Antiangiogenic activity and direct antitumor effect from a sulfated polysaccharide isolated from seaweed

Dore, Celina Maria Pinto Guerra; Alves, Monique Gabriela Chagas Faustino; Santos, Nednaldo Dantas dos; Cruz, Ana Katarina Menezes da; Câmara, Rafael Barros Gomes; Castro, Allisson Jonathan G.; Alves, Luciana G.; Nader, Helena B.; Leite, Edda Lisboa

doi:10.1016/j.mvr.2013.03.001

Cited by 47 publications

(26 citation statements)

References 28 publications

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“…Ocean posses several biological active compounds which are helpful for the discovery of novel molecules for the treatment of hormonal based disorders such as cancer, diabetes, arthritis etc., Ocean weeds has maximum nutritional value that can be used as dietary protein supplement for the treatment of protein malnutrition conditions (Aravindan et al, 2013;Guerra Dore et al, 2013). Sargassum longiotom (S. longiotom) is large brown seaweed of the division Phaeophyta.…”

Section: Introductionmentioning

confidence: 99%

Investigations on the anti-diabetic potential of novel marine seaweed <i>Sargassum longiotom</i> against alloxan-induced diabetes mellitus: A pilot study

Selvaraj

Sampathkumar

2014

Bangladesh J Pharmacol

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The present study evaluated the hypoglycemic effect of brown algae Sargassum longiotom in alloxan-induced diabetic rats. After the treatment with S. longiotom extract, there is a significant reduction (p<0.001) in blood glucose when compared with the diabetic control group. Moreover the ethanolic extract of S. longiotom significantly reduces (p<0.001) the levels of triglycerides, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol dose dependent manner. Alternatively, it increases the highdensity lipoprotein cholesterol level in the treated groups. The values of SGOT, SGPT and ALP have been significantly reduced (p<0.001) in the treated rats when compared to diabetic control. Thus the present study indicates that the ethanolic extract of seaweed S. longiotom posses very effective hypoglycemic and hypolipidemic effect on the alloxan induced diabetic rats compared to the reference drug glibenclamide. Article Info

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Section: Introductionmentioning

confidence: 99%

Investigations on the anti-diabetic potential of novel marine seaweed <i>Sargassum longiotom</i> against alloxan-induced diabetes mellitus: A pilot study

Selvaraj

Sampathkumar

2014

Bangladesh J Pharmacol

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“…The data demonstrated that K5-NS,OS had a potent suppressing effect on the growth of B16 cells in vitro. Sulfated polysaccharides can enhance their antitumor activity because of the introduction of sulfated groups in the polysaccharide, which results in a change in its physicochemical characterization and chain conformation [28]. K5-OS was a sulfated polysaccharide with sulfate at Oposition and K5-NS was sulfated at N-position in our study.…”

Section: Effect Of K5ps and Its Derivates On The Growth Of B16 Melanomentioning

confidence: 63%

Modulating the SDF-1/CXCL12-induced cancer cell growth and adhesion by sulfated K5 polysaccharides in vitro

Teng

Deng

et al. 2015

Biomedicine & Pharmacotherapy

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“…RT-PCR analysis confi rmed that the relative levels of VEGF transcript in HUVEC cells were decreased by brittle star extracted polysaccharide after 48 h. The anti-angiogenic potential of brittle star polysaccharide was also examined in vivo with CAM model and showed the dose dependent reduction of blood vessel numbers and branching patterns. There are many surveys relating to the anti-angiogenic effi cacy of certain natural polysaccharides (28).…”

Section: Discussionmentioning

confidence: 99%

Anti-Vasculogenic Activity of a Polysaccharide Derived from Brittle Star via Inhibition of VEGF, Paxillin and MMP-9

Baharara

Amini

Musavi

2017

Iran. J. Biotechnol.

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Background: Bioactive compounds such as terpenoids, chondroitin sulfate, and polysaccharides with added value can be found in prestine marine creatures. These compounds often do have highly valuable therapeutic applications such as being antioxidant, antitumorogenic, anti-infl ammatory and anti-angiogenic. For the latter, varieties of angiogenesis factors can suppress this issue within the bodily tissues. Objectives: The anti-angiogenic and anti-metastatic capacity of a polysaccharide derived from brittle star was investigated. Material and Methods:The anti-proliferative eff ect of derived polysaccharide on umbilical vein endothelial cells (HUVEC) was measured using MTT (dimethyl thiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay. The anti-angiogenic eff ect of the isolated polysaccharide was examined by Chorioallantoic membrane (CAM) assay. The transcriptional expression of VEGF (Vascular Endothelial Growth Factor) was evaluated by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). The anti-metastatic activity was investigated via scratch-wound healing assay. The levels of Paxillin and Matrix Metalloproteinase-9 (MMP-9) expression were analyzed by RT-PCR. Statistical analysis and mean comparisons (p< 0.05) were carried out by SPSS 16. Results: Our results elucidated that the brittle star isolated polysaccharide exerted a dose dependent cytotoxic eff ect on the HUVEC endothelial cells. The CAM assay exhibited potent anti-angiogenic activity in vivo. The RT-PCR analysis showed that the extracted polysaccharide (40, 60 μg.mL ) was administrated via down-regulation of paxillin and MMP-9 mRNA expression. Conclusions: Taken together, these results indicated that the polysaccharide extracted from brittle star was able to decrease the viability of the HUVEC cells, to suppress angiogenesis, and possibly act as a natural anti-angiogenic and anti-metastatic marine organic compound against angiogenesis related pathologies.

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Antiangiogenic activity and direct antitumor effect from a sulfated polysaccharide isolated from seaweed

Cited by 47 publications

References 28 publications

Investigations on the anti-diabetic potential of novel marine seaweed <i>Sargassum longiotom</i> against alloxan-induced diabetes mellitus: A pilot study

Investigations on the anti-diabetic potential of novel marine seaweed <i>Sargassum longiotom</i> against alloxan-induced diabetes mellitus: A pilot study

Modulating the SDF-1/CXCL12-induced cancer cell growth and adhesion by sulfated K5 polysaccharides in vitro

Anti-Vasculogenic Activity of a Polysaccharide Derived from Brittle Star via Inhibition of VEGF, Paxillin and MMP-9

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