Vitamin D insufficiency is associated with challenge-proven food allergy in infants

Allen, Katrina J.; Koplin, Jennifer J.; Ponsonby, Anne–Louise; Gurrin, Lyle C.; Wake, Melissa; Vuillermin, Peter; Martin, Pamela E.; Matheson, Melanie C.; Lowe, Adrian J.; Robinson, Marnie; Tey, Dean; Osborne, Nicholas J.; Dang, Thanh; Tan, Hern‐Tze Tina; Thiele, Leone; Anderson, Deborah J.; Czech, H; Sanjeevan, Jeeva; Zurzolo, G.; Dwyer, Terence; Tang, Mimi L.K.; Hill, David; Dharmage, Shyamali C.

doi:10.1016/j.jaci.2013.01.017

Cited by 239 publications

(201 citation statements)

References 30 publications

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“…Since then, a considerable number of studies had been conducted linking vitamin D deficiency with autoimmune diseases and allergic disorders (Munger et al 2006;Frieri & Valluri 2011;Allen et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis

Dadacı

Borazan

Kiyici

et al. 2014

Acta Ophthalmologica

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ABSTRACT.Purpose: To evaluate plasma 25-hydroxyvitamin D and serum total immunoglobulin E (IgE) levels in patients with seasonal allergic conjunctivitis (SAC).Methods: This observational case-control study involved 49 patients with SAC without any other ocular and systemic diseases, and 44 consecutive, age-and sexmatched healthy subjects. Plasma 25-hydroxyvitamin D and serum total IgE levels of all subjects were quantified with electrochemiluminescence technique. Results were compared between the groups, and p values of <0.05 were considered as statistically significant. Results: No significant differences were found between the groups with respect to age (p = 0.41) and sex (p = 0.98). Plasma vitamin D levels of the subjects with SAC (median 8.03 ng/ml, range 3.00-17.97 ng/ml) were significantly lower than the control group (median 10.52 ng/ml, range 3.30-25.92 ng/ml) (p = 0.007). Serum total IgE levels of patients with SAC (median 48.65 IU/ml, range 1.77-812.00 IU/ml) were significantly higher when compared to the control group (median 32.49 IU/ml, range 0.14-104.60 IU/ml) (p = 0.003). Conclusions: We found lower plasma vitamin D levels and higher serum total IgE levels in patients with SAC.

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Section: Discussionmentioning

confidence: 99%

Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis

Dadacı

Borazan

Kiyici

et al. 2014

Acta Ophthalmologica

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“…A randomized controlled trial (n = 180) found that vitamin D supplementation during late pregnancy had no effect on the occurrence of wheezing, atopy, eczema or food allergy in the child by the age of 3 years [12]. Cross-sectional studies on children have either reported inverse associations with 25-OHD serum levels and atopic dermatitis [13] or food allergy [14], or no association [15]. …”

Section: Introductionmentioning

confidence: 99%

Serum 25-Hydroxyvitamin D in Early Childhood Is Nonlinearly Associated with Allergy

Savilahti¹,

Mäkitie²,

Kukkonen³

et al. 2016

Int Arch Allergy Immunol

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Background: Vitamin D has several immunological functions. Data on the relation of vitamin D status and allergy are controversial. Methods: We investigated the association between serum concentrations of 25-hydroxyvitamin D (25-OHD) and allergy in childhood. The study population (n = 819) was part of a randomized, double-blind, placebo-controlled trial where the mothers of offspring with a high risk for allergy received a mixture of probiotics (or placebo) for the last 4 weeks of pregnancy, and the child received this from birth to 6 months. Study subjects were followed for the emergence of sensitization and allergic symptoms for a period of 5 years, with medical examinations at the ages of 3 and 6 months, 2 and 5 years and also in the event of allergic symptoms. Levels of 25-OHD were measured in umbilical cord blood (UCB) samples (n = 724) and serum samples drawn at the age of 2 years (n = 369); the data were categorized into tertiles (T1-T3) and quartiles (Q1-Q4). The relation between 25-OHD levels and sensitization and allergy was analyzed with multivariable logistic regression analysis. Results: 25-OHD levels in T2 in UCB were associated with a higher risk for sensitization by the age of 2 years and allergic disorders by the age of 5 years. In the serum samples, at the age of 2 years, 25-OHD levels in Q3 were associated with a higher risk of sensitization and IgE-mediated allergies by the age of 5 years. Conclusions: The 25-OHD levels in early childhood are associated with the emergence of allergy, but the association appears to be nonlinear.

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“…137,138,139,140 Omega 3 El suplemento en el embarazo y la LM requiere mayor evidencia. 141 Cesárea Potenciaría el desarrollo de AA en niños predispuestos, por desregular la microbiota.…”

Section: Tabla 12 Medidas Preventivas Aspectos Relevantesunclassified

Alergia alimentaria en pediatría: recomendaciones para su diagnóstico y tratamiento. Texto completo

Alergia¹

2018

Arch Argent Pediatr

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Vitamin D insufficiency is associated with challenge-proven food allergy in infants

Abstract: These results provide the first direct evidence that vitamin D sufficiency may be an important protective factor for food allergy in the first year of life.

Cited by 239 publications

References 30 publications

Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis

Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis

Serum 25-Hydroxyvitamin D in Early Childhood Is Nonlinearly Associated with Allergy

Alergia alimentaria en pediatría: recomendaciones para su diagnóstico y tratamiento. Texto completo

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