Systematic review and meta-analysis of the effect of perioperative steroids on ischaemia–reperfusion injury and surgical stress response in patients undergoing liver resection

Abstract

Perioperative steroids have a favourable impact on postoperative outcomes after liver resection.

The impact of preoperative corticosteroids on the systemic inflammatory response and postoperative complications following surgery for gastrointestinal cancer: A systematic review and meta-analysis

“…The results of the present study with regard to postoperative IL-6 are consistent with recent meta-analyses of randomized controlled trials of preoperative corticosteroids in colorectal surgery, liver surgery and esophagectomy [21][22][23][24]41]. In addition, the present metaanalysis reports a significant reduction in IL-6 on postoperative days 2, 3 and 5 in those patients given preoperative corticosteroids.…”

Preoperative Methylprednisolone Enhances Recovery After Endovascular Aortic Repair

“…16,17,19 Although procedure-specific dose-response studies are still required, the positive effects have been shown in biliary and hepatic surgery and colorectal procedures 16,19,29 and also in cardiac surgery regarding postoperative infection, duration of postoperative mechanical ventilation, hyperthermia, and LOS. 30,31 Before general recommendations for perioperative glucocorticoid administration can be made, obviously conclusive safety studies must be available.…”

“…30,31 Before general recommendations for perioperative glucocorticoid administration can be made, obviously conclusive safety studies must be available. So far, there seem to be no safety issues [15][16][17][18][19][29][30][31] related to a single preoperative dose of glucocorticoid including specific studies on wound healing. 32,33 The consequences of preoperative high-dose glucocorticoids for glucose homeostasis need further evaluation, but so far the transitory increased hyperglycemic response has not been related to increased postoperative complications 34 supported by the findings in this study-taking into account the limited number of patients in the subgroup of diabetic patients.…”

Traumatische Gefäßverletzungen

“…Die ausgeschütteten Zytokine, Chemokine, Wachstumsfaktoren und Zelloberflächenantigene haben während der Gewebeschädigung eine kurze Halbwertszeit, können allerdings über eine Verstär-kung der Signalkaskade und Aktivierung anderer Immunzellen einen sich weiter verstärkenden Schaden hervorrufen, besonders wenn die initiale Noxe bestehen bleibt [20,21]. Experimentell konnte sich die Gabe von Kortikosteroiden positiv auf diese Effekte auswirken [22,23].…”