Autoinflammatory bone disorders

Morbach, Henner; Hedrich, Christian M.; Beer, Meinrad; Girschick, Hermann

doi:10.1016/j.clim.2012.12.012

Cited by 89 publications

(104 citation statements)

References 98 publications

(143 reference statements)

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“…Classic CRMO (OMIM #259680) presents in childhood with multifocal, sterile, osteolytic bone lesions with or without associated fever, frequently linked with an inflammatory disorder of the skin or gut, most often palmoplantar pustulosis, psoriasis, or Crohn's disease. 8,9 Sometimes the term CNO is utilized because the disease may be unifocal. 9 SAPHO syndrome is a phenotypically similar disease with onset in older adolescents or adults.…”

Section: Introductionmentioning

confidence: 99%

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Autoinflammatory Diseases Predominantly Affecting Bone and Joints

Ferguson

Goldbach‐Mansky

2014

Stiehm's Immune Deficiencies

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Section: Introductionmentioning

confidence: 99%

“…8,9 Sometimes the term CNO is utilized because the disease may be unifocal. 9 SAPHO syndrome is a phenotypically similar disease with onset in older adolescents or adults. 10À14 It has been debated whether CRMO and SAPHO are distinct disorders, or the same disorder with variable clinical presentation based on age of onset.…”

Section: Introductionmentioning

confidence: 99%

Autoinflammatory Diseases Predominantly Affecting Bone and Joints

Ferguson

Goldbach‐Mansky

2014

Stiehm's Immune Deficiencies

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“…Computed tomography is quick to get and is a preferred modality for emergency evaluations [5]. The bone scan also includes radiation but helpful in the diagnosis of inflammation sites close to the open physis that may be hard to evaluate by other mean [6].…”

Section: Imagingmentioning

confidence: 99%

Painful Spinal Conditions in Young Children and Adolescents

Tyagi¹

2016

J Bone Reports

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“…Other organs, including the skin, eyes, gastrointestinal tract, and lungs, can also be affected by inflammation (9,11,12). Skin inflammation manifests as palmoplantar pustulosis, acne, psoriasis, and rarely as pyoderma gangrenosum (1,2). The most important differential diagnosis is bacterial osteomyelitis, although it is not usually multifocal (13).…”

Section: Introductionmentioning

confidence: 99%

Characteristics and outcomes of chronic non-bacterial osteitis in children

Wintrich¹,

Horneff²

2015

Eur J Rheumatol

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Objective: To determine patient characteristics, clinical presentation, pattern of involvement, treatment, and outcome of patients with chronic non-bacterial osteitis (CNO).Material and Methods: Consecutive cases of CNO were analyzed at a single center for pediatrics and adolescent medicine from 2006 to 2013 in terms of patient characteristics, clinical presentation, pattern of involvement, treatment, and outcome. Results:We identified 32 children aged 1.5-15 years who were diagnosed with CNO between 2006 and 2013. A maximum of 12 bones per patient were affected in a total of 114 documented locations. The pelvis and clavicle (affecting 34% of patients each) were the most frequently affected bones. The foot skeleton was the most commonly affected region in 60% of patients. Skin manifestations were found in 7 (21%) patient. Increased inflammatory signs at presentation were detected in 18 patients. Pathological findings were found in all 30 children examined using magnetic resonance imaging (MRI), in 10 of 11 children examined using radiography, and in 8 of 10 patients examined using skeletal scintigraphy. Bone biopsy was performed in 9 patients. For initial treatment, non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs were used in 28 (87.5%) patients. Remission or satisfactory follow-up was achieved in all patients.Conclusion: Today, CNO is increasingly diagnosed using MRI and rarely through histological examinations. Therapeutic strategies include NSAIDs, which are often highly effective. All patients in the present study showed good clinical outcomes. Keywords: Chronic recurrent multifocal osteomyelitis, bone diseases, chronic disease IntroductionChronic non-bacterial osteitis (CNO) is a benign noninfectious autoinflammatory disease of the bone tissue with an incomplete etiology (1, 2). The incidence of CNO is 0.4/100.000 children (3). It was first reported by Giedion et al. (4) in 1972. There are several synonyms for CNO, such as chronic recurrent multifocal osteomyelitis (CRMO); non-bacterial osteitis; or synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome, all describing the same disease entity (5, 6). CNO generally occurs in children and adolescents, with a peak age of onset of 7-12 years (7). Localized bone pain is the leading symptom, often with local swelling and warmth (8). Patients are usually in good general condition. CNO can appear as a mono-/oligo-focal disease, as well as in chronic recurrent polyfocal stages with a risk of late effects, such as vertebral fractures and severe hyperostotic bone lesions (9). CNO primarily affects the metaphyses of long bones, although lesions can occur in any part of the skeleton (10). Other organs, including the skin, eyes, gastrointestinal tract, and lungs, can also be affected by inflammation (9,11,12). Skin inflammation manifests as palmoplantar pustulosis, acne, psoriasis, and rarely as pyoderma gangrenosum (1, 2). The most important differential diagnosis is bacterial osteomyelitis, although it is not usually multifocal (13). Even...

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Autoinflammatory bone disorders

Cited by 89 publications

References 98 publications

Autoinflammatory Diseases Predominantly Affecting Bone and Joints

Autoinflammatory Diseases Predominantly Affecting Bone and Joints

Painful Spinal Conditions in Young Children and Adolescents

Characteristics and outcomes of chronic non-bacterial osteitis in children

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