Diet across the Lifespan and the Association with Breast Density in Adulthood

Lindgren, Jessica A.; Dorgan, Joanne F.; Savage-Williams, Jennifer; Coffman, Donna L.; Hartman, Terryl J.

doi:10.1155/2013/808317

Cited by 19 publications

(7 citation statements)

References 64 publications

(135 reference statements)

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“…High mammographic density is a risk factor for breast cancer at all ages . Breast density in premenopausal women is affected by dietary intake of alcohol, vitamin D, and calcium, by IL‐6 levels, and by dehydroepiandrosterone sulfate (DHEAS) levels in early adolescence . Low vitamin D intake is associated with increased risk for premenopausal breast cancer and with the development of larger, higher grade tumors …”

Section: Risk Factorsmentioning

confidence: 99%

Breast cancer in adolescents and young adults

Johnson

Anders

Litton

et al. 2018

Pediatric Blood & Cancer

154

117

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Breast cancer is the most common cancer of adolescents and young adult (AYA) women aged 15 to 39 years, accounting for 5.6% of all invasive breast cancer in women. In comparison with older women, AYAs are more likely to have familial cancer predisposition genes, larger breast tumors, unfavorable biological characteristics, distant metastatic disease at diagnosis, and adverse outcome. Endocrine therapy and some chemotherapy recommendations differ between young and older women. AYAs require coordinated multidisciplinary care, treatment regimens that minimize late effects such as premature menopause and osteoporosis, and proactive management of psychological and sexual health during and after cancer treatment.

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Section: Risk Factorsmentioning

confidence: 99%

Breast cancer in adolescents and young adults

Johnson

Anders

Litton

et al. 2018

Pediatric Blood & Cancer

154

117

View full text Add to dashboard Cite

show abstract

“…High mammographic density is one of the strongest predictors of breast cancer risk [10–12] but little research has focused on early life dietary factors in relation to mammographic density [13], which may be an intermediate marker for breast cancer risk. Only three small studies (sample sizes from 91 to 451) have evaluated adolescent dietary fat and red meat intake in relation to premenopausal mammographic density; no associations were found [14–16].…”

Section: Introductionmentioning

confidence: 99%

Adolescent intake of animal fat and red meat in relation to premenopausal mammographic density

Bertrand

Burian

Eliassen

et al. 2016

Breast Cancer Res Treat

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Purpose Adolescence is hypothesized to be a time period of particular susceptibility to breast cancer risk factors. Red meat and fat intake during high school was positively associated with risk of breast cancer among premenopausal women in the Nurses’ Health Study II (NHSII). High mammographic density is a strong predictor of breast cancer risk but there is limited research on dietary factors associated with breast density. To test the hypothesis that high intake of animal fat or red meat during adolescence is associated with mammographic density, we analyzed data from premenopausal women in the NHSII. Methods Participants recalled adolescent diet on a high school food frequency questionnaire. We assessed absolute and percent mammographic density on digitized analog film mammograms for 687 premenopausal women with no history of cancer. We used generalized linear regression to quantify associations of adolescent animal fat and red meat intake with mammographic density, adjusting for age, body mass index, and other predictors of mammographic density. Results Adolescent animal fat intake was significantly positively associated with premenopausal mammographic density, with a mean percent density of 39.2% in the lowest quartile of adolescent animal fat intake vs. 43.1% in the highest quartile (p-trend: 0.03). A non-significant positive association was also observed for adolescent red meat intake (p-trend: 0.14). Conclusions These findings suggest that higher adolescent animal fat intake is weakly associated with percent mammographic density in premenopausal women.

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“…High ED diets are frequently high in fat, which has been positively associated with BD in some 10, 22–25 but not all studies 26, 27 . High ED diets also tend to be lower in fiber, which also could influence breast density 23, 24 .…”

Section: Introductionmentioning

confidence: 99%

Dietary Energy Density Is Positively Associated with Breast Density among Young Women

Jones¹,

Hartman²,

Klifa³

et al. 2015

Journal of the Academy of Nutrition and Dietetics

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Background Breast density is an established predictor of breast cancer risk, and there is considerable interest in associations of modifiable lifestyle factors, such as diet, with breast density. Objective To determine if dietary energy density (ED) is associated with percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) in young women. Design A cross-sectional analysis was conducted with women who participated in the Dietary Intervention Study in Children Follow-Up Study (DISC06). %DBV and ADBV were measured by magnetic resonance imaging (MRI). Diet was assessed by three 24-hour recalls. Dietary ED (kcal/g) was calculated using three methods: (1) food only, (2) food and caloric beverages, and (3) food and all beverages. Participants/setting 172 women (25–29 years) who were enrolled in the DISC06 study. Subjects who reported breast augmentation or reduction surgery or were pregnant or lactating within three months before breast density assessment were excluded. Main outcome measures ADBV and %DBV. Statistical analyses performed Multivariable linear mixed effects models were used. Final models were adjusted for race, smoking status, education, parity, duration of sex hormone use, whole body percent fat, childhood BMI z-score, and energy from beverages. Results After adjustment, each 1 kcal/g unit increase in food-only ED was associated with a 25.9% (95% confidence interval = 6.2 to 56.8%) increase in %DBV (p=0.01). Childhood BMI z-score modified the association between food-only ED and %DBV such that a significant positive association was observed only in women who were heavier as children. Food-only ED was not associated with ADBV in all women, but a borderline significant positive association was observed in women who had higher childhood BMI z-scores. Conclusions This is the first report to suggest a potential role for dietary ED in breast density; the effects of long-term exposure to high ED diets on breast cancer risk remain unknown.

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Diet across the Lifespan and the Association with Breast Density in Adulthood

Cited by 19 publications

References 64 publications

Breast cancer in adolescents and young adults

Breast cancer in adolescents and young adults

Adolescent intake of animal fat and red meat in relation to premenopausal mammographic density

Dietary Energy Density Is Positively Associated with Breast Density among Young Women

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