese mice. Using a life-long model of obesity, C3(1)-TAg mice were weaned onto and maintained on an obesogenic high-fat diet. Obese mice displayed significant elevations in tumor progression, but not latency or burden. Tumor progression was significantly reversed when obese mice were induced to lose weight by switching to a control low-fat diet prior to tumor onset compared to mice maintained on obesogenic diet. We investigated the HGF/c-Met pathway known to regulate tumorigenesis. Importantly, HGF/c-Met expression in normal mammary glands and c-Met in tumors was elevated with obesity and was significantly reversed with weight loss. Changes in tumor growth could not be explained by measures of HGF action including phospho-AKT or phospho-S6. Other mediators associated with oncogenesis such as hyperinsulinemia and a high leptin:adiponectin ratio were elevated by obesity and reduced with weight loss. In sum, weight loss significantly blunted the obesity-responsive pro-tumorigenic HGF/c-Met pathway and improved several metabolic risk factors associated with BBC, which together may have contributed to the dramatic reversal of obesity-driven tumor progression. Future research aims to evaluate the role of obesity and the HGF/c-Met pathway in basal-like breast cancer progression.

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Increased IL-6 detection in adult and pediatric lymphoid tissue harboring Parvovirus B19

Cited by 14 publications

References 36 publications

The Human Bocavirus Is Associated with Some Lung and Colorectal Cancers and Persists in Solid Tumors

The Human Bocavirus Is Associated with Some Lung and Colorectal Cancers and Persists in Solid Tumors

Detection of human parvovirus B19 DNA in 22% of 1815 cutaneous biopsies of a wide variety of dermatological conditions suggests viral persistence after primary infection and casts doubts on its pathogenic significance

Weight Loss Reversed Obesity-Induced HGF/c-Met Pathway and Basal-Like Breast Cancer Progression

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