Features of Adenoma and Colonoscopy Associated With Recurrent Colorectal Neoplasia Based on a Large Community-Based Study

Heijningen, Else–Mariëtte B. van; Lansdorp–Vogelaar, Iris; Kuipers, Ernst J.; Dekker, Evelien; Lesterhuis, Wilco; Borg, Frank ter; Vecht, J. van der; Jonge, Vincent de; Spoelstra, P.; Engels, L.G.J.B.; Bolwerk, Clemens; Timmer, Robin; Kleibeuker, Jan H.; Koornstra, Jan J.; Ballegooijen, Marjolein van; Steyerberg, Ewout W.

doi:10.1053/j.gastro.2013.03.002

Cited by 94 publications

(127 citation statements)

References 32 publications

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“…mucosa and upper part of the submucosa) it can be safely removed by endoscopy preventing potential malignant transformation. Japanese and Western studies have shown that the endoscopic appearance of a polyp can predict invasion into the submucosa, which is associated with an increased risk of nodal metastases (2)(3)(4)(5)(6)(7) . Because of this predictive value, polyp morphology can be an important determinant of when to apply endoscopic therapy and when to refer for surgery.…”

Section: Introductionmentioning

confidence: 99%

Polyp Morphology: An Interobserver Evaluation for the Paris Classification Among International Experts

Doorn

Hazewinkel

East

et al. 2015

American Journal of Gastroenterology

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Our study is the first to validate the Paris classification for polyp morphology. We demonstrated only a moderate interobserver agreement among international Western experts for this classification system. Our data suggest that, in its current version, the use of this classification system in daily practice is questionable and it is unsuitable for comparative endoscopic research. We therefore suggest introduction of a simplification of the classification system.

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Section: Introductionmentioning

confidence: 99%

Polyp Morphology: An Interobserver Evaluation for the Paris Classification Among International Experts

Doorn

Hazewinkel

East

et al. 2015

American Journal of Gastroenterology

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“…Recently, van Heijningen et al (21) reported that the rate of AA recurrence was 7% and the rate of AR was 32% among their patients at the follow-up colonoscopy. In the Funen Adenoma Follow-up Study, Jørgensen et al (22) determined that the rate of AR was 35% in patients who had follow-up colonoscopy 2 years after the initial colonoscopy and 35.5% in those who had follow-up colonoscopy 4 years after the initial colonoscopy.…”

Section: Discussionmentioning

confidence: 99%

Role of baseline adenoma characteristics for adenoma recurrencein patients with high-risk adenoma

Solakoğlu¹,

Köseoğlu²,

Sarı³

et al. 2017

Turk J Med Sci

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IntroductionColorectal cancer (CRC), which is still associated with very high incidence and mortality rates, is the second most commonly diagnosed cancer in males and the third in females around the world (1-3). However, survival from CRC has seen an improvement over the past 30 years (4). Screening for CRC is recommended after 50 years of age for individuals at average risk (5-7). It is recognized that more than 95% of all CRCs develop from adenomas and it is accepted that the majority of CRC arise from the adenomacarcinoma sequence (8-11). The risk of an adenoma becoming malignant is greatest for advanced adenoma (AA) (adenoma with size ≥1 cm, villous elements, or highgrade dysplasia) (8,12). In the CRC screening guidelines patients with adenomas were stratified at their baseline colonoscopy into those at lower risk or increased risk for a subsequent advanced neoplasia (2,6,8). The low-risk group refers to patients with 1-2 tubular adenomas <10 mm in diameter, while the high-risk group refers to patients with tubular adenoma ≥10 mm, 3 or more adenomas, adenoma with villous elements, or high-grade dysplasia (6). The guideline for colonoscopy surveillance after screening and polypectomy recommends a 3-year surveillance interval for patients in the high-risk group and a 5-year surveillance interval for those in the low-risk group (6).According to a recent meta-analysis, it was hypothesized that the size of an adenoma is a more important determinant of adenoma recurrence (AR) than the villous component or high-grade dysplastic content (12). Although Martinez et al. (13) suggested that the size and number of removal adenomas were two important predictors of AR at follow-up colonoscopy, it is still not known exactly which adenoma feature is more important than the others for AR.The aim of the present study was to determine the baseline patient and colorectal adenoma characteristics that are risk factors for AR at 3-year surveillance colonoscopy in patients with high-risk adenoma.Background/aim: The present observational study aimed to determine the predictive value of 3-year recurrence adenoma characteristics at baseline conventional colonoscopy in patients with high-risk adenoma.Materials and methods: A total of 47 patients with high-risk adenoma at baseline colonoscopy were followed up and underwent a surveillance colonoscopy at 3 years. Correlations between adenoma recurrence and baseline adenoma characteristics (size, number, histological features, and location) were analyzed.Results: Among 135 patients with high-risk adenoma, 47 patients (35%) who underwent surveillance colonoscopy at 3 years following baseline colonoscopy were included in the study. In these 47 patients, at least one new adenoma was detected in 19 (40.4%) patients, and new advanced adenomas were detected in 5 (10.6%) patients during the surveillance colonoscopy. No significant difference was found in patients who had adenoma recurrence versus those who did not in terms of size of adenomas (P = 0.143), number of adenomas (P = 0.562), histologic...

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“…The study was approved by the institutional research Ethics Committee of Shandong Tumor Hospital, and written informed consent was obtained from each subject. Colorectal adenomas were defined in accordance with published criteria [31,32], based on at least one of the following characteristics: (1) polypoid lesions ≥10 mm; (2) microvilli structure > 25% in villous or mixed adenoma; or (3) high-grade dysplasia. In view of the effects of age and blood-glucose levels on lipid levels, we chose patients who were 18-70 years of age, with fasting glucose levels < 7 mmol/L.…”

Section: Subjectsmentioning

confidence: 99%

Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma

Wang

Zhang

et al. 2018

Dig Dis

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Fibroblast growth factor 19 (FGF19) promotes tumor growth in various types of cancer, but its function has not been investigated in the context of colorectal adenoma. Here, we report that FGF19 expression was greater in colorectal adenoma than in normal tissues, as measured by an enzyme-linked immunosorbent assay, quantitative reverse-transcription PCR and immunohistochemistry. FGF19 expression was also elevated in a subset of human colon cancer cell lines. Moreover, FGF receptor 4 (FGFR4), the cognate receptor for FGF19, was upregulated in colorectal adenoma tissues. Lipid levels and body mass index values strongly correlated with FGF19 and FGFR4 levels in patients with colon adenomas. These observations indicate that the FGF19/FGFR4 pathway may be involved in the development of neoplasia, and that FGF19 may be a valuable diagnostic marker for the identification of patients with colorectal adenomas.

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Features of Adenoma and Colonoscopy Associated With Recurrent Colorectal Neoplasia Based on a Large Community-Based Study

Cited by 94 publications

References 32 publications

Polyp Morphology: An Interobserver Evaluation for the Paris Classification Among International Experts

Polyp Morphology: An Interobserver Evaluation for the Paris Classification Among International Experts

Role of baseline adenoma characteristics for adenoma recurrencein patients with high-risk adenoma

Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma

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