Synergistic interaction of ferulic acid with commercial hypoglycemic drugs in streptozotocin induced diabetic rats

Prabhakar, Pranav Kumar; Prasad, Ram; Ali, Shakir; Doble, Mukesh

doi:10.1016/j.phymed.2012.12.004

Cited by 103 publications

(62 citation statements)

References 32 publications

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“…Oral treatment of FA (10 and 50 mg/kg BW) displayed antioxidant activity and inhibited lipid peroxidation markers in the serum, pancreas, liver, and kidney of STZ‐induced diabetic rats (Roy et al ., ). In a subsequent study, administration of FA (40 and 10 mg/kg BW for 3 weeks) to STZ‐induced diabetic rats reduced hyperglycemia, lipid profile, urea, creatinine, serum glutamic pyruvic transaminases and serum glutamic oxaloacetate transaminases, and preserve islet mass (Prabhakar et al ., ). HFD (17%) supplemented with FA (0.5%) has been shown to lead to higher insulin, glycogen, and glucokinase and lower blood glucose level and G6Pase and phosphoenolpyruvate carboxykinase activities in C57BL/6N mice (Son et al ., ).…”

Section: Phenolic Acids and Diabetes Mellitus: Overview Of Potential mentioning

confidence: 97%

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

2015

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Diabetes mellitus (DM) has become a major public health threat across the globe. Current antidiabetic therapies are based on synthetic drugs that very often have side effects. It has been widely acknowledged that diet plays an important role in the management of diabetes. Phenolic acids are widely found in daily foods such as fruits, vegetables, cereals, legumes, and wine and they provide biological, medicinal, and health properties. Simple phenolic acids have been shown to increase glucose uptake and glycogen synthesis, improve glucose and lipid profiles of certain diseases (obesity, cardiovascular diseases, DM, and its complication). The current review is an attempt to list out the antidiabetic effects of simple phenolic acids from medicinal plants and botanical foods.

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Section: Phenolic Acids and Diabetes Mellitus: Overview Of Potential mentioning

confidence: 97%

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

2015

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“…Hyperglycemia in diabetes may be related to numerous physiological events, such as decreased glucose in cells, reduced glucose utilization by various tissues, and increased hepatic production of glucose (gluconeogenesis) (Prabhakar et al, 2013). Complications experienced by patients with diabetes are often related to chronic hyperglycemia, including retinopathy, peripheral vascular disease, renal failure, neuropathy, and cardiovascular diseases that cause both morbidity and premature mortality (Hirany et al, 2000;Piaulino et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Schneider

Sachett

Schönell

et al. 2015

Revista Brasileira de Farmacognosia

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a b s t r a c tSolidago chilensis Meyen, Asteraceae, is traditionally used to treat inflammation. However, phytochemical and pharmacology investigations are lacking. This study evaluated the hypoglycemic and hypolipidemic effects of hydroalcoholic extract from S. chilensis aerial parts in rats. In oral glucose tolerance tests the rats received saline (0.5 ml/100 g) in control group (C), hydroalcoholic extract (125, 250 or 500 mg/kg p.o.; n = 6) or glibenclamide (10 mg/kg p.o.; n = 6). After 30 min, glucose (4 g/kg) was administered. Rats treated with hydroalcoholic extract 500 demonstrated decreased glucose levels at 180 min (−22.1%), when compared with group C, similar to glibenclamide. Moreover, treatment with hydroalcoholic extract 500 significantly increased the glycogen content in the liver and soleus muscle, and hydroalcoholic extract 250 specifically inhibited the enzyme maltase when compared with group C. Furthermore, all hyperglycemic rats treated with hydroalcoholic extract (125, 250 and 500) exhibited an accentuated decrease in total cholesterol levels (−36.8%, −36.7% and −41.3%, respectively). Our results suggest that hypoglycemic and hypolipidemic effects of hydroalcoholic extract could be associated with increased production and release of insulin as well as with insulinotropic and antioxidant effects.

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“…In rats induced with diabetes, FA significantly improved blood glucose levels and oxidative status in the pancreatic tissues [82], to a similar extent as other oral anti-diabetic drugs such as metformin and thiozolidinediones (TDZs) [83]. In leptin deficient db/ db mice, FA increased plasma insulin, lowered blood glucose, increased hepatic glycogen synthesis and the upregulated the activity of the glucoceogenesis gene glucokinase [84].…”

Section: Ferulic Acidmentioning

confidence: 72%

The Gut Microflora and its Metabolites Regulate the Molecular Crosstalk between Diabetes and Neurodegeneration

Lomis¹

2015

J Diabetes Metab

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The gut microflora is a community of trillions of bacterial cells synergistically inhabiting the human gastrointestinal tract. These microbes contact everything that is consumed and release regulatory factors that affect host energy homeostasis, lipid and carbohydrate metabolism, activation of immune cells, oxidative state, epithelial cell wall integrity and even neurological signals. The gut microflora is essentially an independent organ supporting human health where imbalances in the gut community populations (dysbiosis) manifest in disease. Diabetes and neurodegenerative disorders such as Alzheimer's and Parkinson's disease share a similar molecular pathology rooted in gut microflora activity. Both of these conditions are associated with a dysbiosis characterized by low species diversity, a higher proportion of pathobionts at the expense of symbionts, an abundance of proinflammatory microbes and fewer butyrate-producing strains. Many of these factors can be ameliorated with Lactobacillus spp. and Bifidobacterium spp. probiotic treatment aimed to reestablish healthy gut microflora diversity. Indeed, certain commensal and pathogenic strains promote chronic low-grade inflammation that stresses cellular infrastructure eventually leading to apoptosis in both the pancreas and the brain. Also, lack of some beneficial fermentation products such as butyrate and ferulic acid initiates a cascade of events disrupting metabolic homeostasis. Finally, signaling initiated by the microflora and its metabolites has been shown to disrupt the delicate intracellular balance of PI3K/Akt/mTOR signaling, which fundamentally regulates events leading up to diabetes and neurodegenerative disease pathogenesis. The following review investigates the relationship between the manifestation and molecular signaling of diabetes and neurodegenerative disorders and how the balance of gut microflora populations is critical to both prevent and possibly treat these diseases.

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Synergistic interaction of ferulic acid with commercial hypoglycemic drugs in streptozotocin induced diabetic rats

Cited by 103 publications

References 32 publications

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

The Gut Microflora and its Metabolites Regulate the Molecular Crosstalk between Diabetes and Neurodegeneration

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