Sex differences in lipid peroxidation and fatty acid levels in recent onset schizophrenia

Ramos-Loyo, Julieta; Medina-Hernández, Virginia; Estarrón-Espinosa, Mirna; Canales-Aguirre, Alejandro A.; Gómez‐Pinedo, Ulises; Cerdán-Sánchez, Luis F.

doi:10.1016/j.pnpbp.2013.02.007

Cited by 24 publications

(14 citation statements)

References 92 publications

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“…Lipid peroxidation metabolites/TBARS including malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) have been measured in several studies. Consistent findings of increased RBC, plasma and serum levels of lipid peroxidation metabolites have been reported (Arvindakshan et al, 2003;Khan et al, 2002;Kuloglu et al, 2002;Ramos-Loyo et al, 2013;Ryazantseva et al, 2002).…”

Section: Lipid Peroxidation Metabolitessupporting

confidence: 67%

“…Another important variable to consider is the gender of the participants. Clear differences between male and female participants have been observed in some of the studies reviewed (Bicikova et al, 2013;Ramos-Loyo et al, 2013;Tsang et al, 2006) however several studies did not account for differences between sexes. Additionally, potentially important confounding variables such as diet, lifestyle, smoking status and stage of disease have not been measured or considered in the analyses.…”

Section: Biomarker Studies Challenges and Limitationsmentioning

confidence: 99%

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A systematic review of metabolite biomarkers of schizophrenia

Davison

O’Gorman

Brennan

et al. 2018

Schizophrenia Research

124

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Current diagnosis of schizophrenia relies exclusively on the potentially subjective interpretation of clinical symptoms and social functioning as more objective biological measurement and medical diagnostic tests are not presently available. The use of metabolomics in the discovery of disease biomarkers has grown in recent years. Metabolomic methods could aid in the discovery of diagnostic biomarkers of schizophrenia. This systematic review focuses on biofluid metabolites associated with schizophrenia. A systematic search of Web of Science and Ovid Medline databases was conducted and 63 studies investigating metabolite biomarkers of schizophrenia were included. A review of these studies revealed several potential metabolite signatures of schizophrenia including reduced levels of essential polyunsaturated fatty acids (EPUFAs), vitamin E and creatinine; and elevated levels of lipid peroxidation metabolites and glutamate. Further research is needed to validate these biomarkers and would benefit from large cohort studies and more homogeneous and well-defined subject groups.

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Section: Lipid Peroxidation Metabolitessupporting

confidence: 67%

Section: Biomarker Studies Challenges and Limitationsmentioning

confidence: 99%

A systematic review of metabolite biomarkers of schizophrenia

Davison

O’Gorman

Brennan

et al. 2018

Schizophrenia Research

124

View full text Add to dashboard Cite

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“…[32][33][34] and untreated [35,36] patients with schizophrenia, suggesting that increased peripheral lipid peroxidation in patients is likely not entirely mediated by antipsychotic use. We observed no significant change in lipid peroxidation in serum following antipsychotic administration in rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum

Andreazza

Barakauskas

Fazeli

et al. 2015

Neuroscience Letters

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“…For example, although several studies show gender specific alterations in fatty acids and their oxidation products in psychiatric disorders (McNamara et al 2007;Ramos-Loyo et al 2013;Colangelo et al 2017), this factor is not often systematically studied. In addition, more specific results could be seen if fatty acids would be linked to pathophysiological dimensions instead of only disorders, e.g., using the Research Domain Criteria (RDoC) (Insel 2014).…”

Section: Future Researchmentioning

confidence: 99%

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Mocking

Assies

Ruhé

et al. 2018

J of Inher Metab Disea

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Continuous research into the pathophysiology of psychiatric disorders, such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and schizophrenia, suggests an important role for metabolism. This narrative review will provide an upto-date summary of how metabolism is thought to be involved in the pathophysiology of these psychiatric disorders. We will focus on (I) the important role of fatty acids in these metabolic alterations, (II) whether fatty acid alterations represent epiphenomena or risk factors, and (III) similarities and dissociations in fatty acid alterations between different psychiatric disorders. (Historical) epidemiological evidence links fatty acid intake to psychiatric disorder prevalence, corroborated by altered fatty acid concentrations measured in psychiatric patients. These fatty acid alterations are connected with other concomitant pathophysiological mechanisms, including biological stress (hypothalamic-pituitary-adrenal (HPA)-axis and oxidative stress), inflammation, and brain network structure and function. Metabolomics and lipidomics studies are underway to more deeply investigate this complex network of associated neurometabolic alterations. Supplementation of fatty acids as disease-modifying nutraceuticals has clinical potential, particularly add-on eicosapentaenoic acid (EPA) in depressed patients with markers of increased inflammation. However, by interpreting the observed fatty acid alterations as partly (mal)adaptive phenomena, we attempt to nuance translational expectations and provide new clinical applications for these novel neurometabolic insights, e.g., to predict treatment response or depression recurrence. In conclusion, placing fatty acids in context can contribute to further understanding and optimized treatment of psychiatric disorders, in order to diminish their overwhelming burden of disease.

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Sex differences in lipid peroxidation and fatty acid levels in recent onset schizophrenia

Cited by 24 publications

References 92 publications

A systematic review of metabolite biomarkers of schizophrenia

A systematic review of metabolite biomarkers of schizophrenia

Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

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