1628KAWAJI T et al.
Circulation JournalOfficial Journal of the Japanese Circulation Society http://www. j-circ.or.jphas not been thoroughly evaluated yet. To address this issue, the current single center study sought to evaluate the long-term efficacy and safety outcomes, including the incidence of major bleeding, after unrestricted use of DES in the setting of emergency PCI for ACS patients.
Methods
Study PopulationBetween September 2004 and December 2011, 613 patients were admitted to Kyoto University Hospital with a clinical diagnosis of ACS and underwent emergency PCI. ACS was defined as ST-segment elevation acute myocardial infarction ecent randomized clinical trials comparing secondgeneration drug-eluting stents (DES) with bare-metal stents (BMS) in patients with acute myocardial infarction (MI) have reported comparable safety outcomes, as well as with a significant reduction of target-lesion revascularization (TLR) in DES patients. 1,2 Reflecting these study results, DES use in the setting of acute coronary syndrome (ACS) has become more common in daily clinical practice. For ACS patients receiving DES, the current guidelines recommend prolonged duration of dual antiplatelet therapy (DAPT), although adequate assessment of bleeding risk might be difficult in the setting of emergency PCI. 3 However, the long-term bleeding outcome after DES implantation in real-world ACS patients Background: Recent randomized clinical trials have reported favorable clinical outcomes after the use of drugeluting stents (DES) in patients with acute coronary syndrome (ACS). However, the long-term efficacy and safety outcomes, bleeding outcome in particular, after DES implantation in ACS patients have not been thoroughly evaluated in a real-world population.