Correlation Between Total Atrial Conduction Time Estimated via Tissue Doppler Imaging (PA‐TDI Interval), Structural Atrial Remodeling and New‐Onset of Atrial Fibrillation After Cardiac Surgery

Abstract

PA-TDI interval is useful to identify patients at risk for POAF undergoing cardiac surgery and correlates with the degree of atrial fibrosis.

Association between left atrial low-voltage area, serum apoptosis, and fibrosis biomarkers and incidence of silent cerebral events after catheter ablation of atrial fibrillation

“…Previously, our working group showed significant correlation of Fas-Ligand, an apoptosis biomarker, to atrial histological remodeling in patients undergoing cardiac surgery [26].…”

Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling

“…This cohort covers a subset of the population of a previous trial that evaluated the prognostic value of TACT for the onset of POAF [24]. After approval by the local institutional ethics committee on human study of the Ruhr University of Bochum (Bochum, Germany) we prospectively enrolled 39 noncritically ill patients who underwent cardiac surgery (coronary artery bypass graft, CABG, and/or aortic valve replacement, AVR).…”

“…In addition to surgery-associated factors (like inflammation, oxidative stress and increased sympathetic drive), preexisting factors, including ion channel alterations, interstitial impairments, myocardial apoptosis and fibrosis, may provide pathophysiological substrates of POAF [19,23,24]. …”

Reverse atrial remodeling in patients who maintain sinus rhythm after electrical cardioversion: evidence derived from the measurement of total atrial conduction time assessed by PA-TDI interval

“…PA-TDI interval, an echocardiographic parameter that combines electrical and mechanical information in order to derive a total atrial conduction time, is an independent predictor of new-onset AF and recurrent AF after catheter ablation and eCV [4,7,11,[14][15][16][17]. Recently, we showed that the PA-TDI interval predicts early recurrent atrial fibrillation (within 7 days) after successful eCV and moreover reflects the extent of structural atrial remodeling in patients undergoing cardiac surgery [4,7].…”

“…Electrical cardioversion (eCV) has been proven to be an effective treatment option aimed at the acute restoration of sinus rhythm (SR) [2], but recurrence rates without the use of additional anti-arrhythmic drug (AAD) therapy in the first weeks is high [3,4]. AF is related to left atrial fibrosis, the hallmark of structural atrial remodeling [5][6][7][8][9]. Electrical and structural atrial remodeling has been found to be independently associated with a higher recurrence rate of AF after eCV or catheter ablation [4,[9][10][11][12][13].…”