Circulating endothelial cell levels in psoriatic patients and their modification after an anti‐TNF‐alpha (Etanercept) treatment

Abstract

The elevated CECs level that we found in a sample of high selected psoriatic patients could be expression of endothelial damage. Lowering of CECs count after treatment with Etanercept support the hypothesis that an effective systemic therapy of psoriasis may also improve the endothelial function.

Psoriasis

“…Specific cell subsets present in the periphery, correlate well not only with disease status, but also with therapy response. Both pathogenic Th cell subsets (Th1, Th17, and Th22) and circulating endothelial cells, which can be used as an indirect measure of vascular injury, decrease after successful anti-TNF therapy, suggesting simultaneous improvement of disease activity and cardiovascular health during efficacious treatment (Kagami et al 2010;De Simone et al 2013). Interestingly, cutaneous lymphocyte-associated antigen expression on lymphocytes has been shown to negatively correlate to PASI score during anti-TNF therapy, allowing to predict responders and nonresponders within the first six weeks of treatment (Jokai et al 2013).…”