Zoon Vulvitis as a Differential Diagnosis in an HIV-Infected Patient

Reis, Helena Lúcia Barroso dos; Vargas, Paulo Roberto Merçon de; Lucas, Elton Almeida; Camporez, Thais; Ferreira, Dennis de Carvalho

doi:10.1177/2325957412467694

Cited by 6 publications

(20 citation statements)

References 4 publications

(14 reference statements)

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“… 2 , 3 Erosive lesions, which was the case of our patient, and granulomatous varieties are reported less frequently. 2 , 3 It can affect any part of the vulva with a bilateral and symmetrical distribution, with tendency to progressive confluence and to persist for many years. 2 Malignant changes have not been reported, 2 , 3 although lesions with moderate dysplasia have been described.…”

Section: Discussionmentioning

confidence: 46%

“…Zoon vulvitis is a rare, chronic and benign inflammation of the vulvar mucosa. 4 , 2 It affects women with ages between 26 and 70 years, rarely prepubertal girls. 2 , 3 It is an idiopathic condition, possibly due to a reaction of the vaginal mucosa to trauma and/ or infections.…”

Section: Discussionmentioning

confidence: 99%

“… 4 , 2 It affects women with ages between 26 and 70 years, rarely prepubertal girls. 2 , 3 It is an idiopathic condition, possibly due to a reaction of the vaginal mucosa to trauma and/ or infections. 2 It is characterized by well-defined, non-infiltrated, orange-yellow-colored plaques with cayenne pepper spots.…”

Section: Discussionmentioning

confidence: 99%

“… 2 , 3 It is an idiopathic condition, possibly due to a reaction of the vaginal mucosa to trauma and/ or infections. 2 It is characterized by well-defined, non-infiltrated, orange-yellow-colored plaques with cayenne pepper spots. 2 , 3 Erosive lesions, which was the case of our patient, and granulomatous varieties are reported less frequently.…”

Section: Discussionmentioning

confidence: 99%

“… 2 It is characterized by well-defined, non-infiltrated, orange-yellow-colored plaques with cayenne pepper spots. 2 , 3 Erosive lesions, which was the case of our patient, and granulomatous varieties are reported less frequently. 2 , 3 It can affect any part of the vulva with a bilateral and symmetrical distribution, with tendency to progressive confluence and to persist for many years.…”

Section: Discussionmentioning

confidence: 99%

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Zoon vulvitis

Damiani¹,

Quadros²,

Posser³

et al. 2017

An. Bras. Dermatol.

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Zoon vulvitis or vulvitis chronica plasmacellularis is a rare, chronic benign inflammation of the vulvar mucosa, diagnosed histologically, with variable therapeutic responses. It is important to be diagnosed because it mimics the presentation of other genital conditions, such as lichen planus and squamous cell carcinoma, which require specific treatment. We report a case of a female patient with three asymptomatic shallow ulcers on the labia minora. Laboratory tests ruled out infectious diseases and the biopsy was consistent with Zoon Vulvitis.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Zoon vulvitis

Damiani¹,

Quadros²,

Posser³

et al. 2017

An. Bras. Dermatol.

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Inflammatory Dermatoses Affecting the Dermis or Both the Epidermis and Dermis of the Vulva

Fernández‐Figueras

2014

Vulvar Pathology

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Plasma cell vulvitis: A systematic review

Sattler

Elsensohn

Mauskar

et al. 2021

International Journal of Women's Dermatology

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Background Plasma cell vulvitis (PCV) is an inflammatory vulvar dermatosis that is not well characterized. Diagnosis is often delayed, and the condition can be refractory to treatment. To date, there are no systematic reviews on this topic. Objective This study aimed to provide a systematic review of PCV, including epidemiologic, clinical, and histopathologic findings, as well as associated comorbidities and treatment options. Methods A primary literature search was conducted using the PubMed, Ovid Medline, Cochrane, and CINAHL databases. Results Fifty-three publications with 196 patients (mean age: 55.3 ± 14.5 years) were included. The majority of studies were case reports and case series. Common symptoms included burning/stinging (52%), dyspareunia (44%), and pruritus (41%). Common findings included erythema (84%), glistening/shiny appearance (29%), well-demarcated lesions (25%), and erosions (22%). Common anatomic sites were the labia minora (45%), introitus (31%), and periurethral (19%). Fifty-three percent of patients had a solitary lesion. Common histologic findings were a predominant plasma cell infiltrate (88%), presence of other inflammatory cells (55%), hemosiderin/siderophages (46%), and epidermal atrophy (43%). Topical corticosteroids (64%) and tacrolimus ointment (13%) were the most frequent treatment modalities. In most reports, previous treatments were tried, and there was a diagnostic delay. Conclusion PCV is likely underrecognized and should be considered in patients with erythema of the mucous and modified mucous membranes, symptoms of burning or stinging, and a predominant plasma cell infiltrate on histopathology. First-line therapy should begin with high-potency topical corticosteroids, with the most evidence for clobetasol 0.05% or tacrolimus 0.1% ointment. Prospective studies are needed to further characterize this condition and to develop treatment guidelines.

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Zoon Vulvitis as a Differential Diagnosis in an HIV-Infected Patient

Cited by 6 publications

References 4 publications

Zoon vulvitis

Zoon vulvitis

Inflammatory Dermatoses Affecting the Dermis or Both the Epidermis and Dermis of the Vulva

Plasma cell vulvitis: A systematic review

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