Jaw-Opening Reflex and Corticobulbar Motor Excitability Changes During Quiet Sleep in Non-Human Primates

Yao, Dongyuan; Lavigne, Gilles; Lee, Jye-Chang; Adachi, Kazunori; Sessle, Barry J.

doi:10.5665/sleep.2388

Cited by 14 publications

(15 citation statements)

References 76 publications

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“…As described above, sleep studies in non‐human primate models, including those in Cynomolgus monkeys, commonly used restraint chair for sleep assessments (Almirall et al ., ; Bouyer et al ., ; Holcombe et al ., ; Philip et al ., ; Yao et al ., ). However, to overcome limitations associated with restraint, studies have more recently began to use telemetry methodologies to record EEG in freely‐moving unrestrained monkeys (Crofts et al ., ; Hsieh et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Sleep electroencephalographic characteristics of the Cynomolgus monkey measured by telemetry

Rachalski

Authier²,

Bassett³

et al. 2014

Journal of Sleep Research

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SUMMARYCynomolgus monkeys are widely used as models of diseases and in preclinical studies to assess the impact of new pharmacotherapies on brain function and behaviour. However, the time course of electroencephalographic delta activity during sleep, which represents the main marker of sleep intensity associated with recovery during sleep, has never been described in this non-human primate. In this study, telemetry implants were used to record one spontaneous 24-h sleep-wake cycle in four freely-moving Cynomolgus monkeys, and to quantify the time course of electroencephalographic activity during sleep using spectral analysis. Animals presented a diurnal activity pattern interrupted by short naps. During the dark period, most of the time was spent in sleep with non-rapid eye movement sleep/rapid eye movement sleep alternations and sleep consolidation profiles intermediate between rodents and humans. Deep non-rapid eye movement sleep showed a typical predominance at the beginning of the night with decreased propensity in the course of the night, which was accompanied by a progressive increase in rapid eye movement sleep duration. Spectral profiles showed characteristic changes between vigilance states as reported in other mammalian species. Importantly, delta activity also followed the expected time course of variation, showing a build-up with wakefulness duration and dissipation across the night. Thus, Cynomolgus monkeys present typical characteristics of sleep architecture and spectral structure as those observed in other mammalian species including humans, validating the use of telemetry in this non-human primate model for translational sleep studies.

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Section: Discussionmentioning

confidence: 97%

Sleep electroencephalographic characteristics of the Cynomolgus monkey measured by telemetry

Rachalski

Authier²,

Bassett³

et al. 2014

Journal of Sleep Research

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“…Rhythmic jaw muscle activities were induced during NREM sleep and W in the present study using a CT stimulation. However, only one previous study, showing RJMAs induced by repetitive electrical microstimulations to the CMA in non‐human primates, challenged the experiment during the sleep period, but failed to induce RJMAs during light NREM sleep (Yao et al., ). This discrepancy may be related to quantitative differences in the recruitment of the descending fibres projecting to the masticatory motor system.…”

Section: Discussionmentioning

confidence: 99%

“…An electrical microstimulation to CT may activate descending fibres from larger cortical areas and induce a combined pattern of RJMAs with the greater premotoneuronal recruitment of the masticatory motor system than a focal electrical microstimulation to the CMA. (Yao et al, 2013). This discrepancy may be related to quantitative differences in the recruitment of the descending fibres projecting to the masticatory motor system.…”

Section: Discussionmentioning

confidence: 99%

“…The location of the neurons that constitute CPG was previously suggested to be in the brainstem reticular formation in the pons and medulla (Lund & Kolta, ; Nakamura & Katakura, ). Masticatory CPG is unique because repetitive electrical microstimulations of the cerebral cortex and its descending fibres (i.e., corticobulbar tracts [CT]) may induce rhythmic jaw movements during anaesthetized (Chandler, Nielsen, & Goldberg, ; Hidaka et al., ; Komuro et al., ; Satoh, Ishizuka, & Murakami, ; Uchino et al., ) as well as non‐anaesthetized (Hatanaka, Tokuno, Nambu, Inoue, & Takada, ; Isogai et al., ; Kato et al., ; Yao, Lavigne, Lee, Adachi, & Sessle, ) conditions in experimental animals. Studies have shown that masticatory CPG may be activated during sleep in experimental animals (Kato et al., , ).…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that masticatory CPG may be activated during sleep in experimental animals (Kato et al., , ). However, few studies have challenged the idea that the jaw motor system may be used as an experimental model to investigate the excitability of CPG in the generation of rhythmic jaw movements during sleep in animals (Yao et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Experimentally induced rhythmic jaw muscle activities during non‐rapid eye movement sleep in freely moving guinea pigs

Yamada

Higashiyama

Toyoda

et al. 2019

Journal of Sleep Research

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Rhythmic jaw muscle activities frequently occur during non‐rapid eye movement sleep in patients with sleep bruxism. The present study aimed to investigate the response characteristics of the masticatory rhythm generation during non‐rapid eye movement sleep in animals. Eleven guinea pigs were surgically prepared for polygraphic recordings by electromyography, electrooculography, electroencephalography and electrocardiography with the implantation of a stimulating electrode. Repetitive electrical microstimulations at three intensities were applied to the corticobulbar tract under freely moving conditions. The rhythmic electro‐myographic responses of the digastric and masseter muscles were scored and analysed. Changes in cortical electro‐encephalographic power and heart rate in association with these stimulations were quantified. Microstimulations to the corticobulbar tract induced rhythmic jaw muscle activities in digastric muscles, occasionally with masseter activities during wakefulness and non‐rapid eye movement sleep. The response rate of rhythmic jaw muscle activities was significantly lower (p < 0.01) and the response latency was significantly longer (p < 0.01) during non‐rapid eye movement sleep than during wakefulness. At higher stimulus intensities, the response rate increased and response latency decreased. The mean burst intervals of the digastric and masseter muscles were similar regardless of vigilance states and stimulus intensities. Induced rhythmic jaw muscle activities during non‐rapid eye movement sleep were followed by a transient decrease in delta power and increases in beta power and heart rate. During non‐rapid eye movement sleep, the masticatory motor system is able to generate rhythmic outputs to the jaw muscles in response to facilitatory inputs although the responsiveness was decreased from wakefulness.

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Orofacial Pain and Sleep

Sessle¹,

Adachi²,

Yao³

et al. 2017

Contemporary Oral Medicine

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Jaw-Opening Reflex and Corticobulbar Motor Excitability Changes During Quiet Sleep in Non-Human Primates

Abstract: The results suggest that the excitability of reflex and corticobulbar-evoked activity in the jaw motor system is depressed during QS.

Cited by 14 publications

References 76 publications

Sleep electroencephalographic characteristics of the Cynomolgus monkey measured by telemetry

Sleep electroencephalographic characteristics of the Cynomolgus monkey measured by telemetry

Experimentally induced rhythmic jaw muscle activities during non‐rapid eye movement sleep in freely moving guinea pigs

Orofacial Pain and Sleep

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