2013
DOI: 10.1016/j.mvr.2013.03.001
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Antiangiogenic activity and direct antitumor effect from a sulfated polysaccharide isolated from seaweed

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Cited by 47 publications
(26 citation statements)
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“…Ocean posses several biological active compounds which are helpful for the discovery of novel molecules for the treatment of hormonal based disorders such as cancer, diabetes, arthritis etc., Ocean weeds has maximum nutritional value that can be used as dietary protein supplement for the treatment of protein malnutrition conditions (Aravindan et al, 2013;Guerra Dore et al, 2013). Sargassum longiotom (S. longiotom) is large brown seaweed of the division Phaeophyta.…”
Section: Introductionmentioning
confidence: 99%
“…Ocean posses several biological active compounds which are helpful for the discovery of novel molecules for the treatment of hormonal based disorders such as cancer, diabetes, arthritis etc., Ocean weeds has maximum nutritional value that can be used as dietary protein supplement for the treatment of protein malnutrition conditions (Aravindan et al, 2013;Guerra Dore et al, 2013). Sargassum longiotom (S. longiotom) is large brown seaweed of the division Phaeophyta.…”
Section: Introductionmentioning
confidence: 99%
“…The data demonstrated that K5-NS,OS had a potent suppressing effect on the growth of B16 cells in vitro. Sulfated polysaccharides can enhance their antitumor activity because of the introduction of sulfated groups in the polysaccharide, which results in a change in its physicochemical characterization and chain conformation [28]. K5-OS was a sulfated polysaccharide with sulfate at Oposition and K5-NS was sulfated at N-position in our study.…”
Section: Effect Of K5ps and Its Derivates On The Growth Of B16 Melanomentioning
confidence: 63%
“…RT-PCR analysis confi rmed that the relative levels of VEGF transcript in HUVEC cells were decreased by brittle star extracted polysaccharide after 48 h. The anti-angiogenic potential of brittle star polysaccharide was also examined in vivo with CAM model and showed the dose dependent reduction of blood vessel numbers and branching patterns. There are many surveys relating to the anti-angiogenic effi cacy of certain natural polysaccharides (28).…”
Section: Discussionmentioning
confidence: 99%