Discovery of coumarin–monastrol hybrid as potential antibreast tumor-specific agent

Sashidhara, Koneni V.; Avula, Srinivasa Rao; Sharma, Komal; Palnati, Gopala Reddy; Bathula, Surendar Reddy

doi:10.1016/j.ejmech.2012.11.044

Cited by 87 publications

(28 citation statements)

References 17 publications

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“…Additionally, the coumarin-monastrol hybrid II demonstrated anticancer efficacy against many cancer cell lines mediated by apoptotic activity [33] (Figure 1). …”

Section: Graphical Abstractmentioning

confidence: 99%

Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells

Amin

Abou‐Seri

Awadallah

et al. 2015

European Journal of Medicinal Chemistry

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“…Additionally, the coumarin-monastrol hybrid II demonstrated anticancer efficacy against many cancer cell lines mediated by apoptotic activity [33] (Figure 1). …”

Section: Graphical Abstractmentioning

confidence: 99%

Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells

Amin

Abou‐Seri

Awadallah

et al. 2015

European Journal of Medicinal Chemistry

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“…The in vitro screening of compounds 73 against various cancer cell lines revealed that 8-tert-butyl-3-(3,4,5-trimethoxyphenyl)coumarin derivative (R= t-Bu, R'= 3,4,5-(MeO) 3 , X= S) was the most potent compound against MCF7, T47D, and MDAMB231 cells. The result of biological assays showed that the latter compound is cell specific and its selective toxicity is ER independent in both hormone positive and hormone negative breast cancer cells [127].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Current developments of coumarin-based anti-cancer agents in medicinal chemistry

Emami

Dadashpour

2015

European Journal of Medicinal Chemistry

416

185

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“…It was found that hybrid (23) was effective in breast cancer cells (MCF-7 and MDA-MB-231). It worked by inducing caspase-3 activation and followed by apoptosis in both cell lines [41].…”

Section: Caspase-3 Activationmentioning

confidence: 99%

A Review of Benzopyran Derivatives in Pharmacotherapy of Breast Cancer

Kumar

Singh

Azizur

et al. 2018

Asian J Pharm Clin Res

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One of the naturally occurring compounds containing oxygen moiety is benzopyran. Depending on its substitution pattern, different biological effects are shown. The benzopyran ring system is present in many natural products (such as genistein, hesperidin, and warfarin) as well as synthetic products. It displays pharmacological properties such as antitumor, anti-HIV, antimicrobials, anti-inflammatory, and anticoagulants. The sufficient literature support and the fact that benzopyran has potential as a pharmacophore particularly as anti-breast cancer, etc, current research seemed pertinent keeping in view the mechanism of anti-breast cancer activity. Therefore, the objective of this review is to focus on important benzopyran analogs with anti-breast cancer activity and highlight their mechanisms of action.

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Discovery of coumarin–monastrol hybrid as potential antibreast tumor-specific agent

Cited by 87 publications

References 17 publications

Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells

Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells

Current developments of coumarin-based anti-cancer agents in medicinal chemistry

A Review of Benzopyran Derivatives in Pharmacotherapy of Breast Cancer

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