Circulating microRNAs levels in Chinese heart failure patients caused by dilated cardiomyopathy

Fan, Kang-Hsien; Zhang, Haifeng; Shen, Jie; Zhang, Qi; Li, Xinli

doi:10.1016/j.ihj.2012.12.022

Cited by 75 publications

(66 citation statements)

References 17 publications

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“…However, miR-155 was found to be decreased and associated with sex, age, and diabetes in patients with stable coronary artery disease [9]. In contrast to these studies, Fan et al [16] did not demonstrate any dysregulation in the plasma level of miR-155 in patients with dilated cardiomyopathy. In our study, miR-155 was found to be decreased in systolic HF patients.…”

Section: Resultsmentioning

confidence: 87%

The relationship between circulating microRNAs and left ventricular mass in symptomatic heart failure patients with systolic dysfunction

et al. 2015

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A b s t r a c tBackground: In recent years, many microRNAs (miRNAs) were shown to be dysregulated in specific tissues playing critical roles in the pathogenesis and progression of heart failure (HF). Left ventricular (LV) mass (LVM) has long been recognised as an important prognostic marker in systolic HF patients. Aim:We hypothesised that circulating miRNAs may be associated with LVM in systolic HF patients. The present study aimed to evaluate the relationship between previously reported and novel dysregulated circulating miRNAs and echocardiographically determined LVM in symptomatic HF patients with LV systolic dysfunction.Methods: Forty-two consecutive patients diagnosed with NYHA II-IV symptomatic systolic HF and a control group consisting of 15 age-and sex-matched healthy volunteers were enrolled. After labelling extracted RNA, poly-A tails were added. RNAs were later hybridised on a GeneChip miRNA 2.0 array. After hybridisation and staining, arrays were scanned to determine miRNA expression levels, and differentially expressed miRNAs were identified.Results: Eighteen miRNAs were found to be upregulated in serum of HF patients, while 11 were demonstrated to be downregulated. When the association between dysregulated miRNAs and echocardiographic findings was investigated, miR-182 (p = 0.04), miR-200a* (p = 0.019), and miR-568 (p = 0.023) were found to be inversely correlated with LVM index (LVMI), while miR-155 (p = 0.019) and miR-595 (p = 0.04) were determined to be positively correlated with LVMI. Conclusions:The results of our study revealed that dysregulated circulating miRNAs were correlated with anatomic changes in LV, in terms of LVMI, in symptomatic HF patients with systolic LV dysfunction.

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Section: Resultsmentioning

confidence: 87%

The relationship between circulating microRNAs and left ventricular mass in symptomatic heart failure patients with systolic dysfunction

et al. 2015

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“…Again, miR-423-5p was higher in dilated cardiomyopathy and was associated with B-type natriuretic peptide (r=0.43; P=0.003) and had a modestly strong discrimination for HF diagnosis (C-statistic, 0.67). 103 The association with natriuretic peptides and functional status in HF has been replicated for several other miRNAs in the literature. 104 For example, miR210 in peripheral mononuclear cells was noted to be higher in patients with more destabilized HF (by New York Heart Association functional class) in a study.…”

Section: Circulating Micrornas As Biomarkers In Human Hf: An Evolvingmentioning

confidence: 75%

MicroRNAs in Heart Failure

Melman

Shah²,

Das³

2014

Circ: Heart Failure

100

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“…Upon that, we demonstrated that plasma miR-3135b, miR-3908 and miR-5571-5p might be candidate biomarkers for DCM for the first time. Fan et al [20] identified miR-423-5p as a biomarker for HF caused by DCM. However, we did not find miR-423-5p levels in DCM to differ from those in the controls.…”

Section: Discussionmentioning

confidence: 99%