Mimicking Native Extracellular Matrix with Phytic Acid‐Crosslinked Protein Nanofibers for Cardiac Tissue Engineering

Ravichandran, R.; Seitz, Vera; Venugopal, Jayarama Reddy; Sridhar, R.; Sundarrajan, Subramanian; Mukherjee, Shayanti; Wintermantel, E.; Ramakrishna, Seeram

doi:10.1002/mabi.201200391

Cited by 62 publications

(42 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These nanofibers, cross-linked with phytic acid, hold promise to be an effective therapeutic agent for myocardial regeneration. 75 Biomaterials made of poly(glycerol sebacate) (PGS) core polymer and gelatin shell polymers have good cell adhesion, proliferation, and cytocompatibility properties. 76 Ravichandran et al have observed that the transplantation of the cells -along with the short nanofibers of PGS into the infarcted myocardium -results in an enhanced retention of the cells and increased expression of cardiac proteins like troponin, actinin, and connexin 43, compared with the standard cell injection system.…”

Section: Myocardial Regenerationmentioning

confidence: 99%

Regenerative nanomedicine: current perspectives and future directions

Chaudhury¹,

Kumar²,

Kandasamy³

et al. 2014

IJN

View full text Add to dashboard Cite

Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined.

show abstract

Section: Myocardial Regenerationmentioning

confidence: 99%

Regenerative nanomedicine: current perspectives and future directions

Chaudhury¹,

Kumar²,

Kandasamy³

et al. 2014

IJN

View full text Add to dashboard Cite

show abstract

“…1b and 1c) 23,28 and has a cross-linking effect on protein nanofibers. 27 The knowledge about IP6 and its use in adhesive dentistry are limited. Recently, it was reported that IP6 has the potential to be an effective etchant, which demonstrated good dentine bonding and minimal cytotoxicity to pulpal-like cells, when compared with PA. 29 However, the mechanism behind the high bond strength of resin adhesive to IP6-etched dentine was not clearly understood.…”

Section: Introductionmentioning

confidence: 99%

Effect of phytic acid etchant on the structural stability of demineralized dentine and dentine bonding

Kong

Islam

Nassar

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

“…Scaffolds for corneal tissue engineering should support cell survival and promote cell differentiation toward the corneal phenotype, which can be achieved by electrospun scaffolds due their bio-mimicking nanofibrous structure and excellent biocompatibility [52,81]. …”

Section: Applications Of Electrospun Scaffolds For Corneal Tissue mentioning

confidence: 99%

Electrospun Scaffolds for Corneal Tissue Engineering: A Review

Kong

2016

Materials

View full text Add to dashboard Cite

Corneal diseases constitute the second leading cause of vision loss and affect more than 10 million people globally. As there is a severe shortage of fresh donated corneas and an unknown risk of immune rejection with traditional heterografts, it is very important and urgent to construct a corneal equivalent to replace pathologic corneal tissue. Corneal tissue engineering has emerged as a practical strategy to develop corneal tissue substitutes, and the design of a scaffold with mechanical properties and transparency similar to that of natural cornea is paramount for the regeneration of corneal tissues. Nanofibrous scaffolds produced by electrospinning have high surface area–to-volume ratios and porosity that simulate the structure of protein fibers in native extra cellular matrix (ECM). The versatilities of electrospinning of polymer components, fiber structures, and functionalization have made the fabrication of nanofibrous scaffolds with suitable mechanical strength, transparency and biological properties for corneal tissue engineering feasible. In this paper, we review the recent developments of electrospun scaffolds for engineering corneal tissues, mainly including electrospun materials (single and blended polymers), fiber structures (isotropic or anisotropic), functionalization (improved mechanical properties and transparency), applications (corneal cell survival, maintenance of phenotype and formation of corneal tissue) and future development perspectives.

show abstract

Mimicking Native Extracellular Matrix with Phytic Acid‐Crosslinked Protein Nanofibers for Cardiac Tissue Engineering

Cited by 62 publications

References 21 publications

Regenerative nanomedicine: current perspectives and future directions

Regenerative nanomedicine: current perspectives and future directions

Effect of phytic acid etchant on the structural stability of demineralized dentine and dentine bonding

Electrospun Scaffolds for Corneal Tissue Engineering: A Review

Contact Info

Product

Resources

About