Solitary pulmonary metastasis from lung cancer harboring EML4–ALK after a 15-year disease-free interval

Tomizawa, Kenji; Ito, Simon; Suda, Kenichi; Fukui, Takayuki; Usami, Noriyasu; Hatooka, Shunzo; Kuwano, Hiroyuki; Yatabe, Yasushi; Mitsudomi, Tetsuya

doi:10.1016/j.lungcan.2012.12.011

Cited by 8 publications

(1 citation statement)

References 10 publications

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“…However, there is a possibility of its recurrence even after a long interval. Studies have shown recurrence over 15 years after resection in cases with adenocarcinoma with ALK rearrangement 9,12–14. Therefore, a long follow-up period is recommended, particularly in patients with adenocarcinoma with ALK rearrangement.…”

Section: Discussionmentioning

confidence: 99%

<p>Ultra-late recurrence of non-small cell lung cancer over 10 years after curative resection</p>

Sonoda¹,

Matsuura²,

Ichinose³

et al. 2019

CMAR

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Purpose Most postoperative recurrences of non-small cell lung cancer (NSCLC) develop within 5 years after curative resection, with ultra-late recurrences developing over 10 years after the resection being rare. This study aimed to analyze the features of ultra-late recurrence in cases with NSCLC who had undergone curative resection. Patients and methods Among 1458 consecutive cases with NSCLC who underwent curative resection with systematic lymph node dissection during 1990–2006, 12 cases developed recurrence over 10 years after the resection. We defined the recurrence developing over 10 years after the resection as ultra-late recurrence and analyzed the factors related to it. Results Among the 1458 cases, recurrence developed in 476 (32.6%) cases. Of them, ultra-late recurrence developed in 12 (2.5%) cases. The ultra-late recurrence was histopathologically classified as adenocarcinoma in 11 cases and atypical carcinoid in 1 case. All cases were of invasive carcinoma. We compared ultra-late recurrence cases with non-recurrence cases and showed that none of the examined factors significantly influenced ultra-late recurrence; however, lymphatic invasion was close to significantly influencing it. There were two cases in which recurrence developed over 15 years after the resection; both cases were of adenocarcinoma with anaplastic lymphoma kinase (ALK) rearrangement. Conclusion There is a possibility of ultra-late recurrence developing over 10 years after the resection of any invasive NSCLC. Lymphatic invasion is close to significantly influencing ultra-late recurrence. Furthermore, a long follow-up period may be required in cases with adenocarcinoma with ALK rearrangement because it has the possibility of recurrence over 15 years after the resection.

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Section: Discussionmentioning

confidence: 99%