Reduction in vasovagal reaction rate in young first‐time blood donors by collecting 350 <scp>mL</scp> rather than 450 <scp>mL</scp>

Wong, H. K.; Lee, C.K.; Leung, Jennifer; Lee, I.Y.; Lin, Chang-Le

doi:10.1111/trf.12134

Cited by 9 publications

(7 citation statements)

References 8 publications

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“…Two blood centers evaluated whether 450- or 500-ml whole-blood units had different vasovagal reaction rates in their general donor population and did not find a difference [26,27], but these studies did not evaluate a high-risk population. A recent study from Hong Kong [28] analyzed the vasovagal reaction rate in 38,436, first-time, 16- to 18-year-old whole-blood donors. Donors weighing more than 50 kg could opt for a 350- or 450-ml unit.…”

Section: Vasovagal Reactions - New Findings On Risk Factorsmentioning

confidence: 99%

Management of Young Blood Donors

Newman¹

2014

Transfus Med Hemother

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The emphasis on high-school blood drives and acceptance of 16-year-old blood donors led to more research on physiologic and psychological ways to decrease vasovagal reaction rates in young blood donors and to increase donor retention. Research on how to accomplish this has been advantageous for the blood collection industry and blood donors. This review discussed the current situation and what can be done psychologically, physiologically, and via process improvements to decrease vasovagal reaction rates and increase donor retention. The donation process can be significantly improved. Future interventions may include more dietary salt, a shorter muscle tension program to make it more feasible, recommendations for post-donation muscle tension / squatting / laying down for lightheadedness, more donor education by the staff at the collection site, more staff attention to donors with fear or higher risk for a vasovagal reaction (e.g. estimated blood volume near 3.5 l, first-time donor), and a more focused donation process to ensure a pleasant and safer procedure.

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Section: Vasovagal Reactions - New Findings On Risk Factorsmentioning

confidence: 99%

Management of Young Blood Donors

Newman¹

2014

Transfus Med Hemother

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“…It is important differentiate VVR from hypoglycemia. VVR is a rare complication of ALSS treatment and is more frequently associated with spine procedures [ 14 ], blood donation [ 15 ], cerebral angiography via femoral catheterization [ 11 ], and percutaneous coronary intervention [ 16 ]. In the general blood donor population, the VVR rate was reported to be 1.4%.…”

Section: Discussionmentioning

confidence: 99%

Characterization of an Artificial Liver Support System-Related Vasovagal Reaction

Xie

Zhang

et al. 2020

BioMed Research International

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Objective. An artificial liver support system (ALSS) is an effective therapy for patients with severe liver injury. A vasovagal reaction (VVR) is a common complication in various treatment settings but has not been reported previously in ALSS. Methods. This study retrospectively evaluated patients who suffered an ALSS-related VRR between January 2018 and June 2019. We collected data from VVR episodes including onset time, duration, changes in heart rate (HR) and blood pressure (BP), and drug treatment. Results. Among 637 patients who underwent ALSS treatment, 18 were included in the study. The incidence of VVR was approximately 2.82%. These patients were characterized by a rapid decrease in BP or HR with associated symptoms such as chest distress, nausea, and vomiting. The majority of patients (78%) suffered a VVR during their first ALSS treatment. Sixteen patients (89%) had associated symptoms after treatment began. Sixteen patients (89%) received human albumin or Ringer’s solution. Atropine was used in 11 patients (61%). The symptoms were relieved within 20 min in 15 patients and over 20 min in 3 patients. Conclusions. A VVR is a rare complication in patients with severe liver injury undergoing ALSS treatment. Low BP and HR are the main characteristics of a VVR.

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“…With the previously used procedure for IQC acquisition in our laboratory, four employees (normal ‘volunteers’) would undergo about 252 blood donations with a minimum blood volume of 5040 mL yearly. By comparison, one single unit of blood taken during a whole blood donation in blood banks is about 450 mL . That implies that yearly about 11 whole blood donations (450 mL × 11.2 = 5040 mL) from altogether four staff members would be performed in the laboratory.…”

Section: Discussionmentioning

confidence: 99%

Implementation of buffy‐coat‐derived pooled platelet concentrates for internal quality control of light transmission aggregometry: a proof of concept study

Prüller

Rosskopf

Mangge

et al. 2017

Journal of Thrombosis and Haemostasis

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Background Standardized commercially available control material for internal quality control (IQC) of light transmission aggregometry (LTA) is still lacking. Moreover, the availability of normal blood donors to provide fresh platelets is difficult in small laboratories, where 'volunteers' may be in short supply. Objectives To evaluate the implementation of buffy-coat-derived pooled platelet concentrates (PCs) for IQC material for LTA. Methods We used buffy-coat-derived pooled PCs from the blood bank as IQC material for LTA. On each weekend one PC was prepared (> 200 mL) and aliquoted from the original storage bag on a daily basis in four baby bags (40-50 mL), which were delivered from Monday to Friday to our laboratory. The IQC measurements of at least 85 work-weeks (from Monday to Friday) were evaluated with this new IQC material. LTA was performed on a four-channel Chronolog 700 Aggregometer (Chronolog Corporation, Havertown, PA, USA) (agonists: collagen, adenosine diphosphate [ADP], arachidonic acid [AA] and thrombin receptor activator peptide-6 [TRAP-6]). Results The medians of platelet aggregation from IQC measurements with collagen, ADP and AA from Monday to Friday were 68.0-59.5, 3.0-2.0 and 51.0-50.0%, respectively, and the mean of platelet aggregation with TRAP-6 was 71.2-66.4%. Conclusions Buffy-coat-derived pooled PCs serve as a reliable and robust IQC material for LTA measurements and would be beneficial for the whole laboratory procedure and employees' safety.

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Reduction in vasovagal reaction rate in young first‐time blood donors by collecting 350 mL rather than 450 mL

Abstract: With reduced collection volume, this study detected large and significant reduction in reaction rates among all females, as well as lower-weight males.

Cited by 9 publications

References 8 publications

Management of Young Blood Donors

Management of Young Blood Donors

Characterization of an Artificial Liver Support System-Related Vasovagal Reaction

Implementation of buffy‐coat‐derived pooled platelet concentrates for internal quality control of light transmission aggregometry: a proof of concept study

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