Elevated Serum Endostatin Levels are Associated with Poor Survival in Patients with Advanced-stage Nasopharyngeal Carcinoma

Mo, Hao Yuan; Luo, Dong Hua; Qiu, Hui; Liu, Huai; Chen, Qiu Yan; Tang, Lin; Zhong, Zong Liang; Huang, Pei Yu; Zhao, Zheng; Zhang, Chang Qing; Zhang, Ying; Qiang, Hai

doi:10.1016/j.clon.2012.11.009

Cited by 11 publications

(9 citation statements)

References 38 publications

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“…Elevated circulating endostatin concentration in patients with malignancies compared with healthy controls has been corroborated by a growing body of evidence (11)(12)(13), which was consistent with our findings. By contrast, circulating concentration was not enhanced in head and neck squamous cell carcinoma and hepatocellular carcinoma (14,27).…”

Section: Discussionsupporting

confidence: 82%

“…The findings of this study were in accordance with those of two studies on hepatocellular carcinoma and cervical cancer (12,15). By contrast, a higher endostatin level was found to correlate with poor prognosis in previous studies (11,13).…”

Section: Discussionmentioning

confidence: 72%

“…Additionally, no definite conclusion has been reached regarding the clinical value of endostatin expression in tumor patients. It was previously documented that tumor patients with poor survival have higher endostatin (11,13,14). By contrast, no association was found between the endostatin level and patient prognosis (12,15).…”

Section: Introductionmentioning

confidence: 93%

“…Elevated circulating endostatin level has been observed in a variety of malignancies (11)(12)(13). Additionally, no definite conclusion has been reached regarding the clinical value of endostatin expression in tumor patients.…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of serum and tumor tissue endostatin evaluation in operable non-small cell lung cancer

Zhang

et al. 2014

Biomedical Reports

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Abstract. Endostatin, as the most potential antiangiogenic factor, is a naturally occurring fragment of collagen XVIII in bloodstream capable of inhibiting tumor growth and metastasis. This study was conducted to explore the clinical value of endostatin in serum and tumor tissue in patients with operable non-small cell lung cancer (NSCLC). ELISA and immunohistochemistry were applied to detect the expression of endostatin in serum and tumor tissue in 105 patient-matched operable NSCLC patients. The serum level of endostatin was significantly higher in NSCLC patients than healthy individuals (P=0.0018). Cases with poorer differentiation showed a higher endostatin serum level (P=0.008). There was no significant correlation between tumor tissue expression and clinical parameters, such as TNM stage, differentiation degree, histological type and lymph node invasion status. A stronger expression of endostain in tumor tissue was associated with a higher serum level (r=0.223). The univariate and multivariate analyses with Cox proportional hazards model for overall survival showed that tumor stage and node status were independent prognostic factors, whereas neither endostatin levels in serum nor in tumor tissue showed potential in predicting the long-term survival of operable NSCLC patients. In conclusion, the results observed in the present study did not support the prediction of overall survival in operable NSCLC based on the expression levels of endostatin in serum and tumor tissue.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Clinical significance of serum and tumor tissue endostatin evaluation in operable non-small cell lung cancer

Zhang

et al. 2014

Biomedical Reports

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“…These studies further illustrate the roles and balance of both positive and negative regulatory factors in tumor angiogenesis [5]. Studies have also indicated the potential of endostatin as a marker of prognostic value in hepatocellular carcinoma [197], bladder cancer [200], cervical cancer [204], colorectal cancer [208], nasopharyngeal carcinoma [211], bronchopulmonary dysplasia [219], pulmonary arterial hypertension [214], traumatic brain injury [217], intermittent claudication in peripheral vascular disease [270], benign vs. malignant ascites [271], Alzheimer’s disease [216], and chronic kidney disease [196]. …”

Section: Discussionmentioning

confidence: 92%

Endostatin's emerging roles in angiogenesis, lymphangiogenesis, disease, and clinical applications

Walia

Yang

Huang

et al. 2015

Biochimica et Biophysica Acta (BBA) - General Subjects

154

126

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Background Angiogenesis is the process of neovascularization from pre-existing vasculature and is involved in various physiological and pathological processes. Inhibitors of angiogenesis, administered either as individual drugs or in combination with other chemotherapy, have been shown to benefit patients with various cancers. Endostatin, a 20-kDa C-terminal fragment of type XVIII collagen, is one of the most potent inhibitors of angiogenesis. Scope of review We discuss the biology behind endostatin in the context of its endogenous production, the various receptors to which it binds, and the mechanisms by which it acts. We focus on its inhibitory role in angiogenesis, lymphangiogenesis, and cancer metastasis. We also present emerging clinical applications for endostatin and its potential as a therapeutic agent in the form a short peptide. Major conclusions The delicate balance between pro- and anti-angiogenic factors can be modulated to result in physiological wound healing or pathological tumor metastasis. Research in the last decade has emphasized an emerging clinical potential for endostatin as a biomarker and as a therapeutic short peptide. Moreover, elevated or depressed endostatin levels in diseased states may help explain the pathophysiological mechanisms of the particular disease. General significance Endostatin was once sought after as the ‘be all and end all’ for cancer treatment; however, research throughout the last decade has made it apparent that endostatin’s effects are complex and involve multiple mechanisms. A better understanding of newly discovered mechanisms and clinical applications still has the potential to lead to future advances in the use of endostatin in the clinic.

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Cancer as a Disease of Homeostasis: An Angiogenesis Perspective

Kareva

2017

Ecology and Evolution of Cancer

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Elevated Serum Endostatin Levels are Associated with Poor Survival in Patients with Advanced-stage Nasopharyngeal Carcinoma

Cited by 11 publications

References 38 publications

Clinical significance of serum and tumor tissue endostatin evaluation in operable non-small cell lung cancer

Clinical significance of serum and tumor tissue endostatin evaluation in operable non-small cell lung cancer

Endostatin's emerging roles in angiogenesis, lymphangiogenesis, disease, and clinical applications

Cancer as a Disease of Homeostasis: An Angiogenesis Perspective

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