Changes in exhaled breath condensate <scp>pH</scp> in healthy and asthmatic pregnant women

Eszes, Noémi; Bikov, András; Lázár, Zsófia; Bohács, Anikó; Müller, Veronika; Stenczer, Balázs; Rigó, János; Losonczy, György; Horváth, Ildikó; Tamási, Lilla

doi:10.1111/aogs.12094

Cited by 5 publications

(5 citation statements)

References 31 publications

(50 reference statements)

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“…Although some studies showed modification in global metabolism during pregnancy [ 37 ], few studies focused on the EBC of these subjects. Some authors highlighted a higher EBC pH in healthy pregnant women than that from healthy non-pregnant women [ 38 ]. These findings may have an impact on metabolic profile and need to be fully explored.…”

Section: Discussionmentioning

confidence: 99%

Specific Metabolome Profile of Exhaled Breath Condensate in Patients with Shock and Respiratory Failure: A Pilot Study

et al. 2016

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Background: Shock includes different pathophysiological mechanisms not fully understood and remains a challenge to manage. Exhaled breath condensate (EBC) may contain relevant biomarkers that could help us make an early diagnosis or better understand the metabolic perturbations resulting from this pathological situation. Objective: we aimed to establish the metabolomics signature of EBC from patients in shock with acute respiratory failure in a pilot study. Material and methods: We explored the metabolic signature of EBC in 12 patients with shock compared to 14 controls using LC-HRMS. We used a non-targeted approach, and we performed a multivariate analysis based on Orthogonal Partial Least Square-Discriminant Analysis (OPLS-DA) to differentiate between the two groups of patients. Results: We optimized the procedure of EBC collection and LC-HRMS detected more than 1000 ions in this fluid. The optimization of multivariate models led to an excellent model of differentiation for both groups (Q2 > 0.4) after inclusion of only 6 ions. Discussion and conclusion: We validated the procedure of EBC collection and we showed that the metabolome profile of EBC may be relevant in characterizing patients with shock. We performed well in distinguishing these patients from controls, and the identification of relevant compounds may be promising for ICC patients.

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Section: Discussionmentioning

confidence: 99%

Specific Metabolome Profile of Exhaled Breath Condensate in Patients with Shock and Respiratory Failure: A Pilot Study

et al. 2016

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“…Wood et al showed the influence of Mycoplasma pneumonia infection in asthmatic children on EBC pH [ 54 ], but their follow-up study did not confirm the primary thesis [ 55 ]. Pregnancy did not alter the acidity of airways in asthmatic women [ 56 ]. Active smoking, which is connected with worse asthma management, lowered pH in samples [ 57 , 58 ].…”

Section: Biomarkers In Exhaled Breath Condensate Of Asthmatic Patientsmentioning

confidence: 99%

Exhaled Breath Condensate—A Non-Invasive Approach for Diagnostic Methods in Asthma

Połomska

Bar

Sozańska

2021

JCM

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The pathophysiology of asthma has been intensively studied, but its underlying mechanisms such as airway inflammation, control of airway tone, and bronchial reactivity are still not completely explained. There is an urgent need to implement novel, non-invasive diagnostic tools that can help to investigate local airway inflammation and connect the molecular pathways with the broad spectrum of clinical manifestations of asthma. The new biomarkers of different asthma endotypes could be used to confirm diagnosis, predict asthma exacerbations, or evaluate treatment response. In this paper, we briefly describe the characteristics of exhaled breath condensate (EBC) that is considered to be an interesting source of biomarkers of lung disorders. We look at the composition of EBC, some aspects of the collection procedure, the proposed biomarkers for asthma, and its clinical implications. We also indicate the limitations of the method and potential strategies to standardize the procedure of EBC collection and analytical methods.

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“…albuterol/salbutamol usage; methacholine induction of airway obstruction; and hypoventilation and hyperventilation [10,16,18]. Although gender does not influence EBC pH, it is noteworthy that pregnant women have higher pH values than non-pregnant individuals [19]. In addition, obesity does not influence EBC pH unless it is connected with obstructive sleep apnea [20], [21].…”

Section: Physiological Ph Of Ebcmentioning

confidence: 99%

“…Consequently, it is very difficult to form strong comparisons of the pH values between the control groups in the various studies. or FVC in adult [19,27,29] or pediatric population [26,30,32]. The acidity of the sample is normalized when the patient's exacerbation period is properly treated [42].…”

Section: Physiological Ph Of Ebcmentioning

confidence: 99%

A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

Muża¹,

Konieczna²,

Bączek³

2018

Preprint

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Exhaled breath condensate (EBC) sample analysis is an entirely non-invasive novel sample collection method that is fast, easy to perform, and effort-appeared independent. EBC samples can be very useful in identifying the biomarkers of many diseases. This review provides an updated overview of EBC pH disturbances in different disorders as well as physiological levels among healthy individuals since 2012. Our meta-analysis addresses some of the key questions related to sample processing before pH measurement and discusses various methods of condensate standardization that can be employed prior to conducting a pH assay. Given the recent widespread interest in research into the use of EBC to identify biomarkers, it is necessary to establish a pathway leading from analytical methods for biomarker evaluation using EBC pH to clinical applications of this technology. This review fills a gap in the literature and attempts to connect theory to practical analytical approaches to analyzing EBC samples and making critical treatment-related decisions next to the patient's bed.

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Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women

Cited by 5 publications

References 31 publications

Specific Metabolome Profile of Exhaled Breath Condensate in Patients with Shock and Respiratory Failure: A Pilot Study

Specific Metabolome Profile of Exhaled Breath Condensate in Patients with Shock and Respiratory Failure: A Pilot Study

Exhaled Breath Condensate—A Non-Invasive Approach for Diagnostic Methods in Asthma

A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

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