Relationship between diversion colitis and quality of life in rectal cancer

Abstract

The severity of DC is related to diarrhea after an ileostomy reversal and may adversely affect QoL.

Development and external validation of a nomogram and online tool to predict bowel dysfunction following restorative rectal cancer resection: the POLARS score

“…This association has been reported previously 35. The pathophysiology is believed to relate to disuse colitis and a prolonged period without restoration of bowel continuity, which may lead to irreversible colon and rectal atrophy 36.…”

Cytology of the neovagina in transgender women and individuals with congenital or acquired absence of a natural vagina

“…In bowel neovaginas, inflammatory changes have been related to the deprivation of luminal short‐chain fatty acids after surgical diversion of the faecal stream, a mechanism well known in diversion colitis . Diversion colitis is commonly observed in the remaining distal colonic parts after a colostomy or ileostomy (with a prevalence ranging from 70% to 100%) but may also occur after sigmoid vaginoplasty . Because short‐chain fatty acids play a significant role in the regulation of cellular differentiation and proliferation, it is speculated that short‐chain fatty acid deprivation may lead to an alteration of the cellular environment in favour of the development of colorectal carcinoma …”

Relationship between the Severity of Diversion Colitis and the Composition of Colonic Bacteria: A Prospective Study

“…We previously examined the frequency of diversion colitis among Koreans, and we assessed quality of life after ileostomy repair 18. In that study, we found considerable variation in the severity of diversion colitis between patients, and we hypothesized that this variation might be related to differences in the cause of diversion colitis between patients.…”