Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats

Aguiar, J. C. A.; Gomes, E. P. P.; Fonseca–Silva, Thiago; Velloso, N. A.; Vieira, Leonardo Tadeu; Fernandes, M; Santos, Sérgio Henrique Sousa; Neto, João Felício Rodrigues; De-Paula, A. M. B.; Guimarães, André Luiz Sena

doi:10.1111/jre.12049

Cited by 19 publications

(29 citation statements)

References 34 publications

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“…Branco‐de‐Almeida et al 22 observed that fluoxetine administration reduced periodontal disease severity in the rat model of ligature‐induced periodontitis. Similar results were obtained in the conditioned fear stress model in rats, in which fluoxetine treatment reduced periodontal bone loss 23 …”

supporting

confidence: 85%

“…Similar results were obtained in the conditioned fear stress model in rats, in which fluoxetine treatment reduced periodontal bone loss. 23 To the best of the author's knowledge, there is no study on the effect of fluoxetine on periodontitis in humans. Data from animal studies or in vitro models provide a rationale for exploring the potential benefit of fluoxetine in patients with periodontitis.…”

mentioning

confidence: 99%

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Effect of Fluoxetine on Periodontal Status in Patients With Depression: A Cross‐Sectional Observational Study

Bhatia

Sharma

Tewari

et al. 2015

Journal of Periodontology

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confidence: 85%

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confidence: 99%

Effect of Fluoxetine on Periodontal Status in Patients With Depression: A Cross‐Sectional Observational Study

Bhatia

Sharma

Tewari

et al. 2015

Journal of Periodontology

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“…The existing studies involve brain serotonin through selective serotonin reuptake inhibitor therapy (13,14,28), using varying doses to evaluate the anti-inflammatory effect of these drugs in periodontal disease. Two groups (13,14) found that treatment of periodontitis with 20 mg/kg/d fluoxetine reduced alveolar bone loss and disease progression. Further, Branco-de-Almeida et al (13) found that fluoxetine decrease cyclo-oxygenase-2 and interleukin-1b mRNA expression in the gingival tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Serotonin transporter polymorphisms for instance are associated with aggressive periodontitis (12). Furthermore, rat with induced periodontal disease treated with fluoxetine, a selective serotonin reuptake inhibitor, showed reduced alveolar bone loss (13,14) and inflammatory markers (13). While serotonin in the central nervous system seems to have a positive effect on periodontal disease, the role of gut serotonin, to the best of the authors 0 knowledge, has not been studied in a periodontitis model.…”

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confidence: 99%

The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease

Lima

Corazza

Moraes

et al. 2016

J of Periodontal Research

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Background and Objective LP533401 is an inhibitor of tryptophan hydroxylase 1, which regulates serotonin production in the gut. Previous work indicates that LP533401 has an anabolic effect in bone. Thus, we hypothesized that inhibition of gut serotonin production may modulate the host response in periodontal disease. In this study, we aimed to analyze the effects of LP533401 in a rat periodontitis model to evaluate the role of gut serotonin in periodontitis pathophysiology. Material and Methods Twenty-four rats were divided into three groups: treated group (T: ligature-induced periodontal disease and LP533401, 25 mg/kg/d) by gavage; ligature group (L: ligature-induced periodontal disease only); and control group (C: without ligature-induced periodontal disease). After 28 d, radiographic alveolar bone support was measured on digital radiographs, and alveolar bone volume fraction, tissue mineral density and trabeculae characteristics were quantified by microcomputed tomography in the right hemi-mandible. Left hemi-mandibles were decalcified and alveolar bone loss, attachment loss and area of collagen in the gingiva were histologically analyzed. Results Significant difference between the L and C groups was found, confirming that periodontal disease was induced. We observed no difference between the T and L groups regarding alveolar bone destruction and area of collagen. Conclusion LP533401 (25 mg/kg/d) for 28 d does not prevent bone loss and does not modulate host response in a rat model of induced periodontal disease.

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“…All of the selected experimental studies used adult rats (Wistar or Fischer 344) in the study design. Three different antidepressive drugs were used: tianeptine, venlafaxine, and fluoxetine . The main results of these studies are shown in Table .…”

Section: Resultsmentioning

confidence: 99%

Use of antidepressive agents as a possibility in the management of periodontal diseases: A systematic review of experimental studies

Muniz

Melo

Rösing

et al. 2017

J of Invest & Clin Dent

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Antidepressant agents have anti-inflammatory functions that could be interesting as adjuvants in periodontal therapy. The aim of the present study was to analyze the effect of antidepressive drugs in the management of periodontal disease. The MEDLINE, Scopus, Embase, LILACS, and SciELO databases were searched. To be included, the studies had to be experimental studies; randomized, controlled; double-blinded; or blinded studies. A total of 565 articles were initially searched, of which five were selected for the systematic review. All studies used rats, and three different drugs were evaluated: tianeptine, venlafaxine, and fluoxetine. Two of these studies evaluated the effect of antidepressive agents in rats submitted to both ligature-induced periodontitis and depression models, showing that depressive rats had greater alveolar bone loss (ABL). Only the venlafaxine study was not able to find any significant ABL reduction in the group that used this antidepressive drug. The other four studies showed statistically-significant differences, favoring the group with the antidepressant agent. Treatments that are able to modulate the brain-neuroendocrine-immune system could be used as an adjuvant to periodontal disease management. However, studies on humans and animals are scarce, limiting the conclusion of a positive effect in the present systematic review.

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Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats

Abstract: We showed that stress is associated with the progression of bone loss in a CFS model in rats and that fluoxetine treatment reduces the bone loss.

Cited by 19 publications

References 34 publications

Effect of Fluoxetine on Periodontal Status in Patients With Depression: A Cross‐Sectional Observational Study

Effect of Fluoxetine on Periodontal Status in Patients With Depression: A Cross‐Sectional Observational Study

The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease

Use of antidepressive agents as a possibility in the management of periodontal diseases: A systematic review of experimental studies

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