Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population-based longitudinal follow-up study

Abstract

These findings suggest that DMS is associated with an increased risk of cardiovascular and cerebrovascular events.

Autoimmune Myopathies: Updates on Evaluation and Treatment

“…DM is also associated with multiple systemic complications, including cardiac, pulmonary, gastrointestinal, and rheumatological involvement, as well as systemic malignancies (in adult-onset DM). Potential cardiac complications include conduction system abnormalities and arrhythmias, pericarditis, myocarditis, coronary artery disease, and congestive heart failure/diastolic dysfunction [16][17][18][19][20]. Interstitial lung disease (ILD) can occur in 15 to 20% of DM patients, typically presenting with a dry cough, shortness of breath, fine inspiratory bibasal crackles on lung examination, and a restrictive pattern on pulmonary function testing [21,22].…”

Risk of deep venous thrombosis and pulmonary embolism in individuals with polymyositis and dermatomyositis: a general population-based study

“…While an increased risk of cardiovascular disease (CVD) has been shown in other autoimmune rheumatic diseases, including rheumatoid arthritis (RA),7–9 scleroderma,10 ankylosing spondylitis11 and systemic lupus erythematosus (SLE),12 13 data on CVD in patients with inflammatory myopathies are scarce and have focused almost entirely on atherosclerotic disease 14 15…”

Is it cardiac involvement mimicking acute myocardial infarction in idiopathic inflammatory myopathy?

“…In 2009, Tisseverasinghe et al (15) reported a high incidence of arterial events in IIM patients. A longitudinal follow-up study by Lai et al (16) demonstrated that DM is associated with an increased risk of cardiovascular events, particularly AMI. Other studies confirmed this finding (17)(18)(19); however, the specific risk factors of AMI in IIM patients have remained to be investigated.…”

“…Flow-mediated dilatation of the brachial artery, arterial stiffness and carotid artery thickness on ultrasonography may be predictors of cardiovascular disease in IIM patients (18). Case 4, who suffered a left hemispheric infarction 9 years after AMI, indicated that not only cardiovascular but also cerebrovascular disease poses a high risk (12,16).…”

“…Administration of glucocorticoids at high doses or for a long time is a risk factor for diabetes mellitus, hypertension and hyperlipidemia, resulting in atherosclerosis or cardiovascular disease, particularly coronary heart disease (20). This may in part explain for the high infarction risk in IIM patients (16)(17)(18)(19). Glucocorticoid dosages should be gradually reduced when the disease can be controlled.…”