Using susceptibility-weighted images to quantify iron deposition differences in amnestic mild cognitive impairment and Alzheimer′s disease

Wang, Dan; Zhu, Dan; Wei, Xiaoer; Li, Yuehua; Li, Wenbin

doi:10.4103/0028-3886.107924

Cited by 14 publications

(8 citation statements)

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“…Other literature reported similar iron increases with age in the putamen, globus pallidus, and caudate nucleus (Ward et al, 2014). Further studies on iron deposition in AD, MCI, and NC also revealed significant differences in the caudate nucleus and putamen (Wang et al, 2013). (3) From the gene expression frequency analysis, our study observed that the top three genes presented in the identified AD-predictive regions are CLU, MEF2C, and MAPT.…”

Section: Discussionsupporting

confidence: 61%

Characterization of Brain Iron Deposition Pattern and Its Association With Genetic Risk Factor in Alzheimer’s Disease Using Susceptibility-Weighted Imaging

You

Wang

et al. 2021

Front. Hum. Neurosci.

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The presence of iron is an important factor for normal brain functions, whereas excessive deposition of iron may impair normal cognitive function in the brain and lead to Alzheimer’s disease (AD). MRI has been widely applied to characterize brain structural and functional changes caused by AD. However, the effectiveness of using susceptibility-weighted imaging (SWI) for the analysis of brain iron deposition is still unclear, especially within the context of early AD diagnosis. Thus, in this study, we aim to explore the relationship between brain iron deposition measured by SWI with the progression of AD using various feature selection and classification methods. The proposed model was evaluated on a 69-subject SWI imaging dataset consisting of 24 AD patients, 21 mild cognitive impairment patients, and 24 normal controls. The identified AD progression-related regions were then compared with the regions reported from previous genetic association studies, and we observed considerable overlap between these two. Further, we have identified a new potential AD-related gene (MEF2C) closely related to the interaction between iron deposition and AD progression in the brain.

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Section: Discussionsupporting

confidence: 61%

Characterization of Brain Iron Deposition Pattern and Its Association With Genetic Risk Factor in Alzheimer’s Disease Using Susceptibility-Weighted Imaging

You

Wang

et al. 2021

Front. Hum. Neurosci.

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“…Several studies using T 2 * mapping and susceptibility weighted imaging (SWI) found increased iron content in brain gray matter including the hippocampus, frontal and parietal regions in AD patients (Wang et al, 2013;van Rooden et al, 2014). However, conventional gradient echo (GRE) imaging approaches are affected by blooming artifacts and cannot be easily quantified.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility and Volume Measures of the Mammillary Bodies Between Mild Cognitively Impaired Patients and Healthy Controls

Jin

Sethi

et al. 2020

Front. Neurosci.

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Purpose: To investigate the baseline values and differences for susceptibility and volume of the mammillary bodies between mild cognitively impaired (MCI) patients and healthy controls (HCs), and further explore their differences in relation to gender, MCI subtypes and apolipoprotein E (APOE) genotypes. Methods: T1-weighted and multi-echo gradient echo imaging sequences were acquired on a 3T MR scanner to evaluate the T1W based volume and susceptibility differences in the mammillary body for 47 MCI and 47 HCs. T-tests were performed to compare volume and susceptibility between groups, and right and left hemispheres. Correlation analysis was used to relate the volume and mean susceptibility as a function of age in MCI and HC groups separately, and to investigate the relationship of susceptibility with the neuro-psychological scales in the MCI group. Results: Susceptibility was found to be elevated within the right mammillary body in MCI patients compared to HCs (p < 0.05). There were no differences for the mammillary body volumes between the MCI and HC groups, although there was a reduction in volume with age for the MCI group (p = 0.007). Women showed decreased mammillary body volume compared to men in the HC group (p = 0.004). No significant differences were found in relation to MCI subtypes and APOE genotypes. No significant correlations were observed between mammillary body susceptibility with neuro-psychological scales. Conclusion: This work provides a quantitative baseline for both the volume and susceptibility of the mammillary body which can be used for future studies of cognitive impairment patients underlying the pathology of the Papez circuit.

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“…3 ’ 4 ’ 10 Wang et al identified increased iron content in the HP, head of CAU, lenticular nucleus and thalamus in amnestic Mild Cognitive Impairment and AD compared to controls. Further, Zhou et al demonstrated that SWI phase values of bilateral HP, GP, CAU, SN, and PUT were significantly different between AD and controls, which had a higher correlation coefficient with MMSE scores.…”

Section: Discussionmentioning

confidence: 99%

“…9 Recently, there has been an increasing interest in vivo quantitative estimation of non-heme iron in the pathophysiology of AD. 10,11 Postmortem studies indicate neurodegeneration with brain iron deposition in FTD-ALS 12 , and Pick disease. 13 A recent study in the post-mortem brains suggested that iron-impaired homeostasis possibly plays a crucial role in the pathogenesis of frontotemporal lobar degeneration (FTLD).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Iron Deposition in the Brain in Frontotemporal Dementia and Its Correlation with Behavioral Traits

Sheelakumari¹,

Kesavadas

Varghese³

et al. 2017

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Brain iron deposition has been implicated as a major culprit in the pathophysiology of neurodegeneration. However, the quantitative assessment of iron in behavioral variant frontotemporal dementia and primary progressive aphasia brains has not been performed, to our knowledge. The aim of our study was to investigate the characteristic iron levels in the frontotemporal dementia subtypes using susceptibility-weighted imaging and report its association with behavioral profiles.

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Using susceptibility-weighted images to quantify iron deposition differences in amnestic mild cognitive impairment and Alzheimer′s disease

Cited by 14 publications

References 0 publications

Characterization of Brain Iron Deposition Pattern and Its Association With Genetic Risk Factor in Alzheimer’s Disease Using Susceptibility-Weighted Imaging

Characterization of Brain Iron Deposition Pattern and Its Association With Genetic Risk Factor in Alzheimer’s Disease Using Susceptibility-Weighted Imaging

Susceptibility and Volume Measures of the Mammillary Bodies Between Mild Cognitively Impaired Patients and Healthy Controls

Assessment of Iron Deposition in the Brain in Frontotemporal Dementia and Its Correlation with Behavioral Traits

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