Racial differences in HbA1c: A cross-sectional analysis of a Brazilian public primary care population

Miranda, Verônica Alcoforado de; Filho, Rubens Antunes da Cruz; Oliveira, Thiago; Moscavitch, Samuel Datum; Kang, Hye Chung; Chagas, Soraya V. Miranda; Costa, Dayana Bastos; Araújo, Denizar Vianna; Rosa, Maria Luiza Garcia

doi:10.1016/j.pcd.2013.01.007

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…Two studies with moderate quality presented insufficient data for criteria selection, study design and statistical analysis. The authors did not describe mean and SD for HbA1c [ 36 , 37 ], therefore it was necessary to contact them for that information. In addition, one of the works was a symposium poster presentation, without enough data in the abstract.…”

Section: Resultsmentioning

confidence: 99%

“…The subgroup comparing Black and White persons included a large number of individuals and the majority of the studies presented good quality. It consisted of African Americans, British African Caribbeans and Black Brazilians [ 19 , 22 , 24 , 25 , 36 , 37 , 40 ]. The five studies in the subgroup of Asians and Whites were carried out in the United Kingdom and included individuals of South Asian origin, mainly from India and Pakistan [ 20 , 34 , 35 , 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies were included in the meta-analysis for Blacks and Whites [ 19 , 22 , 24 , 25 , 36 , 37 , 40 ], totalling 27,576 subjects in this subgroup. Blacks had significantly higher HbA1c values than Whites.…”

Section: Resultsmentioning

confidence: 99%

“…When excluding the studies by Selvin et al [ 24 ] and by Carson et al [ 40 ] together there was no evidence of heterogeneity among studies (I 2 = 0%, p for heterogeneity = 0.64). We also investigated the effect of HbA1c methodology in the heterogeneity by performing an analysis excluding the study by Miranda et al [ 36 ], which was the only study that used immunoassay method. There was no change in the heterogeneity, although we observed a little increase in the difference of HbA1c values between Blacks and Whites (0.30% [3.3 mmol/mol; 95% CI 0.28 to 0.33 (3.1 to 3.6), p <0.001; I 2 = 92%, p for heterogeneity <0.001) when only studies that measured HbA1c by HPLC were considered.…”

Section: Resultsmentioning

confidence: 99%

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Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis

et al. 2017

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Aims/HypothesisDisparities in HbA1c levels have been observed among ethnic groups. Most studies were performed in patients with diabetes mellitus (DM), which may interfere with results due to the high variability of glucose levels. We conducted a systematic review and meta-analysis to investigate the effect of ethnicity on HbA1c levels in individuals without DM.MethodsThis is a systematic review with meta-analysis. We searched MEDLINE and EMBASE up to September 2016. Studies published after 1996, performed in adults without DM, reporting HbA1c results measured by certified/standardized methods were included. A random effects model was used and the effect size was presented as weighted HbA1c mean difference (95% CI) between different ethnicities as compared to White ethnicity.ResultsTwelve studies met the inclusion criteria, totalling data from 49,238 individuals. There were significant differences between HbA1c levels in Blacks [0.26% (2.8 mmol/mol); 95% CI 0.18 to 0.33 (2.0 to 3.6), p <0.001; I2 = 90%, p <0.001], Asians [0.24% (2.6 mmol/mol); 95% CI 0.16 to 0.33 (1.7 to 3.6), p <0.001; I2 = 80%, p = 0.0006] and Latinos [0.08% (0.9 mmol/mol); IC 95% 0.06 to 0.10 (0.7 to 1.1); p <0.001; I2 = 0%; p = 0.72] when compared to Whites.Conclusions/InterpretationThis meta-analysis shows that, in individuals without DM, HbA1c values are higher in Blacks, Asians, and Latinos when compared to White persons. Although small, these differences might have impact on the use of a sole HbA1c point to diagnose DM in all ethnic populations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis

et al. 2017

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“…Of the 19 chosen studies, nine [10][11][12][13][14][15][16][17][18] belong to the subtheme regarding general epidemiological aspects of Afro-Brazilian and ten [19][20][21][22][23][24][25][26][27][28] were more focused on Afro-Brazilian women's health.…”

Section: Results (Review)mentioning

confidence: 99%

Health panorama of the Afro-Brazilian population: a systematic review

Gonçalves

Sales

Vasconcelos

et al. 2021

BJCR

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In the present study, we sought to identify the current health panorama of the Afro-Brazilian population in the period from 2007 to 2021, based on a systematic review study. The nineteen selected studies allowed the creation of two thematic groups: Epidemiological aspects of pathologies in the afro-brazilian people and Health epidemiological aspects of the afro-brazilian women. We identified that some common chronic pathologies are Metabolic Syndrome (Hypertension, DM 2, Obesity) and Chronic Renal Insufficiency; infectocontagious pathologies like HIV/AIDS, tooth decay and Chagas disease; and mental disorders. In addition, smoking during pregnancy and anemia seem to be more prevalent in black women.

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Issues in Defining the Burden of Prediabetes Globally

2018

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Our review notes that the concept of prediabetes is increasingly recognized worldwide, but against a background of non-uniform definition and diagnostic criteria. This results in widely varying burden estimation. Current evidence shows a variety of prediabetes phenotypes. This reflects biological and diagnostic heterogeneity, resulting from the use of different tests (glucose or HbA) and thresholds to define prediabetes. The biological and diagnostic variabilities have implications for the characterization of the burden of prediabetes, natural history, prognosis, screening, implementation of lifestyle or drug interventions to mitigate related health risks, and monitoring of the effects of such interventions.

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Racial differences in HbA1c: A cross-sectional analysis of a Brazilian public primary care population

Cited by 9 publications

References 22 publications

Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis

Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis

Health panorama of the Afro-Brazilian population: a systematic review

Issues in Defining the Burden of Prediabetes Globally

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