The impact of chemotherapy-induced side effects on medical care usage and cost in German hospital care — an observational analysis on non-small-cell lung cancer patients

Ihbe-Heffinger, Angela; Paessens, Bernadette; Berger, Karin; Shlaen, Margarita; Bernard, R; Schilling, Christoph von; Peschel, Christian

doi:10.1007/s00520-012-1711-5

Cited by 20 publications

(20 citation statements)

References 28 publications

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“…[29303132] Several other researches indicate frequent hospitalization due to chemotherapy adverse effects. [333435] On the contrary, in the current study, although a majority of the study participants faced severe side effects for a week or more, a few hospitalizations were reported by them. The low number of hospitalization in the present study could be explained by the findings that the majority of the patients were educated by the HCWs about the management of chemotherapy side effects, before starting the actual therapy.…”

Section: Discussioncontrasting

confidence: 64%

Quality of life and its determinants in adult cancer patients undergoing chemotherapy treatment in Pakistan

Chagani

Parpio

Gul

et al. 2017

Asia-Pacific Journal of Oncology Nursing

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Objective:Cancer is a leading cause of death worldwide. Likewise, in Pakistan, it is a major health problem, with an approximate increase each year. Cancer treatment, particularly chemotherapy, produces a detrimental effect on individuals’ well-being. Since the past few years, quality of life (QOL) is considered as the primary goal of cancer treatment in patients’ survival. This study aimed to assess the QOL and its determinants in adult cancer patients undergoing chemotherapy treatment.Methods:An analytical cross-sectional design was employed to achieve the study objectives, utilizing consecutive sampling technique. A total of 150 adult (>19 years) cancer patients were recruited from a Tertiary Care Hospital in Karachi, Pakistan. The data were collected using the Functional Assessment of Cancer Therapy-General, a QOL questionnaire. Multiple linear regression was run to determine the effect of predictor variables, with a mean QOL score.Results:The overall mean score of QOL as 57.37. The domains of physical and emotional well-being were mainly affected by the chemotherapy treatment. Variables such as no previous hospitalization and no significant changes in life events were positively associated with the QOL. On the other hand, being female, unemployed, chemotherapy side effects (>1 week), impaired socialization, and discrimination by family/relatives were negatively associated with the QOL.Conclusions:The study findings suggested an overall low QOL among adult cancer patients undergoing chemotherapy treatment. It is recognized as a stressful treatment, which adversely affects the QOL of cancer patients. Interventions should focus on both the physical and psychological issues and need to be addressed to improve the QOL of adult cancer patients.

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Section: Discussioncontrasting

confidence: 64%

Quality of life and its determinants in adult cancer patients undergoing chemotherapy treatment in Pakistan

Chagani

Parpio

Gul

et al. 2017

Asia-Pacific Journal of Oncology Nursing

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“…Preventing the side effects may reduce the clinical burdens and will have considerable economic implications 18 . In this regard, the safety effect of BGT was assessed through in vitro and in vivo experiments.…”

Section: Discussionmentioning

confidence: 99%

Beta sitosterol and Daucosterol (phytosterols identified in Grewia tiliaefolia) perturbs cell cycle and induces apoptotic cell death in A549 cells

Rajavel

Ramar

Archunan

et al. 2017

Sci Rep

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Lung cancer is the leading cause of cancer related deaths both in developed and developing countries. Since majority of the existing therapeutic methods harms both normal and malignant cells, a viable alternative is to switch into safe and beneficial traditional medicinal plants. Hence the present study was framed to identify selective anti-lung cancer agents from the medicinal plant Grewia tiliaefolia (GT). Cell viability experiments showed that benzene extract of GT (BGT) leaf effectively inhibited the growth of A549 cells, while being non-toxic to normal human lung L132 and PBMC cells. Ames and comet assays demonstrated that BGT is of non-mutagenic and non-genotoxic nature in untransformed cells. The hematological and histopathological profiles of the in vivo acute and sub-acute toxicity studies demonstrated that BGT is safe and tolerable. Importantly, western blot analysis and Annexin V-FITC staining confirmed that BGT promotes mitochondrial dependent apoptotic cell death in A549 cells by arresting cell cycle at G2/M phase. Bio-assay guided fractionation revealed the presence of phytosteols (β-sitosterol and daucosterol) which significantly inhibited the growth of A549 cells both alone and in combination. This study warrants that these phytosterols in alone or in combination can be considered as safe and potential drug candidates for lung cancer treatment.

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“…Due to unavailability and poor cost-effectiveness of cancer treatment strategies including surgery, chemotherapy, phototherapy, and radiotherapy, nowadays much attention has been paid to preventive strategies and the promising role of diet [9][10][11][12]. Furthermore, a plethora of adverse effects has been reported from chemotherapeutic drugs [13][14][15][16][17]. Several epidemiological studies indicated that high fish consumption is inversely correlated with incidence of certain types of cancer [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 97%

Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

Nabavi

Bilotto

Russo

et al. 2015

Cancer Metastasis Rev

139

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Over the past decades, extensive studies have addressed the therapeutic effects of omega-3 polyunsaturated fatty acids (omega-3 FAs) against different human diseases such as cardiovascular and neurodegenerative diseases, cancer, etc. A growing body of scientific research shows the pharmacokinetic information and safety of these natural occurring substances. Moreover, during recent years, a plethora of studies has demonstrated that omega-3 FAs possess therapeutic role against certain types of cancer. It is also known that omega-3 FAs can improve efficacy and tolerability of chemotherapy. Previous reports showed that suppression of nuclear factor-κB, activation of AMPK/SIRT1, modulation of cyclooxygenase (COX) activity, and up-regulation of novel anti-inflammatory lipid mediators such as protectins, maresins, and resolvins, are the main mechanisms of antineoplastic effect of omega-3 FAs. In this review, we have collected the available clinical data on the therapeutic role of omega-3 FAs against breast cancer, colorectal cancer, leukemia, gastric cancer, pancreatic cancer, esophageal cancer, prostate cancer, lung cancer, head and neck cancer, as well as cancer cachexia. We also discussed the chemistry, dietary source, and bioavailability of omega-3 FAs, and the potential molecular mechanisms of anticancer and adverse effects.

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The impact of chemotherapy-induced side effects on medical care usage and cost in German hospital care — an observational analysis on non-small-cell lung cancer patients

Cited by 20 publications

References 28 publications

Quality of life and its determinants in adult cancer patients undergoing chemotherapy treatment in Pakistan

Quality of life and its determinants in adult cancer patients undergoing chemotherapy treatment in Pakistan

Beta sitosterol and Daucosterol (phytosterols identified in Grewia tiliaefolia) perturbs cell cycle and induces apoptotic cell death in A549 cells

Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

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