Gap junction -mediated cAMP movement between oocytes and somatic cells

Mao, Guan Kun; Li, Jun Xia; Bian, Feng; Han, Ying; Guo, Meng; Xu, Baoshan; Zhang, Mei Jia; Guo, Xia

doi:10.2741/e656

Cited by 14 publications

(8 citation statements)

References 65 publications

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“…Studies in mammalian systems have suggested that cyclic nucleotides can also pass through gap junctions to affect cellular function. For example, cAMP movement between cells has been visualized following ectopic expression of gap junction components in human tissue culture [ 29 , 74 , 75 ]. cAMP movement through gap junctions also suppresses CD4+ T-cell function [ 76 ] and may alter gene expression in myelinating Schwann cells [ 77 ].…”

Section: Resultsmentioning

confidence: 99%

“…cAMP movement through gap junctions also suppresses CD4+ T-cell function [ 76 ] and may alter gene expression in myelinating Schwann cells [ 77 ]. In addition, cGMP can pass through gap junctions in human cell culture, as well as between cultured mouse follicle cells and oocytes [ 29 , 30 , 32 , 78 ]. While 25 innexins are encoded by the C .…”

Section: Resultsmentioning

confidence: 99%

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Aversive Behavior in the Nematode C. elegans Is Modulated by cGMP and a Neuronal Gap Junction Network

et al. 2016

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All animals rely on their ability to sense and respond to their environment to survive. However, the suitability of a behavioral response is context-dependent, and must reflect both an animal’s life history and its present internal state. Based on the integration of these variables, an animal’s needs can be prioritized to optimize survival strategies. Nociceptive sensory systems detect harmful stimuli and allow for the initiation of protective behavioral responses. The polymodal ASH sensory neurons are the primary nociceptors in C. elegans. We show here that the guanylyl cyclase ODR-1 functions non-cell-autonomously to downregulate ASH-mediated aversive behaviors and that ectopic cGMP generation in ASH is sufficient to dampen ASH sensitivity. We define a gap junction neural network that regulates nociception and propose that decentralized regulation of ASH signaling can allow for rapid correlation between an animal’s internal state and its behavioral output, lending modulatory flexibility to this hard-wired nociceptive neural circuit.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Aversive Behavior in the Nematode C. elegans Is Modulated by cGMP and a Neuronal Gap Junction Network

et al. 2016

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“…The cumulus cells continue the important role of supporting the development of the growing oocyte and its eventual acquisition of competence to form an embryo with high developmental potential. Specifically, cumulus cells sense and respond to maternal endocrine and paracrine signals to produce energy, cyclic nucleotides (cAMP and cGMP), and RNA and transfer these to the oocyte via gap junctions ( 176 , 177 ). These factors regulate oocyte meiotic arrest/resumption through cell cycle-regulating complexes ( 178 – 180 ).…”

Section: Folliculogenesismentioning

confidence: 99%

Stem Cells, Progenitor Cells, and Lineage Decisions in the Ovary

et al. 2015

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Exploring stem cells in the mammalian ovary has unleashed a Pandora's box of new insights and questions. Recent evidence supports the existence of stem cells of a number of the different cell types within the ovary. The evidence for a stem cell model producing mural granulosa cells and cumulus cells is strong, despite a limited number of reports. The recent identification of a precursor granulosa cell, the gonadal ridge epithelial-like cell, is exciting and novel. The identification of female germline (oogonial) stem cells is still very new and is currently limited to just a few species. Their origins and physiological roles, if any, are unknown, and their potential to produce oocytes and contribute to follicle formation in vivo lacks robust evidence. The precursor of thecal cells remains elusive, and more compelling data are needed. Similarly, claims of very small embryonic-like cells are also preliminary. Surface epithelial cells originating from gonadal ridge epithelial-like cells and from the mesonephric epithelium at the hilum of the ovary have also been proposed. Another important issue is the role of the stroma in guiding the formation of the ovary, ovigerous cords, follicles, and surface epithelium. Immune cells may also play key roles in developmental patterning, given their critical roles in corpora lutea formation and regression. Thus, while the cellular biology of the ovary is extremely important for its major endocrine and fertility roles, there is much still to be discovered. This review draws together the current evidence and perspectives on this topic.

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“…It has been well-known that COCs not only secrete paracrine factors but they also interact through the gap junctions (passing molecules only smaller than 1 kDa, [8]) in a bidirectional manner, which is essential for oocyte nutrition, growth, and regulation of meiotic progression [9][10][11]. Also, CCs contribute partially to maintain the oocyte into meiotic arrest by the production and transfer of cAMP via gap junctions, which accumulates into the ooplasm [12]. The communication through the gap junctions between the oocyte and CCs decreases progressively during IVM [13,14].…”

Section: Introductionmentioning

confidence: 99%