The High Rate of de novo Graft Carcinomas in Renal Transplant Recipients

Abstract

Background: To investigate the incidence, the clinical characteristics and outcomes of renal graft carcinomas in the same renal transplant population. Methods: From April 1989 to April 2012, 1,037 consecutive renal transplantations were performed in our department. Data were collected prospectively in an extensively maintained database. For all recipients, monitoring consisted of clinical examination and an abdominopelvic CT scan or ultrasonography at least once a year. Results: After 1,037 renal transplantations, 48 men and 14 women (sex ratio 3:4) with a mean age of 54 years (25.1–78.9) were included for urological malignancies. Eight graft carcinomas were identified: 7 renal cell carcinomas (5 papillary carcinomas and 2 clear cell carcinomas of the renal graft) and 1 transitional cell carcinoma of the ureteral graft (incidence 0.78%). Nephron-sparing surgery was chosen for 5 patients with good outcomes. All graft renal cell carcinomas were classified as pT1a and the mean size of tumors was 28.4 mm (range 6–45). The 5-year specific survival rate was 100%. No recurrence was observed with a mean follow-up of 36.8 months (4.1–84.3). Conclusion: Thus confirming an increased risk of de novo graft cancer, close monitoring of renal transplant recipients should be discussed with at least an abdominopelvic ultrasonography and PSA measurement once a year. Renal cell graft carcinomas seemed to be mostly small and of papillary type and low grade.

Urinary tuberculosis is associated with the development of urothelial carcinoma but not renal cell carcinoma: a nationwide cohort study in Taiwan

“…According to previous reports, de novo carcinoma in the transplantation recipients may be 10 times greater than in the general population (Viart et al , 2013). BK polyomavirus reactivation resulting from the use of immunosuppressant agents after transplantation is not uncommon.…”

Nephron Sparing Surgery for De Novo Kidney Graft Tumor: Results From a Multicenter National Study

“…The review of literature remains poor about the treatment of kidney graft tumors using NSS. Indeed there are fewer than 30 case reports in the literature (5,10-15) with acceptable (6,15). Two percutaneous renal mass biopsies (10.2%) were discordant with the final pathological analysis of the tumor (benign on biopsies and RCC on definitive histology).…”

TCC in Transplant Ureter—When and When Not to Preserve the Transplant Kidney

“…All cases of native UT and bladder TCC were excluded. Nineteen articles and 33 renal/ureteric TCCtu cases were found since 1995 (Table ) .…”